RESUMO
The authors consider systematic responsiveness in chronic opisthorchiasis and a relationship between acute inflammation and responsiveness. A number of regularities that take place in the patho- and sanogenesis of chronic disease in general and that are important in the evaluation of the severity and prognosis of the disease and the efficiency of therapy are demonstrated on a model of severe opisthorchiasis. The reversion syndrome indicative of recovered responsiveness during therapy is described in detail. Differences in the interpretation of the helminthoovoscopic findings are shown in the context of the priority of clinical data.
Assuntos
Opistorquíase/fisiopatologia , Opistorquíase/terapia , Opisthorchis/fisiologia , Fósforo/uso terapêutico , Animais , Biomarcadores/análise , Doença Crônica , Homeopatia , Interações Hospedeiro-Parasita , Humanos , Inflamação/fisiopatologia , Masculino , Pessoa de Meia-Idade , Opistorquíase/parasitologia , Opisthorchis/isolamento & purificação , Prognóstico , Resultado do TratamentoRESUMO
The authors propose a new treatment policy for opisthorchiasis, which is intended for the body's self-regulation and based on the use of antihomotoxic therapy. Forty patients with the verified diagnosis of chronic opisthorchiasis were examined. Antihomotoxic therapy was found to have high clinical (85%) and parasitological (75%) effects, The application of an aggregate clinical estimate showed a positive role of episodes of development of acute inflammatory reactions, fever, and reversion of prior diseases, which favors the restoration of the body's responsiveness and the particular efficiency of the therapy performed. The results of helminthoovoscopy are interpreted in the context of clinical data. There was a significant increase in the count of HLA DR monocytes and in the level of IgA and a reduction in IgE and IL-4 with a substantial rise in the cellular production of other cytokines.