RESUMO
Aerodynamic thermal breakup droplet ionization (ATBDI) in mass spectrometric drug analysis is considered. Cocaine, heroin, and the main alkaloids of opium (morphine, codeine, papaverine) were chosen as the test compounds. The principles of ATBDI ionization are discussed. The dependences of the intensities of the peaks of the target compounds on temperature during ATBDI ionization are also considered. In some cases, a comparison of ATBDI ionization with electrospray ionization (ESI) was performed. In addition, a comparison of methods is demonstrated by the analysis of confiscated opium that was provided by the local police department. Five major alkaloids are found in opium: morphine, codeine, thebaine, papaverine, and narcotine.
Assuntos
Cocaína/análise , Heroína/análise , Espectrometria de Massas/métodos , Entorpecentes/análise , Alcaloides Opiáceos/análise , Aerossóis , Codeína/análise , Temperatura Alta , Ópio/análise , Papaverina/análise , Soluções/química , Espectrometria de Massas por Ionização por ElectrosprayRESUMO
The application of micellar electrokinetic capillary chromatography (MECC) to the analysis of illicit drug seizures is presented. Areas investigated include general screening and qualitative and, in some instances, quantitative analysis of various drugs, including heroin, opium, cocaine, amphetamines, LSD and anabolic steroids. Due to its high efficiency, high selectivity and general applicability, MECC is well suited for forensic drug analyses.
Assuntos
Eletroforese Capilar/métodos , Drogas Ilícitas/análise , Micelas , Detecção do Abuso de Substâncias/métodos , Anfetaminas/análise , Anabolizantes/análise , Cocaína/análise , Medicina Legal/métodos , Heroína/análise , Dietilamida do Ácido Lisérgico/análise , Ópio/análiseRESUMO
This paper reviews the applications of high-pressure liquid chromatography (HPLC) to forensic problems, and discusses some of the developments that have taken place in the use of the technique in the Metropolitan Police Laboratory. Preparation of octadecyltrichlorosilane-modified silica is described and some of the chromatographic characteristics of this material are investigated. Applications of HPLC to the analysis of cannabis, opium alkaloids, amphetamine-related materials, LSD and polynuclear hydrocarbons are described.
Assuntos
Cromatografia Líquida de Alta Pressão , Medicina Legal , Alcaloides/análise , Anfetaminas/análise , Benzazepinas/análise , Cannabis/análise , Cocaína/análise , Heroína/análise , Dietilamida do Ácido Lisérgico/análise , Ópio/análise , Ácidos Ftálicos/análise , Compostos Policíclicos/análise , Dióxido de Silício , Solventes , Oligoelementos/análiseRESUMO
The Laboratory of the Government Chemist examines most of the drugs that have been seized at the point of entry into the United Kingdom of Great Britain and Northern Ireland and has developed analytical methods for their rapid identification in the field and for more exact analysis and quantitation in the Laboratory. These methods are described for the major types of drugs encountered. Many seizures are examined in greater detail in order to compare samples and to correlate origin with physical and chemical appearance. Information on the procedures necessary to undertake this aspect of work is also presented.