Pesquisa | Biblioteca Virtual em Saúde

1.

Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance.

van der Klaauw, Agatha A; Croizier, Sophie; Mendes de Oliveira, Edson; Stadler, Lukas K J; Park, Soyoung; Kong, Youxin; Banton, Matthew C; Tandon, Panna; Hendricks, Audrey E; Keogh, Julia M; Riley, Susanna E; Papadia, Sofia; Henning, Elana; Bounds, Rebecca; Bochukova, Elena G; Mistry, Vanisha; O'Rahilly, Stephen; Simerly, Richard B; Minchin, James E N; Barroso, Inês; Jones, E Yvonne; Bouret, Sebastien G; Farooqi, I Sadaf.

Cell ; 176(4): 729-742.e18, 2019 02 07.

Artigo em Inglês | MEDLINE | ID: mdl-30661757

2.

Distinct modulatory effects of satiety and sibutramine on brain responses to food images in humans: a double dissociation across hypothalamus, amygdala, and ventral striatum.

Fletcher, Paul C; Napolitano, Antonella; Skeggs, Andrew; Miller, Sam R; Delafont, Bruno; Cambridge, Victoria C; de Wit, Sanne; Nathan, Pradeep J; Brooke, Allison; O'Rahilly, Stephen; Farooqi, I Sadaf; Bullmore, Edward T.

J Neurosci ; 30(43): 14346-55, 2010 Oct 27.

Artigo em Inglês | MEDLINE | ID: mdl-20980590

3.

Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis.

Yang, Yongjie; van der Klaauw, Agatha A; Zhu, Liangru; Cacciottolo, Tessa M; He, Yanlin; Stadler, Lukas K J; Wang, Chunmei; Xu, Pingwen; Saito, Kenji; Hinton, Antentor; Yan, Xiaofeng; Keogh, Julia M; Henning, Elana; Banton, Matthew C; Hendricks, Audrey E; Bochukova, Elena G; Mistry, Vanisha; Lawler, Katherine L; Liao, Lan; Xu, Jianming; O'Rahilly, Stephen; Tong, Qingchun; O'Malley, Bert W; Farooqi, I Sadaf; Xu, Yong.

Nat Commun ; 10(1): 1718, 2019 04 12.

Artigo em Inglês | MEDLINE | ID: mdl-30979869

4.

Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome.

Polex-Wolf, Joseph; Lam, Brian Yh; Larder, Rachel; Tadross, John; Rimmington, Debra; Bosch, Fàtima; Cenzano, Verónica Jiménez; Ayuso, Eduard; Ma, Marcella Kl; Rainbow, Kara; Coll, Anthony P; O'Rahilly, Stephen; Yeo, Giles Sh.

J Clin Invest ; 128(3): 960-969, 2018 03 01.

Artigo em Inglês | MEDLINE | ID: mdl-29376887

5.

Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for ß-MSH and desacetyl α-MSH in energy homeostasis.

Kirwan, Peter; Kay, Richard G; Brouwers, Bas; Herranz-Pérez, Vicente; Jura, Magdalena; Larraufie, Pierre; Jerber, Julie; Pembroke, Jason; Bartels, Theresa; White, Anne; Gribble, Fiona M; Reimann, Frank; Farooqi, I Sadaf; O'Rahilly, Stephen; Merkle, Florian T.

Mol Metab ; 17: 82-97, 2018 11.

Artigo em Inglês | MEDLINE | ID: mdl-30201275

6.

Disruption of the homeodomain transcription factor orthopedia homeobox (Otp) is associated with obesity and anxiety.

Moir, Lee; Bochukova, Elena G; Dumbell, Rebecca; Banks, Gareth; Bains, Rasneer S; Nolan, Patrick M; Scudamore, Cheryl; Simon, Michelle; Watson, Kimberly A; Keogh, Julia; Henning, Elana; Hendricks, Audrey; O'Rahilly, Stephen; Barroso, Inês; Sullivan, Adrienne E; Bersten, David C; Whitelaw, Murray L; Kirsch, Susan; Bentley, Elizabeth; Farooqi, I Sadaf; Cox, Roger D.

Mol Metab ; 6(11): 1419-1428, 2017 11.

Artigo em Inglês | MEDLINE | ID: mdl-29107289

7.

Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing.

Lam, Brian Y H; Cimino, Irene; Polex-Wolf, Joseph; Nicole Kohnke, Sara; Rimmington, Debra; Iyemere, Valentine; Heeley, Nicholas; Cossetti, Chiara; Schulte, Reiner; Saraiva, Luis R; Logan, Darren W; Blouet, Clemence; O'Rahilly, Stephen; Coll, Anthony P; Yeo, Giles S H.

Mol Metab ; 6(5): 383-392, 2017 05.

Artigo em Inglês | MEDLINE | ID: mdl-28462073

8.

Melanocortin receptors weigh in.

O'Rahilly, Stephen; Yeo, Giles S H; Farooqi, I Sadaf.

Nat Med ; 10(4): 351-2, 2004 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-15057231

9.

Studies of the neuromedin U-2 receptor gene in human obesity: evidence for the existence of two ancestral forms of the receptor.

Bhattacharyya, Sumit; Luan, Jian'an; Farooqi, I Sadaf; Keogh, Julia; Montague, Carl; Brennand, John; Jorde, Lynn; Wareham, Nicholas J; O'Rahilly, Stephen.

J Endocrinol ; 183(1): 115-20, 2004 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-15525579

10.

Loss of agouti-related peptide does not significantly impact the phenotype of murine POMC deficiency.

Corander, Marcus P; Rimmington, Debra; Challis, Benjamin G; O'Rahilly, Stephen; Coll, Anthony P.

Endocrinology ; 152(5): 1819-28, 2011 May.

Artigo em Inglês | MEDLINE | ID: mdl-21363936

11.

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

Tung, Yi-Chun Loraine; Ayuso, Eduard; Shan, Xiaoye; Bosch, Fatima; O'Rahilly, Stephen; Coll, Anthony P; Yeo, Giles S H.

PLoS One ; 5(1): e8771, 2010 Jan 19.

Artigo em Inglês | MEDLINE | ID: mdl-20098739

12.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken, Thomas; Girard, Christophe A; Tung, Yi-Chun Loraine; Webby, Celia J; Saudek, Vladimir; Hewitson, Kirsty S; Yeo, Giles S H; McDonough, Michael A; Cunliffe, Sharon; McNeill, Luke A; Galvanovskis, Juris; Rorsman, Patrik; Robins, Peter; Prieur, Xavier; Coll, Anthony P; Ma, Marcella; Jovanovic, Zorica; Farooqi, I Sadaf; Sedgwick, Barbara; Barroso, Inês; Lindahl, Tomas; Ponting, Chris P; Ashcroft, Frances M; O'Rahilly, Stephen; Schofield, Christopher J.

Science ; 318(5855): 1469-72, 2007 Nov 30.

Artigo em Inglês | MEDLINE | ID: mdl-17991826

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