Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
1.
Arch Oral Biol ; 36(7): 549-52, 1991.
Article in English | MEDLINE | ID: mdl-1837983

ABSTRACT

The composition and flow rate of paraffin-stimulated whole saliva were analysed in 22 women, of whom 11 used oral contraceptives and 11 did not. Ten men served as the controls. The salivary samples were collected during one month (oral contraceptive users and men), or during one menstrual cycle (non-users). The saliva analyses included flow rate, pH, buffer effect, sialic acid, thiocyanate, peroxidase, lysozyme, amylase, immunoglobulins A, G and M, total protein, mutans streptococci, lactobacilli, yeasts and total numbers of aerobic bacteria. The salivary buffer effect of oral contraceptive users was significantly (p less than 0.005) higher than that of non-users. All the other constituents showed intra- and interindividual variation in all groups, but with no apparent hormone-dependency.


PIP: The flow rate and composition of whole saliva were analyzed in 11 women using low dose oral contraceptives in comparison with 11 menstruating women and 10 men. Paraffin-stimulated whole saliva samples were collected Monday, Wednesday and Friday mornings for 1 cycle or 1 month in all subjects, checked for pH and buffer effect (Dentobuff method, Orion Diagnostics, Espoo, Finland, a measure of bicarbonate content) immediately, and frozen for later assay of salivary lysozyme, amylase, peroxidase, thiocyanate, sialic acid, total protein, IgA, IgG, IgM, Mutans streptococci, Lactobacilli, yeasts and aerobic bacteria. The oral contraceptives taken were Marvelon (Organon, Holland) by 4 subjects, Microgynon (Leiras, Finland) by 1, and Trikvilar (Leiras) by 6. The only significant differences between subject groups of cycle phases was a higher salivary buffer effect in oral contraceptive users than that seen in non-users, who resembled male controls. There was a wide individual variation in most values, but less variation in pH and buffer effect. Salivary buffer effect, which is correlated with HCO3-content and salivary flow, is also higher in late pregnancy.


Subject(s)
Contraceptives, Oral/pharmacology , Saliva/drug effects , Adult , Buffers , Contraceptives, Oral/administration & dosage , Contraceptives, Oral, Combined , Contraceptives, Oral, Hormonal/administration & dosage , Contraceptives, Oral, Hormonal/pharmacology , Contraceptives, Oral, Synthetic/administration & dosage , Contraceptives, Oral, Synthetic/pharmacology , Desogestrel , Drug Combinations , Ethinyl Estradiol/administration & dosage , Ethinyl Estradiol/pharmacology , Ethinyl Estradiol-Norgestrel Combination , Female , Humans , Levonorgestrel/administration & dosage , Levonorgestrel/pharmacology , Male , Menstrual Cycle , Menstruation , Norgestrel/administration & dosage , Norgestrel/pharmacology , Norpregnenes/administration & dosage , Norpregnenes/pharmacology , Ovulation , Progesterone Congeners/administration & dosage , Progesterone Congeners/pharmacology , Saliva/chemistry , Saliva/metabolism , Salivary Proteins and Peptides/analysis , Salivary Proteins and Peptides/drug effects
2.
J Altern Complement Med ; 19(2): 161-9, 2013 Feb.
Article in English | MEDLINE | ID: mdl-22963271

ABSTRACT

OBJECTIVES: Stress impacts on health, causing stress-related illness. The aim of this study was to investigate stress dampening effects of the homeopathic combination remedy dysto-loges(®) S on physiological and psychological measures during acute stress. Additionally, effects of the substance on sleep and life quality were investigated. DESIGN: This randomized, double-blind, placebo-controlled single center study had a total duration of 15 days for each participant. SETTING/LOCATION: The study was performed by Daacro, Trier, Germany. SUBJECTS: We included 40 women aged 30-50 years that regularly experienced impaired well-being when feeling stressed. INTERVENTION: Participants took three tablets daily for 14 days. On the final study day, participants took three pills in the morning and upon arrival at the study site. Thereafter, the Trier Social Stress Test (TSST) was performed. OUTCOME MEASURES: Primary endpoints were saliva cortisol responses to the stress test. Secondary biological endpoints were plasma cortisol, adrenocorticotrophic hormone, epinephrine, and norepinephrine (NE) and heart rates. Psychological secondary endpoints were well-being, anxiety, stress, and insecurity during the stress test as well as sleep and quality of life. RESULTS: Stress-induced cortisol levels did not differ between groups, but verum-treated participants were characterized by lower NE levels. Two weeks of treatment with the homeopathic substance resulted in a better sleep quality. Sleep improvement was associated with a higher hormonal response to the TSST in both groups. In addition, individuals with impaired sleep in the placebo group had higher unstimulated NE levels. CONCLUSIONS: This study provides preliminary evidence for beneficial effects of dysto-loges S on sleep quality. Improvement of sleep quality was positively associated with a normalized neuroendocrine stress response during acute stress, whereas an altered hormonal response was observed in participants with impaired sleep. We hypothesize that the test product may possibly reduce NE release.


