RESUMO
Pseudocholinesterase activity was investigated in three groups of unselected patients. A slight rise of the enzyme was found during surgery under local anesthesia with lidocaine. In general anesthesia with thiopentone and halothane, the pseudocholinesterase activity diminished. The inhibition was more pronounced when pancuronium had been injected. From these data one may conclude that pancuronium must be carefully given in patients with low level of pseudocholinesterase when other drugs inhibiting the enzyme activity, like succinylcholine, procaine and propanidid, are used.
Assuntos
Anestesia por Inalação/efeitos adversos , Anestesia Local/efeitos adversos , Butirilcolinesterase/sangue , Colinesterases/sangue , Pancurônio/efeitos adversos , Halotano/efeitos adversos , Humanos , Lidocaína/efeitos adversos , Succinilcolina/efeitos adversos , Tiopental/efeitos adversosRESUMO
Requirements of pancruonium were evaluated in 50 adult patients undergoing abdominal surgery in halothane anaesthesia. A significant negative correlation was found between gamma-globulin and the apnoeic dose of pancuronium (r = --0.335, P less than 0.02), on the one hand, and the apnoeic period after it (r = --0.311, P less than 0.05), on the other hand. beta-Globulin displayed a significant positive correlation with the apnoeic period after pancuronium (r = 0.344, P less than 0.02). The heavier patients necessitated less drug/kg bw. to obtain apnoea than the leaner ones did. Finally, the females showed a higher sensitivity to pancuronium in comparison to the males.
Assuntos
Pancurônio/administração & dosagem , Adulto , Idoso , Envelhecimento , Anestesia , Proteínas Sanguíneas/metabolismo , Peso Corporal , Feminino , Halotano , Humanos , Masculino , Pessoa de Meia-Idade , Relaxamento Muscular/efeitos dos fármacos , Pancurônio/sangue , Ligação Proteica , Fatores de TempoRESUMO
The acetylcholinesterase activity was followed, as a variant of true cholinesterase, in three groups on non-selected patients: 10 of these were under local anesthesia with lidocaine, 12 were under general anesthesia with thiopenthal and halotane and 43 were under the same type of general anesthesia, that had also been given Pancuronium as a muscle relaxant. A slight inhibition was noted of the enzyme activities in the course of local anesthesia and a more significant one in the course of general anesthesia. The enzyme concentrations were lower in those patients that had also received Pancuronium, suggesting a cummulative inhibitory effect on serum acetylcholinesterase. The changes were not significant from the statistical viewpoint.