The incidence of EEG abnormalities and outcome of infants paralyzed with neuromuscular blocking agents.

The EEGs of 40 infants paralyzed with D-tubocurarine or pancuronium during the neonatal period were reviewed retrospectively. The 23 infants who survived were re-examined at 1-3 yr of age. Sixteen infants had normal or mildly abnormal EEGs in the neonatal period; 3 died of nonneurologic causes; the remainder were normal at follow-up. Three of 8 infants with moderately abnormal EEGs in the neonatal period died, 2 had neurologic sequelae at follow-up, and 3 were normal at follow-up. Eleven of 16 infants with markedly abnormal EEGs died, and 5 had neurologic deficits at follow-up. Seizures occurred in 16 infants. Ten (63%) of the 16 died, whereas only 7 (29%) of 24 infants without seizures died (p less than .1). Eight infants had seizures only during paralysis. The EEG was statistically the best predictor of neurologic outcome when compared with the following variables recorded before paralysis: estimated gestational age (EGA), birth weight, Apgar score at 1 and 5 min, lowest PO2 and pH and highest PCO2. This study establishes the value of the EEG in the neurologic assessment of iatrogenically paralyzed newborns in the detection of seizures, and confirms previous studies which showed the value of EEG in predicting outcome.

Opiate v CNS depressant therapy in neonatal drug abstinence syndrome.

Paregoric and phenobarbital, administered randomly in 153 passively addicted neonates, initially appeared to control neonatal abstinence signs equally well. However, seven of the 62 phenobarbital-treated newborns had abstinence-associated seizures within the first month of life, while none of 49 paregoric-treated neonates had seizures. Forty-two neonates initially requiring no specific pharmacotherapy for abstinence signs were born to mothers taking less methadone hydrochloride just before delivery. Five of those 42 neonates, however, had seizures within the first 14 days of life. Seizure occurrence could not be predicted from analysis of early abstinence patterns. We consider paregoric to be the treatment of choice for the neonatal abstinence syndrome. Phenobarbital use should be monitored with serum drug levels and modification of recommended dosage regimens considered.

Neonatal seizures associated with narcotic withdrawal.

Among 302 neonates passively addicted to narcotics, 18 had seizures that were attributed to withdrawal. Of those 18 infants, 10 were among the 127 infants exposed to methadone (7.8%), whereas only one of them was among the 83 infants exposed to heroin (1.2%). Generalized motor seizures and myoclonic jerks were the predominant convulsive manifestations. Paregoric was more effective than was diazepam in controlling and preventing these seizures once they occurred. Electroencephalograms were obtained on 13 neonates in the interictal period; 12 of these ECGs were normal. Three infants, two with myoclonic jerks, had paroxysmal brain wave activity at the time of the seizures.

Convulsiones provocadas por noxas emocionales y afectivas / Convultions triggered by emotional and affective noxa

El presente trabajo refleja la eficacia de un medicamento homeopatico en el tratamiento de un caso de convulsiones, cuyo desencadenante fueron noxas afectivo-emocionales

Convulsiones provocadas por noxas emocionales y afectivas / Convulsion stimulate by emotional and affective noxas

El presente trabajo refleja la eficacia de un medicamento homeopático en el tratamiento de un caso de convulsiones cuyo desencadenante fueron noxas afectivo-emocionales

Convulsiones / Convulsions

Es menester conocerlas desde el punto de vista neurológico para discriminar en qué ocasiones se puede actuar con el tratamiento homeopático. Pero es importante tener en cuenta que aún en procesos orgánicos, puede ejercer alguna influencia, mejorando sobre todo el estado general. Siempre debemos intentarlo, sin descartar otro tipo de tratamiento