RESUMEN
OBJECTIVE: To study the effects of deer tendons collagen on osteoporosis rats induced by retinoic acid. METHODS: Male Wistar rats were randomly divided into normal control group, model control group, deer tendons collagen high, medium and low-dose groups, osteoporosis rats of retinoic acid-induced were set up. Changes of body weight, bone weight, bone mineral density, bone histomorphometry, plasma phosphorus, calcium, alkaline phosphatase (ALP), bone mechanics were measured before and after treatment of deer tendons collagen. RESULTS: Compared with model control group,after treated by deer tendons collagen, body weight, bone mineral density, bone weight was increased in varying degrees, bone histomorphometry parameters were significantly different, the ALP in plasma was significantly reduced, contents of Ca, P were increased, all indicators of bone mechanics were significantly higher. CONCLUSION: Deer tendons collagen can prevent and treat retinoic acid-induced osteoporosis of rats.
Asunto(s)
Densidad Ósea/efectos de los fármacos , Colágeno/uso terapéutico , Ciervos , Fémur/efectos de los fármacos , Materia Medica/uso terapéutico , Osteoporosis/tratamiento farmacológico , Fosfatasa Alcalina/sangre , Fosfatasa Alcalina/metabolismo , Animales , Fenómenos Biomecánicos , Calcio/sangre , Colágeno/aislamiento & purificación , Colágeno/farmacología , Modelos Animales de Enfermedad , Fémur/metabolismo , Masculino , Materia Medica/farmacología , Osteoporosis/inducido químicamente , Osteoporosis/prevención & control , Distribución Aleatoria , Ratas , Ratas Wistar , Tendones , TretinoinaRESUMEN
Many patients mechanically ventilated for acute respiratory failure, are treated with medication that includes a combination of cortico-steroids and non-depolarizing neuromuscular-blocking agents (NNBa). A third of them can be expected to develop delayed neuromuscular damage, which may be severe and prolonged. We describe a 50-year-old man who suffered from acute myeloid leukemia and was ventilated due to pneumonia. He was treated with pancuronium and cortico-steroids, and during recovery suffered quadriparesis that lasted several months. Typically this damage is purely motor and is accompanied by absent tendon-reflexes, sometimes with elevated creatine-kinase. Muscle biopsy usually shows deletion and degeneration of thick myosin filaments. The phenomenon is related to the duration of NNBa treatment, and probably results from an adverse synergistic effect on muscle tissue of the cortico-steroids and cortico-steroid-like NNBa given the immobilized patient. Awareness of this adverse effect of steroids and pancuronium, the use of passive mobilization, shortening the use of NNBa and early rehabilitation would minimize disability due to this phenomenon.