Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add more filters

Database
Language
Publication year range
1.
Diabetes Care ; 10(3): 343-7, 1987.
Article in English | MEDLINE | ID: mdl-3297579

ABSTRACT

The stability of a new insulin formulation (lyophilized U100 insulin, Organon) was investigated in vitro in conditions reproducing those of in vivo implanted devices, i.e., constant horizontal agitation at 37 degrees C for 4 wk in various containers and 8 wk in different solvents. Physical stability was assessed by ultraviolet absorption, chemical stability by HPLC, and biological stability by hypoglycemia tests in mice. Insulin precipitated in glass vials but remained clear and active in polyethylene reservoirs and after passage through catheter and pumps in motion, although only 83-90% of insulin was delivered chemically intact. In acidic solvent, insulin showed a major gradual transformation into deamidized derivatives (up to 78% after 8 wk), although still fully active and clear, as expected from previously published excellent in vivo results with acidic insulins. Heparin addition to neutral insulin solution (500 IU/ml) did not alter the properties of the two compounds and might thus be tried to prevent in vivo catheter obstruction due to fibrin deposition.


Subject(s)
Insulin Infusion Systems , Insulin , Chromatography, High Pressure Liquid , Drug Incompatibility , Drug Packaging , Drug Stability , Freeze Drying , Heparin , Hydrogen-Ion Concentration , Nephelometry and Turbidimetry , Solvents
2.
Am J Forensic Med Pathol ; 25(2): 159-60, 2004 Jun.
Article in English | MEDLINE | ID: mdl-15166770

ABSTRACT

Microprocessor-controlled insulin pumps designed for continuous delivery of short-acting insulin analogs into subcutaneous tissues offer several important potential benefits for diabetic patients. The delivery of other substances using these systems is technically feasible. We present a case of homicide involving lethal doses of etomidate and atracurium injected via the victim's insulin pump. This unique situation could be encountered by homicide investigators more frequently as the popularity of these systems continues to grow.


Subject(s)
Homicide , Insulin Infusion Systems , Analgesics, Opioid/administration & dosage , Analgesics, Opioid/analysis , Analgesics, Opioid/poisoning , Anesthetics, Intravenous/administration & dosage , Anesthetics, Intravenous/analysis , Anesthetics, Intravenous/poisoning , Diabetes Mellitus, Type 2/drug therapy , Drug Overdose , Etomidate/administration & dosage , Etomidate/analysis , Etomidate/poisoning , Humans , Isoquinolines/administration & dosage , Isoquinolines/analysis , Isoquinolines/poisoning , Male , Methods , Middle Aged , Opium/administration & dosage , Opium/analysis , Opium/poisoning
SELECTION OF CITATIONS
SEARCH DETAIL