RESUMO
BACKGROUND: Homeopathy is based on the principle of similitude (similia similibus curentur) using medicines that cause effects similar to the symptoms of disease in order to stimulate the reaction of the organism. Such vital, homeostatic or paradoxical reaction of the organism is closely related to rebound effect of drugs. METHOD: Review of the literature concerning the rebound effects of drugs used to suppress gastric acidity, particularly proton pump inhibitors (PPIs). RESULTS: The mechanism of action of these effects is discussed. Rebound in terms of clinical symptoms and physiological effects occur in about 40% of people taking PPIs, their timing depends on the half-life of the drug and the adaptation period of the physiological mechanisms involved. The wide use of PPIs may be linked to the rising incidence of carcinoid tumours. CONCLUSIONS: These findings support Hahnemann's concept of secondary action of drugs. We are developing a homeopathic materia medica and repertory of modern drugs on the basis of reported rebound effects.
Assuntos
Medicina Baseada em Evidências , Refluxo Gastroesofágico/prevenção & controle , Homeopatia/métodos , Materia Medica/uso terapêutico , Inibidores da Bomba de Prótons/efeitos adversos , Síndrome de Abstinência a Substâncias/prevenção & controle , Relação Dose-Resposta a Droga , Ácido Gástrico/metabolismo , Refluxo Gastroesofágico/tratamento farmacológico , Humanos , Inibidores da Bomba de Prótons/administração & dosagem , Síndrome de Abstinência a Substâncias/etiologiaRESUMO
In order to investigate the mechanism of Centipede on the function of animal gastrointestinal digestion, we studied the effects of cetipede aqueous extract on animal digestion, secretion and intestional movement. The results showed that the Centipede extract increased the volume of gastric juice and acid, activity of pepsin, volume of pancreatic juice and protein in rat. The Centipede extract also accelerated the mice intestinal movement. The above results revevaled that Centipede could regulate the function of the gastrointestinal digestion, secretion and movement.