ABSTRACT
Five Ayurvedic medicines with mercury concentrations of 85mg/kg and higher were characterized with respect to their speciation and their bioaccessibility. X-ray absorption spectroscopy revealed that the mercury in the Ayurvedic medicines was inorganic and best matched to cinnabar, even in samples that had been hypothesized to contain mercury through plant sources only. The bioaccessibility (bioaccessible concentrations and percent bioaccessibility) was measured using two methods: a two-phase physiologically based extraction test (PBET gastric, G and gastric+intestinal phase, GI); and the fed organic estimation human simulation test (FOREhST). The percent bioaccessibility of mercury in all Ayurvedic samples was very low (<5%), corresponding to the low solubility of cinnabar, but it increased with increasing dissolved organic carbon content of the bioaccessibility solutions (PBET-GSubject(s)
Environmental Monitoring/methods
, Gastrointestinal Tract/metabolism
, Materia Medica/pharmacokinetics
, Medicine, Ayurvedic
, Mercury Compounds/pharmacokinetics
, Biological Availability
, Humans
, India
, Materia Medica/analysis
, Mercury Compounds/analysis
, Plant Extracts/analysis
, Plant Extracts/pharmacokinetics
, Risk Assessment/methods
, Spectrometry, X-Ray Emission
, X-Ray Absorption Spectroscopy