Effects of neostigmine, edrophonium, 4-aminopyridine and their combinations.
Acta Anaesthesiol Belg
; 39(1): 55-8, 1988.
Article
in En
| MEDLINE
| ID: mdl-2835880
ABSTRACT
A study was carried out in the in-vitro rat phrenic nerve hemidiaphragm preparation to find a fast and strong working antagonist of non-depolarizing muscle relaxants. We studied neostigmine, edrophonium, 4-aminopyridine and their combinations from the cumulative concentration response curves of pancuronium. Neostigmine, edrophonium and 4-aminopyridine all antagonized the effect of pancuronium. Neostigmine and 4-aminopyridine did potentiate each other as did neostigmine and edrophonium. The combination of edrophonium and 4-aminopyridine showed less total effect than the addition of their individual effect. We conclude that the mechanisms of action of neostigmine and edrophonium are different.
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Database:
MEDLINE
Main subject:
Edrophonium
/
Aminopyridines
/
Neostigmine
Limits:
Animals
Language:
En
Journal:
Acta Anaesthesiol Belg
Year:
1988
Type:
Article