ABSTRACT
Slicing is critical in the processing of Chinese materia medica(CMM) processed product and the specification(thickness) is closely related to the quality of the decoction. On the basis of clarifying the concept and evolution of slicing of CMM processed product by reviewing the Chinese herbal classics of the past dynasties and general rules of local processing standards, this study discussed the development history of slicing specifications in general rules of Chinese Pharmacopoeia(2020 edition), analyzed the current situation and key problems, and proposed the thinking and suggestion on promoting the sound development of slicing of CMM processed product. Since 2000, the slicing thickness of CMM processed product in the general rules of local CMM processed product processing specifications newly revised and issued by 27 provinces, autonomous regions, and municipalities has been consistent with that in the general rules of the Chinese Pharmacopoeia(2020 edition). The standard that the thickness of extremely thin pieces is less than 0.5 mm is rarely retained, and the pieces in 0.5-1 mm thickness have not been found on the market, which is consistent with the provisions of the general rules of the Chinese Pharmacopoeia. This study can provide a historical and modern basis for the rationality of slicing of CMM processed product.
Subject(s)
Drugs, Chinese Herbal , Materia Medica , Medicine, Chinese Traditional , Reference StandardsABSTRACT
Processing of Chinese materia medica is one of the important part of traditional Chinese medicine(TCM). Drugs in small pieces or slices are special for China and the whole world. Processing technic of Chinses materia medica existed for thousands of years and presented the essence of TCM. The purpose of analyzing the feature and development of traditional processing culture branches was to make a better understanding of traditional processing technic, and further the development of special processing culture branches.
Subject(s)
Materia Medica/chemistry , Medicine, Chinese Traditional/methodsABSTRACT
OBJECTIVE: To optimize the extracting condition of fatty constituents from Tabanus bivittatus and analyse by GC-MS. METHODS: Taking fatty yield as index, the extraction technology parameters of fatty constituents of Tabanus bivittatus ere optimized by single factor test and orthogonal test. RESULTS: The optimum extraction parameters were as follows: the ratio of acetone to petroleum ether 1: 2, extraction time 2 h, solid-liquid ratio 1: 50. Twenty-one fatty acids were identified by GC-MS. CONCLUSION: The process is reasonable and with good reproducibility. The main components of fatty acids in Tabanus bivittatus are palmitoleic acid, palmitic acid, linoleic acid, oleic acid and stearic acid.
Subject(s)
Diptera/chemistry , Fatty Acids/analysis , Materia Medica/analysis , Acetone/chemistry , Animals , Fatty Acids/isolation & purification , Gas Chromatography-Mass Spectrometry , Linoleic Acid/analysis , Materia Medica/isolation & purification , Oleic Acid/analysis , Palmitic Acid/analysis , Reproducibility of Results , Solvents/chemistry , Time FactorsABSTRACT
OBJECTIVE: To evaluate the release in fixed position of pH-dependent and enzyme-dependent Kangfuxin colon targeting capsules in vivo and in vitro. METHOD: The dissolution was tested in vitro and X-ray radiography was used for the evaluation in vivo. RESULT: After two hours pH-dependent colon targeting in man-made colon fluid, medicine release in fixed position on the whole, colon loc-release. Add enzyme into man-made colon, when enzyme-dependent colon targeting in it, then medicine release quickly, mainly release in fixed position; The conveying time in vivo of pH-dependent and enzyme-dependent capsules have big individuality difference. In the experiment, disintegration is stabilize among individuales, between 2.0-3.5 hours. CONCLUSION: Kangfuxin colon targeting capsules of two principles all release in fixed position to achieve the goal.
Subject(s)
Colon/metabolism , Drug Delivery Systems , Materia Medica/pharmacokinetics , Animals , Capsules , Colon/diagnostic imaging , Delayed-Action Preparations/chemistry , Drug Carriers , Female , Humans , Hydrogen-Ion Concentration , Male , Materia Medica/administration & dosage , Materia Medica/isolation & purification , Periplaneta/chemistry , Polygalacturonase/chemistry , RadiographyABSTRACT
OBJECTIVE: To prepare coated micro-pellets of pH-dependent and enzyme-dependent kangfuxin colon targeting delivery system, to make them go to colon, then release, educe partial effect. METHOD: We eploy pan-pill to prepare simple pellets, and prepare tunicatus pellets with fluidized bed coating. We investigated the preparation and parameter of pellets, so, we bolting the best shaping and tunicatus artwork. RESULT: The ingredients for preparing the micro-pellets are 125% starch +2% CMC-Na, and add 30% ethanol to be binder, pellets were coated with Eudragit S100 to prepare ph-dependent and pectin-HPMC to prepare enzyme-dependent colon targeting micro-pellets. CONCLUSION: We get two micro-pellets of pH-dependent and enzyme-dependent kangfuxin colon targeting.