RESUMEN
OBJECTIVE: To investigate nourishing-yin effect and mechanism of different parts of Cornu Elaphuri Davidiani in rats. METHOD: The model of yin asthenia rats was built by thy roxine. The substance metabolism, pain threshold, hormone levels and biochemical indicators in serum were measured. RESULTS: The ethanol extract of Cornu Elaphuri Davidiani could regulate the substance metabolism and raise the pain threshold in yin asthenia model rats. Furthermore, it could regulate the hormone levels, biochemical indicators in serum and it could improvte the antioxidant ability. CONCLUSION: The ethanol extract of Cornu Elaphuri Davidiani showed significant nourishing-yin effect in rats and the possible mechanism is correlated with regulating the neuroendocrine network.
Asunto(s)
Cuernos de Venado , Ciervos , Hipertiroidismo/tratamiento farmacológico , Materia Medica/farmacología , Deficiencia Yin/tratamiento farmacológico , Hormona Adrenocorticotrópica/sangre , Animales , Modelos Animales de Enfermedad , Estradiol/sangre , Etanol/química , Femenino , Hipertiroidismo/sangre , Hipertiroidismo/inducido químicamente , Interleucina-2/sangre , Masculino , Materia Medica/administración & dosificación , Medicina Tradicional China , Umbral del Dolor/efectos de los fármacos , Distribución Aleatoria , Ratas , Ratas Sprague-Dawley , Superóxido Dismutasa/sangre , Testosterona/sangre , Tiroxina/efectos adversos , Deficiencia Yin/sangre , Deficiencia Yin/inducido químicamenteRESUMEN
OBJECTIVE: To establish the analytical method for the fingerprint pattern of Cornu Elaphuri Davidiani by X-ray diffraction. METHODS: Cornu Elaphuri Davidiani from different ages and different parts were analyzed and the fingerprint patterns were determined by X-ray diffraction. The degree of different fingerprint patterns was calculated and analyzed. RESULTS: The reference X-ray diffraction Fourier fingerprint pattern and characteristic diffraction peaks of Cornu Elaphuri Davidiani were obtained by fifteen samples of Cornu Elaphuri Davidiani from different ages and different parts. CONCLUSION: This method can be used for identification and evaluation of Cornu Elaphuri Davidiani.