RESUMO
Pharmacodynamics of vecuronium have been studied in children 1 to 10 years old. Doses from 0.015 to 0.1 mg/kg were given and the effects measured mechanically and by electromyography. For 0.1 mg/kg the pharmacokinetics were established. A smaller distribution volume and higher plasma clearance in children as compared to adults have been found, while the dose-effect ratio is the same. The action of vecuronium is shorter in children than in adults.
Assuntos
Bloqueadores Neuromusculares/farmacologia , Fármacos Neuromusculares não Despolarizantes/farmacologia , Pancurônio/análogos & derivados , Fatores Etários , Criança , Pré-Escolar , Eletromiografia , Feminino , Humanos , Lactente , Cinética , Masculino , Microcomputadores , Contração Muscular/efeitos dos fármacos , Miografia , Bloqueadores Neuromusculares/administração & dosagem , Bloqueadores Neuromusculares/metabolismo , Junção Neuromuscular/efeitos dos fármacos , Junção Neuromuscular/fisiologia , Fármacos Neuromusculares não Despolarizantes/administração & dosagem , Fármacos Neuromusculares não Despolarizantes/metabolismo , Pancurônio/administração & dosagem , Pancurônio/metabolismo , Pancurônio/farmacologia , Transmissão Sináptica/efeitos dos fármacos , Brometo de VecurônioRESUMO
A method has been developed for blood-brain barrier disruption to provide reproducible access to the cerebrospinal fluid of the cerebello-medullary cistern. The technique was used successfully to investigate transfer of pancuronium to the cerebral CSF compartment in pigs. After osmotic disruption of the blood-brain barrier, pancuronium concentrations increased significantly in the cerebrospinal fluid.