ABSTRACT
PURPOSE: To review the published literature to determine the efficacy and safety of homeopathic agents or vitamins in reducing ecchymosis after oculofacial surgery or laser surgery. METHODS: A literature search was conducted in the PubMed database initially in December 2019 and updated in March 2020 to identify all studies in the English language literature on the use of homeopathic agents or vitamins in oculofacial procedures, including laser surgery. The search yielded 124 citations, and 11 articles met all inclusion criteria for this assessment. A panel methodologist then assigned a level of evidence rating for each study. Eleven studies met inclusion criteria; 9 were rated level I, and 2 were rated level III. RESULTS: The agents studied in the articles identified included oral or topical Arnica montana (AM), oral Melilotus extract, topical vitamin K oxide, and topical AM combined with Rhododendron tomentosum. Metrics to describe ecchymosis varied. In 7 controlled studies, perioperative AM provided no or negligible benefit versus placebo. In 2 studies, vitamin K cream was equivalent to placebo. One study of oral Melilotus extract had less ecchymosis compared with controls in paranasal and eyelid ecchymosis at postoperative day (POD) 7, but not at PODs 1 and 4. A lone cohort study of combined topical AM and R. tomentosum lacked objective metrics and adequate controls. No serious side effects from administration of homeopathic agents or vitamins were identified. CONCLUSIONS: The current literature does not support the use of AM, vitamin K oxide, R. tomentosum, or Melilotus extract for reducing ecchymosis after oculofacial surgery or pulsed dye laser surgery.
Subject(s)
Ecchymosis/drug therapy , Materia Medica/therapeutic use , Ophthalmologic Surgical Procedures/adverse effects , Plant Extracts/therapeutic use , Vitamin K/therapeutic use , Academies and Institutes/standards , Ecchymosis/etiology , Eyelid Diseases/surgery , Face/surgery , Humans , Ophthalmology/organization & administration , Paranasal Sinus Diseases/surgery , Technology Assessment, Biomedical , United StatesABSTRACT
Methods of conservative and complex rehabilitation of patients with cicatricial eyelid malpositions are proposed. Conservative treatment included developed regimen of antihomotoxic agents, different techniques of graduated extension of scar tissues, special eyelid exercises. In complex management conservative treatment was provided along with surgery, in some cases botulinum toxin A was administered. Duration, time and priorities were determined.
Subject(s)
Blepharoplasty/methods , Botulinum Toxins, Type A , Cicatrix/therapy , Drug Therapy/methods , Eyelid Diseases/therapy , Eyelids/surgery , Minerals , Plant Extracts , Adolescent , Adult , Aged , Botulinum Toxins, Type A/administration & dosage , Botulinum Toxins, Type A/adverse effects , Cicatrix/complications , Cicatrix/pathology , Cicatrix/physiopathology , Combined Modality Therapy , Eyelid Diseases/etiology , Eyelid Diseases/physiopathology , Eyelids/physiopathology , Female , Humans , Male , Materia Medica/administration & dosage , Materia Medica/adverse effects , Middle Aged , Minerals/administration & dosage , Minerals/adverse effects , Neuromuscular Agents/administration & dosage , Neuromuscular Agents/adverse effects , Plant Extracts/administration & dosage , Plant Extracts/adverse effects , Treatment OutcomeABSTRACT
Identification and determination of borneol and isoborneol in ointment Liyan Gao by TLC and GC were carried out. L-borneol standard substance and external standard one-point method were used for the determination. The recommended method is precise and simple.