1.
Zhong Yao Cai
; 27(12): 914-5, 2004 Dec.
Article
in Zh
| MEDLINE
| ID: mdl-15807242
ABSTRACT
A polypeptide, SV-PP-2, was purified from Agkistrodon blomhoffii Bioe by HPLC C18 column. The SV-PP-2 has molecular weight of 23339.00 Da, and can inhibit the ADP-induced platelet aggregation in dose-dependent manner. There have been no such polypeptides reported yet which has inhibition of platelet aggregation and similar molecular weight to SV-PP-2.
Subject(s)
Agkistrodon , Materia Medica/pharmacology , Peptides/isolation & purification , Peptides/pharmacology , Platelet Aggregation Inhibitors/pharmacology , Snake Venoms/chemistry , Animals , Chromatography, High Pressure Liquid/methods , Dose-Response Relationship, Drug , Female , In Vitro Techniques , Male , Materia Medica/isolation & purification , Platelet Aggregation/drug effects , Platelet Aggregation Inhibitors/isolation & purification , Rabbits
2.
Zhong Yao Cai
; 27(11): 840-2, 2004 Nov.
Article
in Zh
| MEDLINE
| ID: mdl-15810593
ABSTRACT
This is the first report to purify a new peptide SV-PP-1 from Agkistrodon blomhoffii Bioe. SV-PP-1 has molecular weight of 1234.616 Da and can inhibit on platelet aggregation. SV-PP-1 significantly inhibited the ADP-induced platelet aggregation. It has been found up to now that SV-PP-1 is the smallest peptide inhibiting on platelet aggregation from snake venom.