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1.
Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT).
Bioorg Med Chem Lett
; 74: 128928, 2022 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35961460
2.
Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors.
Bioorg Med Chem Lett
; 74: 128929, 2022 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-35961461
3.
Switch control pocket inhibitors of p38-MAP kinase. Durable type II inhibitors that do not require binding into the canonical ATP hinge region.
Bioorg Med Chem Lett
; 20(19): 5793-8, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20800479
4.
Ripretinib (DCC-2618) Is a Switch Control Kinase Inhibitor of a Broad Spectrum of Oncogenic and Drug-Resistant KIT and PDGFRA Variants.
Cancer Cell
; 35(5): 738-751.e9, 2019 05 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-31085175
5.
The Selective Tie2 Inhibitor Rebastinib Blocks Recruitment and Function of Tie2Hi Macrophages in Breast Cancer and Pancreatic Neuroendocrine Tumors.
Mol Cancer Ther
; 16(11): 2486-2501, 2017 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28838996
6.
Altiratinib Inhibits Tumor Growth, Invasion, Angiogenesis, and Microenvironment-Mediated Drug Resistance via Balanced Inhibition of MET, TIE2, and VEGFR2.
Mol Cancer Ther
; 14(9): 2023-34, 2015 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-26285778
7.
Discovery of 1-(3,3-dimethylbutyl)-3-(2-fluoro-4-methyl-5-(7-methyl-2-(methylamino)pyrido[2,3-d]pyrimidin-6-yl)phenyl)urea (LY3009120) as a pan-RAF inhibitor with minimal paradoxical activation and activity against BRAF or RAS mutant tumor cells.
J Med Chem
; 58(10): 4165-79, 2015 May 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-25965804
8.
Conformational control inhibition of the BCR-ABL1 tyrosine kinase, including the gatekeeper T315I mutant, by the switch-control inhibitor DCC-2036.
Cancer Cell
; 19(4): 556-68, 2011 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-21481795
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