Reported case of a pacient with chronic urticaria and angioedema of more than 18 years of evolution. Poor control of symptoms with allopathic treatment and frequent visits to the emergency room deteriorated her quality of life and brought insecurity due to the potencial severity of the condition. In her first homeopathic appointment was verified high degree of symptomatic similarity to the pathogenesis of Apis mellifica, which was introduced and modified the patients lifehistory, with excellent control of the condition. Performed literaturereview on urticaria and the policresto Apis mellifica that has been studied in vitro in search for evidence that might explain the effects of Homeopathy. (AU)