Antimonium Tartaricum as a Possible Homeopathic Prophylactic Remedy in the COVID-19 Epidemic.

The current COVID-19 (coronavirus disease 2019) epidemic has proved challenging due to its high impact on physical and mental health. According to Hahnemann, the founder of homeopathy, in an epidemic the most severe symptoms of the clinical condition presented by the population in question should be the basis for selecting the medication that is as similar as possible to them, and which should be administered to individuals who have been exposed to the disease but have not yet developed it. This medicine is called the genus epidemicus. This study aims to demonstrate the reasoning used to propose the homeopathic medicine Antimonium tartaricum (Ant-t) as a genus epidemicus in the COVID-19 epidemic. It was decided to develop the reasoning based on the respiratory symptoms described in the epidemiological bulletins presented by the Health Surveillance Secretariat of the Ministry of Health of Brazil, as these symptoms are the most serious of the disease. After repertorization, it was confirmed in the Materia Medica that Ant-t has a high degree of similarity with these respiratory symptoms, including the most serious situations, of COVID-19. Homeopathic Ant-t is thus a possible prophylactic genus epidemicus in the COVID-19 epidemic; further studies are needed to test this conclusion.

Homeopathic Prevention and Management of Epidemic Diseases.

BACKGROUND: Homeopathy has been used to treat epidemic diseases since the time of Hahnemann, who used Belladonna to treat scarlet fever. Since then, several approaches using homeopathy for epidemic diseases have been proposed, including individualization, combination remedies, genus epidemicus, and isopathy. METHODS: The homeopathic research literature was searched to find examples of each of these approaches and to evaluate which were effective. RESULTS: There is good experimental evidence for each of these approaches. While individualization is the gold standard, it is impractical to use on a widespread basis. Combination remedies can be effective but must be based on the symptoms of a given epidemic in a specific location. Treatment with genus epidemicus can also be successful if based on data from many practitioners. Finally, isopathy shows promise and might be more readily accepted by mainstream medicine due to its similarity to vaccination. CONCLUSION: Several different homeopathic methods can be used to treat epidemic diseases. The challenge for the future is to refine these approaches and to build on the knowledge base with additional rigorous trials. If and when conventional medicine runs out of options for treating epidemic diseases, homeopathy could be seen as an attractive alternative, but only if there is viable experimental evidence of its success.

[The understanding of epidemic diseases in the Qin and Han Dynasties].

In the Qin and Han Dynasties, three views were argued as the main causes of epidemic diseases, the observation of climate, the interaction between nature and humans and 'witchcraft'. Specifically it was thought that abnormal climate, personnel and government decree, and 'gods' and 'ghosts' were responsible for epidemics. This perception led to corresponding countermeasures to deal with epidemic diseases. The abnormal climate in nature was believed to result in the occurrence of epidemic diseases. This was interpreted by traditional Chinese medicine in terms of exogenous diseases. For instance, Huang Di Nei Jing interpreted leprosy with the point of wind-pathogen attacking. Shang Han Lun treated epidemic diseases with the viewpoint of exogenous pathogen. The classic books of Chinese materia medica recorded many cases of preventing and treating epidemic diseases with materia medica. The personnel and government decree refers to the wrong decrees of Emperors and the poor implementation of officials. This was argued to lead to various disasters including epidemic diseases. It was interpreted by Dong Zhongshu, a famous Confucian in the Han Dynasty, as the punishment of gods upon their misconduct. This reminded emperors about reflecting on the epidemic diseases and correcting their mistakes politically. 'Gods' and 'ghosts' were also believed as the cause of epidemics. This idea drove people to deal with epidemic diseases through sacrifices and exorcism.

The DARK Side of Total Synthesis: Strategies and Tactics in Psychoactive Drug Production.

Humankind has used and abused psychoactive drugs for millennia. Formally, a psychoactive drug is any agent that alters cognition and mood. The term "psychotropic drug" is neutral and describes the entire class of substrates, licit and illicit, of interest to governmental drug policy. While these drugs are prescribed for issues ranging from pain management to anxiety, they are also used recreationally. In fact, the current opioid epidemic is the deadliest drug crisis in American history. While the topic is highly politicized with racial, gender, and socioeconomic elements, there is no denying the toll drug mis- and overuse is taking on this country. Overdose, fueled by opioids, is the leading cause of death for Americans under 50 years of age, killing ca. 64,000 people in 2016. From a chemistry standpoint, the question is in what ways, if any, did organic chemists contribute to this problem? In this targeted review, we provide brief historical accounts of the main classes of psychoactive drugs and discuss several foundational total syntheses that ultimately provide the groundwork for producing these molecules in academic, industrial, and clandestine settings.

