Pesquisa | Biblioteca Virtual em Saúde

1.

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.

van der Klaauw, Agatha A; Croizier, Sophie; Mendes de Oliveira, Edson; Stadler, Lukas K J; Park, Soyoung; Kong, Youxin; Banton, Matthew C; Tandon, Panna; Hendricks, Audrey E; Keogh, Julia M; Riley, Susanna E; Papadia, Sofia; Henning, Elana; Bounds, Rebecca; Bochukova, Elena G; Mistry, Vanisha; O'Rahilly, Stephen; Simerly, Richard B; Minchin, James E N; Barroso, Inês; Jones, E Yvonne; Bouret, Sebastien G; Farooqi, I Sadaf.

Cell ; 176(4): 729-742.e18, 2019 02 07.

Artigo em Inglês | MEDLINE | ID: mdl-30661757

2.

The hunger genes: pathways to obesity.

van der Klaauw, Agatha A; Farooqi, I Sadaf.

Cell ; 161(1): 119-132, 2015 Mar 26.

Artigo em Inglês | MEDLINE | ID: mdl-25815990

3.

Defining the neural basis of appetite and obesity: from genes to behaviour.

Farooqi, I Sadaf.

Clin Med (Lond) ; 14(3): 286-9, 2014 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-24889574

4.

Monogenic Obesity Syndromes Provide Insights Into the Hypothalamic Regulation of Appetite and Associated Behaviors.

Farooqi, I Sadaf.

Biol Psychiatry ; 91(10): 856-859, 2022 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-35369984

5.

Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum.

Fletcher, Paul C; Napolitano, Antonella; Skeggs, Andrew; Miller, Sam R; Delafont, Bruno; Cambridge, Victoria C; de Wit, Sanne; Nathan, Pradeep J; Brooke, Allison; O'Rahilly, Stephen; Farooqi, I Sadaf; Bullmore, Edward T.

J Neurosci ; 30(43): 14346-55, 2010 Oct 27.

Artigo em Inglês | MEDLINE | ID: mdl-20980590

6.

Monogenic human obesity syndromes.

Farooqi, I Sadaf.

Handb Clin Neurol ; 181: 301-310, 2021.

Artigo em Inglês | MEDLINE | ID: mdl-34238466

7.

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis.

Yang, Yongjie; van der Klaauw, Agatha A; Zhu, Liangru; Cacciottolo, Tessa M; He, Yanlin; Stadler, Lukas K J; Wang, Chunmei; Xu, Pingwen; Saito, Kenji; Hinton, Antentor; Yan, Xiaofeng; Keogh, Julia M; Henning, Elana; Banton, Matthew C; Hendricks, Audrey E; Bochukova, Elena G; Mistry, Vanisha; Lawler, Katherine L; Liao, Lan; Xu, Jianming; O'Rahilly, Stephen; Tong, Qingchun; O'Malley, Bert W; Farooqi, I Sadaf; Xu, Yong.

Nat Commun ; 10(1): 1718, 2019 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-30979869

8.

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for ß-MSH and desacetyl α-MSH in energy homeostasis.

Kirwan, Peter; Kay, Richard G; Brouwers, Bas; Herranz-Pérez, Vicente; Jura, Magdalena; Larraufie, Pierre; Jerber, Julie; Pembroke, Jason; Bartels, Theresa; White, Anne; Gribble, Fiona M; Reimann, Frank; Farooqi, I Sadaf; O'Rahilly, Stephen; Merkle, Florian T.

Mol Metab ; 17: 82-97, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30201275

9.

A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome.

Bochukova, Elena G; Lawler, Katherine; Croizier, Sophie; Keogh, Julia M; Patel, Nisha; Strohbehn, Garth; Lo, Kitty K; Humphrey, Jack; Hokken-Koelega, Anita; Damen, Layla; Donze, Stephany; Bouret, Sebastien G; Plagnol, Vincent; Farooqi, I Sadaf.

Cell Rep ; 22(13): 3401-3408, 2018 03 27.

Artigo em Inglês | MEDLINE | ID: mdl-29590610

10.

Oxytocin administration suppresses hypothalamic activation in response to visual food cues.

van der Klaauw, Agatha A; Ziauddeen, Hisham; Keogh, Julia M; Henning, Elana; Dachi, Sekesai; Fletcher, Paul C; Farooqi, I Sadaf.

Sci Rep ; 7(1): 4266, 2017 06 27.

Artigo em Inglês | MEDLINE | ID: mdl-28655900

11.

Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety.

Moir, Lee; Bochukova, Elena G; Dumbell, Rebecca; Banks, Gareth; Bains, Rasneer S; Nolan, Patrick M; Scudamore, Cheryl; Simon, Michelle; Watson, Kimberly A; Keogh, Julia; Henning, Elana; Hendricks, Audrey; O'Rahilly, Stephen; Barroso, Inês; Sullivan, Adrienne E; Bersten, David C; Whitelaw, Murray L; Kirsch, Susan; Bentley, Elizabeth; Farooqi, I Sadaf; Cox, Roger D.

Mol Metab ; 6(11): 1419-1428, 2017 11.

Artigo em Inglês | MEDLINE | ID: mdl-29107289

12.

Melanocortin receptors weigh in.

O'Rahilly, Stephen; Yeo, Giles S H; Farooqi, I Sadaf.

Nat Med ; 10(4): 351-2, 2004 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-15057231

13.

Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor.

Bhattacharyya, Sumit; Luan, Jian'an; Farooqi, I Sadaf; Keogh, Julia; Montague, Carl; Brennand, John; Jorde, Lynn; Wareham, Nicholas J; O'Rahilly, Stephen.

J Endocrinol ; 183(1): 115-20, 2004 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-15525579

14.

EJE Prize 2012: Obesity: from genes to behaviour.

Farooqi, I Sadaf.

Eur J Endocrinol ; 171(5): R191-5, 2014 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-25127711

15.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken, Thomas; Girard, Christophe A; Tung, Yi-Chun Loraine; Webby, Celia J; Saudek, Vladimir; Hewitson, Kirsty S; Yeo, Giles S H; McDonough, Michael A; Cunliffe, Sharon; McNeill, Luke A; Galvanovskis, Juris; Rorsman, Patrik; Robins, Peter; Prieur, Xavier; Coll, Anthony P; Ma, Marcella; Jovanovic, Zorica; Farooqi, I Sadaf; Sedgwick, Barbara; Barroso, Inês; Lindahl, Tomas; Ponting, Chris P; Ashcroft, Frances M; O'Rahilly, Stephen; Schofield, Christopher J.

Science ; 318(5855): 1469-72, 2007 Nov 30.

Artigo em Inglês | MEDLINE | ID: mdl-17991826

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Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.

The hunger genes: pathways to obesity.

Defining the neural basis of appetite and obesity: from genes to behaviour.

Monogenic Obesity Syndromes Provide Insights Into the Hypothalamic Regulation of Appetite and Associated Behaviors.

Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum.

Monogenic human obesity syndromes.

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis.

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for ß-MSH and desacetyl α-MSH in energy homeostasis.

A Transcriptomic Signature of the Hypothalamic Response to Fasting and BDNF Deficiency in Prader-Willi Syndrome.

Oxytocin administration suppresses hypothalamic activation in response to visual food cues.

Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety.

Melanocortin receptors weigh in.

Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor.

EJE Prize 2012: Obesity: from genes to behaviour.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.