Subject(s)
Adrenocorticotropic Hormone/blood , Homeopathy , Hydrocortisone/metabolism , Materia Medica/therapeutic use , Norepinephrine/blood , Sleep/drug effects , Stress, Psychological/drug therapy , Acute Disease , Adult , Double-Blind Method , Female , Health Status , Humans , Hydrocortisone/blood , Saliva/metabolism , Sleep Wake Disorders/drug therapy , Sleep Wake Disorders/metabolism , Stress, Psychological/blood , Stress, Psychological/metabolism
3.
Homeopathy ; 94(3): 175-81, 2005 Jul.
Article in English | MEDLINE | ID: mdl-16060203

ABSTRACT

Twenty-eight patients with xerostomia participated in a blind, placebo-controlled longitudinal study of the possible effects of homeopathic medicines on oral discomfort. All patients were first divided in two groups according to their medication. After that the two groups were randomly assigned according to a coin-toss to the experimental or control group. Most patients had systemic diseases, such as rheumatoid arthritis and/or Sjögren's syndrome, and frequent daily medications. The randomly selected experimental group (n=15) got an individually prescribed homeopathic medicine and the control group (n=13) a placebo substance (sugar granules), both for 6 weeks. Neither group knew of the nature of the medicine. Oral dryness was evaluated by measurement of unstimulated and wax-stimulated salivary flow rates and visual analogue scale. With only two exceptions, the experimental group experienced a significant relief of xerostomia whereas no such effect was found in the placebo group. Stimulated salivary flow rate was slightly higher with homeopathy than placebo but no consistent changes occurred in salivary immunoglobulin (IgA, IgG) levels. In an open follow-up period those receiving homeopathic medicine continued treatment and the placebo group patients were treated with individually prescribed homeopathic medicines. The symptoms of xerostomia improved in both groups. Our results suggest that individually prescribed homeopathic medicine could be a valuable adjunct to the treatment of oral discomfort and xerostomic symptoms.


Subject(s)
Homeopathy/methods , Saliva/drug effects , Salivation/drug effects , Xerostomia/drug therapy , Adult , Arthritis, Rheumatoid/complications , Dose-Response Relationship, Drug , Female , Finland , Humans , Male , Middle Aged , Pain Measurement , Saliva/metabolism , Secretory Rate/drug effects , Sjogren's Syndrome/complications , Time Factors , Treatment Outcome , Xerostomia/prevention & control
4.
Acta odontol. venez ; 37(2): 21-6, mayo-ago. 1999. ilus, tab
Article in Spanish | LILACS | ID: lil-288452

ABSTRACT

En este estudio se evaluó la frecuencia y biotipos de Cándida sp. en la saliva de portadores sanos, tomando en consideración la actividad cariogénica de dichos individuos a través de informaciones epidemiológicas. La muestra consistió en 239 niños tomados al azar, divididos en cinco estratos sociales. La saliva de cada uno de estos pacientes fue, cultivadas en medios específicos para el crecimiento del hongo. Posterior al crecimiento de las levaduras, las mismas fueron identificadas bioquímicamente mediante pruebas de fermentación. Los resultados obtenidos demostraron que Cándida albicans fue la especia de mayor prevalencia en todas las categorías socioeconómicas evaluadas. En 5 por ciento de las muestras se evidenció la presencia de más de una especie de Cándida coexistiendo en la cavidad bucal, incluyendo asociación de C. albicans con C. tropicalis, C. parapsilosis y C. krusei. En ninguno de los casos las especies fueron detectadas individualmente


Subject(s)
Humans , Male , Female , Biotypology , Candida albicans/isolation & purification , Saliva/microbiology , Saliva/metabolism , Brazil , Culture Media , Dental Caries/epidemiology , Fermentation , Random Allocation , Socioeconomic Factors
SELECTION OF CITATIONS
SEARCH DETAIL