Genus Epidemicus: Are Notions of Entanglement Relevant to the Homeopathic Understanding of Epidemic Disease?

BACKGROUND: Patient-practitioner-remedy (PPR) entanglement postulates non-local triadic interaction between patient (Px), practitioner (Pr) and potentised medicine (Rx), resulting in the patient's journey to cure; the in-depth homeopathic interview is considered a major contributing factor in this process. Also, by modelling entelechy, a quantised gyroscopic analogue of the Vital Force (Vf) has been developed. OBJECTIVE: To discover whether entanglement notions explain the mode of action of homeopathy during the treatment of epidemic diseases, when the individualising in-depth homeopathic interview is neither possible nor necessary. METHOD: The current Vf wave equation applies specifically to the in-depth patient/practitioner consultation in chronic dis-ease. A generalised form of the Vf wave equation, an earlier hypothesis based on quantum field theory (QFT) and PPR entanglement were all re-investigated. RESULTS: The generalised Vf wave equation was found applicable in 3 main conditions: acute self-limiting, chronic and epidemic dis-ease. In the latter, a single, coherent Vf epidemic 'wave function' covering all susceptible beings could be identified, which, after practitioner intervention, disappears. Analogies were drawn between groups of atoms in a p-doped semiconductor and a collection of susceptible beings in an epidemic. Here, genus epidemicus is likened to an 'n-type dopant', which forms a 'p-n junction' with the dis-ease. Using the QFT hypothesis/metaphor, genus epidemicus acts as a 'gauge field' restoring 'global invariance' to the symmetry-broken, symptom-expressing Vf, i.e., restoring health. CONCLUSION: Entanglement hypotheses/metaphors may have application in the homeopathic therapeutic process beyond the one-to-one in-depth interview, and so are relevant to describing the mode of action of homeopathy during treatment of epidemic disease.

The frightening borderlands of Enlightenment: the vampire problem.

Between 1724 and 1760, in the frontier area of the Habsburg empire waves of a hitherto unknown epidemic disease emerged: vampirism. In remote villages of southeastern Europe, cases of unusual deaths were reported. Corpses did not decay and, according to the villagers, corporeal ghosts were haunting their relatives and depriving them of their vital force. Death occurred by no later than three to four days. The colonial administration, alarmed by the threat of an epidemic illness, dispatched military officers and physicians to examine the occurrences. Soon several reports and newspaper articles circulated and made the untimely resurrection of the dead known to the perplexed public, Europe-wide. "Vampyrus Serviensis", the Serbian vampire, became an intensively discussed phenomenon within academe, and thereby gained factual standing. My paper depicts the geopolitical context of the vampire's origin within the Habsburg states. Secondly, it outlines the epistemological difficulties faced by observing physicians in the field. Thirdly, it delineates the scholarly debate on the apparent oxymoron of the living dead in the era of enlightened reason. Fourthly, the early history of vampirism shows that ghosts and encounters with the undead are not superstitious relics of a pre-modern past, or the Enlightenment's other, but intimate companions of Western modernity.

O desequilibrio emocional nas epidemias: a contribuição homeopática

As epidemias provocam repercussões psicológicas além da doença física. O presente trabalho de revisão bibliográfica apresenta os sintomas mentais e emocionais dos indivíduos no enfrentamento das epidemias e apresenta a Homeopatia como uma ciência possivelmente eficaz para o seu tratamento, com identificação das rubricas repertoriais que abrangem os sintomas mais comuns. A Homeopatia pode ser um tratamento vasto, compatível, individualizado e eficaz para o enfrentamento dessa situação, melhora da qualidade de vida e funcionalidade do sujeito.(AU)

Epidemics have psychological repercussions in addition to physical illness. The present bibliographic review presents the mental and emotional symptoms of individuals in facing epidemics and presents Homeopathy as a possibly effective science for its treatment, with identification of repertoire rubrics that cover the most common symptoms. Homeopathy can be a vast, compatible, individualized and effective treatment to face this situation, improving the subject's quality of life and functionality.(AU)

Clinical research protocol to evaluate the effectiveness and safety of individualized homeopathic medicine in the treatment and prevention of the COVID-19 epidemic

