[Clinical study on combined treatment of shuizhi tuyuan powder and nifedipine in treating hypertension patients complicated with left ventricular hypertrophy].

Patients with essential hypertension complicated with left ventricular hypertrophy (LVH) confirmed by ultrasonic cardiography were divided randomly into observation group and control group. Both groups were treated with nifedipine. Shuizhi Tuyuan Powder (SZTYP, consisted of Hirudo nipponia and Eupolyphaga sinensis) was given in addition to the observation group. The therapeutic course for the two groups were 6 months. Results showed that after one course of treatment, the myocardial weight index lowered from 136.8 +/- 7.5 g/m2 to 130.5 +/- 6.4 g/m2 in observation group, while in control group, it lowered from 136.7 +/- 7.4 g/m2 to 134.3 +/- 6.2 g/m2, the difference between the two groups was significant (P < 0.01). The symptoms were relieved in part of the patients with early stage of cerebrovascular disease treated with SZTYP. The results suggested that SZTYP combined with nifedipine has active curative effect on essential hypertension patients complicated by LVH and part patients in early stage of cerebrovascular disease.

Potentiation of pancuronium induced neuromuscular blockade by calcium channel blockers in vitro.

The calcium channel blockers verapamil, methoxyverapamil, diltiazem, and nisoldipine have been tested for interactions with the nondepolarizing muscle relaxant pancuronium bromide by using the indirectly stimulated in vitro preparation of the rat hemidiaphragm. Dose response curves of each calcium channel blocker, pancuronium bromide, and combinations of both were determined. Each of the four calcium channel blocking drugs showed agonistic interaction in potentiating pancuronium induced neuromuscular blockade.

El efecto hemodinámico de la combinación propranolol y nifedipina en la paciente sometido a revascularización coronaria / Haemodinamyc effect with propranol-nifedipine treatment in the patient undergoing coronary bypass surgery

Se estudiaron 24 pacientes programados para revascularización coronaria. La técnica anestésica empleada fue Fentanil-Enflurano-Oxígeno-Pancuronio. Se comparó el comportamiento hemodinámico durante el período previo a la circulación extracorpórea en un grupo de pacientes bajo tratamiento con dinitrato de isosorbide y propranolol, un grupo bajo tratamiento con nifedipina y propranolol y un grupo control únicamente con dinitrato de isosorbide. La escasa literatura existente sugiere que la suspensión de la nifedipina antes de la cirugía disminuye la necesidad de emplear inotrópicos. El continuar con ella se ha asociado a un aumento en los requerimientos de vasodilatadores. En nuestro estudio no encontramos diferencia significativa entre ninguno de los 3 grupos estudiados. La literatura existente y los resultados obtenidos sugieren que no existe razón para suspender la nifedipina antes de la cirugía.