RESUMO
A capillary electrophoresis-tandem mass spectrometry (CE-MS/MS) method for amphetamine (AM), phentermine (PTM), methamphetamine (MAM), methylenedioxyamphetamine (MDA), methylenedioxymethamphetamine (MDMA), and methylenedioxyethylamphetamine (MDEA) in commercial samples of homeopathic and phytotherapic medicines and dietary supplements is presented. The samples were submitted to a modified QuEChERS extraction procedure (at apparent pH 13) followed by electrophoretic separation in 0.1molL-1 formic acid electrolyte (pH 2.4) and detection by ESI-MS/MS. A polyvinyl alcohol coated capillary was employed to prevent the adsorption of the analytes to the capillary wall. The limits of detection and quantitation were from 0.02 to 0.06µgL-1 and from 0.06 to 0.21µgL-1, respectively, with recovery ranging from 85 to 123% and the standard deviations were not greater than 6.1%. In addition, the separation occurs in less than six minutes.
Assuntos
Anfetamina/análise , Fármacos Antiobesidade/análise , Produtos Biológicos/análise , Estimulantes do Sistema Nervoso Central/análise , Suplementos Nutricionais/análise , Eletroforese Capilar/métodos , Espectrometria de Massas em Tandem/métodos , Limite de Detecção , Espectrometria de Massas por Ionização por Electrospray/métodosRESUMO
The Laboratory of the Government Chemist examines most of the drugs that have been seized at the point of entry into the United Kingdom of Great Britain and Northern Ireland and has developed analytical methods for their rapid identification in the field and for more exact analysis and quantitation in the Laboratory. These methods are described for the major types of drugs encountered. Many seizures are examined in greater detail in order to compare samples and to correlate origin with physical and chemical appearance. Information on the procedures necessary to undertake this aspect of work is also presented.