In addition to the recognized application in chronic diseases, individualized homeopathy can also act in a resolutive or complementary way in acute cases, including epidemic diseases. However, to achieve this intent, it presents a specific semiologic and therapeutic methodology that must be followed and respected, with the risk of not presenting the desired efficacy and safety. In the case of epidemic diseases, which due to the virulence of their agents causes a common symptomatological picture in most susceptible individuals, the individualized homeopathic medicine (homeopathic medicine of the epidemic genius) should present similarity with the set of characteristic symptoms and signs of the patients affected in the different stages of each epidemic outbreak. Studies show the efficacy and safety of this prophylactic and/or therapeutic practice in several epidemics of the past. Therefore, after the survey of possible homeopathic drugs individualized from the epidemic genius of each epidemic, its prophylactic and/or large-scale therapeutic application should be supported by previous clinical trials that demonstrate its efficacy and safety, in line with the ethical and bioethical aspects of research involving human beings. Fulfilling these premises of good clinical practice, we developed the current protocol with the objective of investigating, in a randomized, double-blind and placebo-controlled clinical trial, the effectiveness and safety of possible individualized homeopathic drugs of epidemic genius of COVID-19, in adjuvant and complementary treatment of patients affected by the disease. If effectiveness and safety are confirmed, and only in this condition, the medicine may be used in a generalized and collective manner in the treatment and prevention of the current epidemic. (AU)

Protocolo de pesquisa clínica para avaliar a eficácia e a segurança de medicamento homeopático individualizado no tratamento e na prevenção da epidemia de COVID-19 / Clinical research protocol to evaluate the efficacy and safety of individualized homeopathic medicine in the treatment and prevention of the COVID-19 epidemic

Além da reconhecida aplicação nas doenças crônicas, a homeopatia individualizada também pode atuar de forma resolutiva ou complementar nos casos agudos, incluindo as doenças epidêmicas. No entanto, para atingir esse intento, apresenta uma metodologia semiológica e terapêutica específica que deve ser seguida e respeitada, com o risco de não apresentar a eficácia e a segurança desejada. No caso das doenças epidêmicas, que pela virulência dos seus agentes provoca um quadro sintomatológico comum na maioria dos indivíduos suscetíveis, o medicamento homeopático individualizado (medicamento homeopático do gênio epidêmico) deve apresentar semelhança com o conjunto de sinais e sintomas característicos dos pacientes acometidos nos diferentes estágios de cada surto epidêmico. Estudos evidenciam a eficácia e a segurança desta prática profilática e/ou terapêutica em diversas epidemias do passado. Assim sendo, após o levantamento dos possíveis medicamentos homeopáticos individualizados do gênio epidêmico de cada epidemia, sua aplicação profilática e/ou terapêutica em larga escala deve ser sustentada por ensaios clínicos prévios que demonstrem sua eficácia e segurança, em consonância com os aspectos éticos e bioéticos da pesquisa envolvendo seres humanos. Cumprindo essas premissas da boa prática clínica, elaboramos o atual protocolo com o objetivo de investigar, em ensaio clínico randomizado, duplo-cego e placebo-controlado, a eficácia e a segurança de possíveis medicamentos homeopáticos individualizados do gênio epidêmico da COVID-19, em tratamento adjuvante e complementar de pacientes acometidos pela doença. Caso a a eficácia e a segurança se confirme, e tão somente, o(s) medicamento(s) poderão ser utilizado de forma generalizada e coletiva no tratamento e na prevenção da atual epidemia. (AU)

In addition to the recognized application in chronic diseases, individualized homeopathy can also act in a resolutive or complementary way in acute cases, including epidemic diseases. However, to achieve this intent, it presents a specific semiological and therapeutic methodology that must be followed and respected, with the risk of not presenting the desired efficacy and safety. In the case of epidemic diseases, which due to the virulence of their agents causes a common symptomatological picture in most susceptible individuals, the individualized homeopathic medicine (homeopathic medicine of the epidemic genius) should present similarity with the set of characteristic symptoms and signs of the patients affected in the different stages of each epidemic outbreak. Studies show the efficacy and safety of this prophylactic and/or therapeutic practice in several epidemics of the past. Therefore, after the survey of possible homeopathic drugs individualized from the epidemic genius of each epidemic, its prophylactic and/or large-scale therapeutic application should be supported by previous clinical trials that demonstrate its efficacy and safety, in line with the ethical and bioethical aspects of research involving human beings. Fulfilling these premises of good clinical practice, we developed the current protocol with the objective of investigating, in a randomized, double-blind and placebo-controlled clinical trial, the efficacy and safety of possible individualized homeopathic drugs of epidemic genius of COVID-19, in adjuvant and complementary treatment of patients affected by the disease. If efficacy and safety are confirmed, and only in this condition, the medicine may be used in a generalized and collective manner in the treatment and prevention of the current epidemic. (AU)