Detalles de la búsqueda
1.
Synthesis of (22R)-, (22S)-22-Fluoro-, and 22,22-Difluoro-25-hydroxyvitamin D3 and Effects of Side-Chain Fluorination on Biological Activity and CYP24A1-Dependent Metabolism.
J Org Chem
; 88(17): 12394-12408, 2023 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37590101
2.
Synthesis of New 26,27-Difluoro- and 26,26,27,27-Tetrafluoro-25-hydroxyvitamin D3: Effects of Terminal Fluorine Atoms on Biological Activity and Half-life.
Chem Pharm Bull (Tokyo)
; 71(9): 717-723, 2023 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37423740
3.
Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by CYP24A1 and CYP3A using Cyp24a1 knockout rats generated by CRISPR/Cas9 system.
J Biol Chem
; 296: 100668, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33865853
4.
Comparison of the stability of CYP105A1 and its variants engineered for production of active forms of vitamin D.
Biosci Biotechnol Biochem
; 86(4): 444-454, 2022 Mar 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-35134837
5.
In Silico Prediction of the Metabolic Resistance of Vitamin D Analogs against CYP3A4 Metabolizing Enzyme.
Int J Mol Sci
; 23(14)2022 Jul 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-35887195
6.
The First Convergent Synthesis of 23,23-Difluoro-25-hydroxyvitamin D3 and Its 24-Hydroxy Derivatives: Preliminary Assessment of Biological Activities.
Molecules
; 27(16)2022 Aug 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36014588
7.
Chemical Synthesis of Side-Chain-Hydroxylated Vitamin D3 Derivatives and Their Metabolism by CYP27B1.
Chembiochem
; 22(19): 2896-2900, 2021 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34250710
8.
Rescue from Stx2-Producing E. coli-Associated Encephalopathy by Intravenous Injection of Muse Cells in NOD-SCID Mice.
Mol Ther
; 28(1): 100-118, 2020 01 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31607541
9.
Stereoselective Synthesis of 24-Fluoro-25-Hydroxyvitamin D3 Analogues and Their Stability to hCYP24A1-Dependent Catabolism.
Int J Mol Sci
; 22(21)2021 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34769295
10.
Development of In Vitro and In Vivo Evaluation Systems for Vitamin D Derivatives and Their Application to Drug Discovery.
Int J Mol Sci
; 22(21)2021 Oct 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-34769269
11.
Synthesis, CYP24A1-Dependent Metabolism and Antiproliferative Potential against Colorectal Cancer Cells of 1,25-Dihydroxyvitamin D2 Derivatives Modified at the Side Chain and the A-Ring.
Int J Mol Sci
; 21(2)2020 Jan 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-31963716
12.
Tumor-suppressive roles of ΔNp63ß-miR-205 axis in epithelial-mesenchymal transition of oral squamous cell carcinoma via targeting ZEB1 and ZEB2.
J Cell Physiol
; 233(10): 6565-6577, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29150940
13.
Protein engineering of CYP105s for their industrial uses.
Biochim Biophys Acta Proteins Proteom
; 1866(1): 23-31, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-28583351
14.
Whole-cell-dependent biosynthesis of sulfo-conjugate using human sulfotransferase expressing budding yeast.
Appl Microbiol Biotechnol
; 102(2): 723-732, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-29134333
15.
Alterations of Hepatic Metabolism in Chronic Kidney Disease via D-box-binding Protein Aggravate the Renal Dysfunction.
J Biol Chem
; 291(10): 4913-27, 2016 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-26728457
16.
Production of an active form of vitamin D2 by genetically engineered CYP105A1.
Biochem Biophys Res Commun
; 486(2): 336-341, 2017 04 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-28302483
17.
CXCL14-CXCR4 and CXCL12-CXCR4 Axes May Play Important Roles in the Unique Invasion Process of Endometrioid Carcinoma With MELF-Pattern Myoinvasion.
Int J Gynecol Pathol
; 36(6): 530-539, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28277316
18.
Sequential hydroxylation of vitamin D2 by a genetically engineered CYP105A1.
Biochem Biophys Res Commun
; 473(4): 853-858, 2016 05 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-27037023
19.
Biosynthesis of Drug Glucuronide Metabolites in the Budding Yeast Saccharomyces cerevisiae.
Mol Pharm
; 13(7): 2274-82, 2016 07 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-27241161
20.
Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D2 as Potential Anti-Leukemic Agents.
Int J Mol Sci
; 17(2)2016 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26840307