Detalles de la búsqueda
1.
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.
Nature
; 622(7984): 850-862, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-37794185
2.
Implications of the Conformationally Flexible, Macrocyclic Structure of the First-Generation, Direct-Acting Anti-Viral Paritaprevir on Its Solid Form Complexity and Chameleonic Behavior.
J Am Chem Soc
; 143(42): 17479-17491, 2021 10 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-34637297
3.
Novel, potent, selective and brain penetrant vasopressin 1b receptor antagonists.
Bioorg Med Chem Lett
; 28(19): 3260-3264, 2018 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30098866
4.
Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.
Bioorg Med Chem Lett
; 28(10): 1804-1810, 2018 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29678460
5.
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds.
J Med Chem
; 67(8): 6456-6494, 2024 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38574366
6.
CRISPR Screen Reveals BRD2/4 Molecular Glue-like Degrader via Recruitment of DCAF16.
ACS Chem Biol
; 18(2): 331-339, 2023 02 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36656921
7.
Discovery of a Potent Chloroacetamide GPX4 Inhibitor with Bioavailability to Enable Target Engagement in Mice, a Potential Tool Compound for Inducing Ferroptosis In Vivo.
J Med Chem
; 66(6): 3852-3865, 2023 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36877935
8.
Molecular determinants of species-specific activation or blockade of TRPA1 channels.
J Neurosci
; 28(19): 5063-71, 2008 May 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-18463259
9.
Preparation and characterization of N-(3-pyridinyl) spirocyclic diamines as ligands for nicotinic acetylcholine receptors.
Bioorg Med Chem Lett
; 19(6): 1682-5, 2009 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19232492
10.
1,4-Dihydroindeno[1,2-c]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel.
J Med Chem
; 50(9): 2011-29, 2007 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-17425296
11.
Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides.
J Med Chem
; 60(16): 7123-7138, 2017 08 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-28759231
12.
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.
J Med Chem
; 60(9): 3828-3850, 2017 05 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28368119
13.
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
J Med Chem
; 60(20): 8369-8384, 2017 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-28949521
14.
Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists.
J Med Chem
; 49(15): 4459-69, 2006 Jul 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-16854051
15.
Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.
J Med Chem
; 49(12): 3563-80, 2006 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-16759099
16.
Current status and future prospects for enabling chemistry technology in the drug discovery process.
F1000Res
; 5: 2426, 2016.
Artículo
en Inglés
| MEDLINE | ID: mdl-27781094
17.
Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.
ACS Med Chem Lett
; 7(12): 1102-1106, 2016 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27994746
18.
Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.
J Med Chem
; 46(20): 4232-5, 2003 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-13678400
19.
Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.
J Med Chem
; 46(16): 3437-40, 2003 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-12877578
20.
Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.
J Med Chem
; 47(3): 612-26, 2004 Jan 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-14736242