Detalles de la búsqueda
1.
Cyanide Trapping of Iminium Ion Reactive Metabolites: Implications for Clinical Hepatotoxicity.
Chem Res Toxicol
; 37(5): 698-710, 2024 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38619497
2.
Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVß6 integrin occupancy using positron emission tomography in rodent lung.
Eur J Nucl Med Mol Imaging
; 47(4): 958-966, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31897589
3.
Translation of Inhaled Drug Optimization Strategies into Clinical Pharmacokinetics and Pharmacodynamics Using GSK2292767A, a Novel Inhaled Phosphoinositide 3-Kinase δ Inhibitor.
J Pharmacol Exp Ther
; 369(3): 443-453, 2019 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-30940692
4.
Design, Synthesis, and Evaluation of Lung-Retentive Prodrugs for Extending the Lung Tissue Retention of Inhaled Drugs.
J Med Chem
; 65(14): 9802-9818, 2022 07 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-35798565
5.
A way to decylamine-stabilized gold nanoparticles of tailored sizes tuning their growth in solution.
J Nanosci Nanotechnol
; 11(3): 2226-31, 2011 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-21449372
6.
Translational pharmacology of an inhaled small molecule αvß6 integrin inhibitor for idiopathic pulmonary fibrosis.
Nat Commun
; 11(1): 4659, 2020 09 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-32938936
7.
Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis.
J Med Chem
; 62(19): 8796-8808, 2019 10 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31497959
8.
Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvß6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.
J Med Chem
; 62(16): 7543-7556, 2019 08 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-31381331
9.
Size-controlled synthesis and NMR characterization of mesitylene-vinylsiloxanes stabilized Pt nanoparticles in solution.
J Nanosci Nanotechnol
; 8(4): 2096-101, 2008 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-18572620
10.
Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvß6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis.
J Med Chem
; 61(18): 8417-8443, 2018 09 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-30215258
11.
Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
J Med Chem
; 59(15): 7239-51, 2016 08 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-27429068
12.
Synthesis and biological evaluation of pro-drugs of GW196771, a potent glycine antagonist acting at the NMDA receptor.
Farmaco
; 60(5): 393-7, 2005 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15885689
13.
Glucose-coated superparamagnetic iron oxide nanoparticles prepared by metal vapour synthesis are electively internalized in a pancreatic adenocarcinoma cell line expressing GLUT1 transporter.
PLoS One
; 10(4): e0123159, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25874906
14.
Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.
J Med Chem
; 58(18): 7381-99, 2015 Sep 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-26301626
15.
Expression analysis of brain-derived neurotrophic factor (BDNF) mRNA isoforms after chronic and acute antidepressant treatment.
Brain Res
; 1000(1-2): 148-55, 2004 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-15053962
16.
Effect of the TRPV1 antagonist SB-705498 on the nasal parasympathetic reflex response in the ovalbumin sensitized guinea pig.
Br J Pharmacol
; 169(3): 580-9, 2013 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-23441756
17.
Molecular clinical safety intelligence: a system for bridging clinically focused safety knowledge to early-stage drug discovery - the GSK experience.
Drug Discov Today
; 16(15-16): 646-53, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21601652
18.
Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
J Med Chem
; 59(20): 9574, 2016 10 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-27726364
19.
Correction to Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
J Med Chem
; 59(17): 8148, 2016 09 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27548024
20.
p38alpha mitogen-activated protein kinase inhibitors: optimization of a series of biphenylamides to give a molecule suitable for clinical progression.
J Med Chem
; 52(20): 6257-69, 2009 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-19772287