Prostatitis' chronic pelvic painsyndrome is a prevalent condition among men, bringing much suffering and social disability. The conventional therapeutic approach has little effectiveness and many side effects. It is reported a clinical case of the mentioned syndrome where was used the individualized homeopathic management and administered Colocynthis remedy. There was an excellent therapeutic response with complete resolution of symptoms along the follow up period. Presently, Homeophathy has emerged as an useful and promising tool in this painsyndrome's treatment.(AU)