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1.
J Altern Complement Med ; 7(2): 187-93, 2001 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11327524

RESUMO

OBJECTIVES: To see whether Strychnos nux-vomica extract (mother tincture [MT]), its potency Nux 30c, and its principal alkaloid, strychnine, could reduce voluntary ethanol intake in rats. To analyze the solution structure of Nux MT, Nux 30c, 90% ethanol, and ethanol 30c by means of electronic (ES) and nuclear nuclear magnetic resonance (NMR) spectra. DESIGN: Potentially alcoholic rats were first given 20% ethanol and then kept on a two-choice bottle, one with 20% ethanol and another with tap water. These rats were given the following oral treatments for 15 days: group 1, control; group 2, strychnine at 0.36 mg/kg per day; group 3, ethanolic extract of S. nux-vomica seeds (Nux MT) at 3.6 mg/kg per day; and group 4, Nux 30c at 0.05 mL/d per rat. Nux 30c was prepared by successive dilution of Nux MT and 90% ethanol (1:100) and sonication at 20 kHz for 30 seconds in 30 steps. RESULTS: Both Nux MT and Nux 30c significantly reduced ethanol intake and increased water intake in rats. ES of two dilutions of Nux MT and Nux 30c showed intersections at more than one point suggesting existence of molecular complexes. ES of Nux MT in CCl4 showed a red shift when 90% ethanol was added indicating molecular complexation and charge transfer interaction between ethanol and Nux compounds. NMR spectra of Nux MT, 90% ethanol, ethanol 30c, and Nux 30c indicated a change in solution structure of the medium (90% ethanol) of Nux 30c. CONCLUSION: Nux MT and Nux 30c could reduce ethanol intake in rats. The altered solution structure of Nux 30c is thought to mimic Nux MT and produce ethanol aversion in rats.


Assuntos
Dissuasores de Álcool/farmacologia , Comportamento Alimentar/efeitos dos fármacos , Homeopatia , Plantas Medicinais , Estricnina/farmacologia , Dissuasores de Álcool/uso terapêutico , Alcoolismo/prevenção & controle , Animais , Modelos Animais de Doenças , Etanol , Extratos Vegetais/farmacologia , Extratos Vegetais/uso terapêutico , Ratos , Estricnina/uso terapêutico
2.
Homeopathy ; 95(3): 144-7, 2006 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-16815517

RESUMO

Lady's finger plants (Hibiscus esculentus), grown in pots, were inoculated with the second-stage larvae (76+/-6) of root-knot nematodes Meloidogyne incognita, starting 7 days later they were treated with Cina 30c, Santonin 30c or Ethanol 30c by foliar spray for 10 consecutive days. The drugs in 90% ethanol were diluted with distilled water 1:1000 before application on plants. Thirty days after the last treatment the plants were uprooted. Cina 30c and Santonin 30c reduced nematode infestation of plants significantly in terms of root-gall number, root-protein content and nematode population in roots. Santonin 30c reduced root water content. Santonin 30c may have influenced the water channel proteins of root tissues thereby altering the water contents of roots. The reduced water content in roots might have adversely affected the root-knot nematodes and thus reduced nematode infestation. Ethanol 30c also has some effect on treated plants.


Assuntos
Antinematódeos/farmacologia , Hibiscus , Controle Biológico de Vetores/métodos , Doenças das Plantas/parasitologia , Raízes de Plantas/parasitologia , Santonina/farmacologia , Tylenchoidea/fisiologia , Animais , Homeopatia/métodos , Interações Hospedeiro-Parasita , Materia Medica , Meristema , Tylenchoidea/efeitos dos fármacos
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