1.
J Med Chem
; 26(12): 1778-80, 1983 Dec.
Article
in English
| MEDLINE
| ID: mdl-6227748
ABSTRACT
Etodolac, 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid, a clinically effective analgesic and antiinflammatory agent, has been resolved via a chromatographic separation of its diastereoisomeric esters with (-)-borneol. The effects of the enantiomers were studied in vitro on prostaglandin synthetase and on adjuvant-induced arthritis in rats. The biochemical and pharmacological results show that virtually all of the effects of etodolac are due to the (+) enantiomer.
Subject(s)
Acetates/isolation & purification , Anti-Inflammatory Agents/therapeutic use , Cyclooxygenase Inhibitors , Acetates/therapeutic use , Animals , Arthritis, Experimental/drug therapy , Chromatography, High Pressure Liquid , Etodolac , Male , Rats , Rats, Inbred Strains , Stereoisomerism
2.
Prostaglandins
; 11(6): 981-6, 1976 Jun.
Article
in English
| MEDLINE
| ID: mdl-7000
3.
Curr Top Mol Endocrinol
; 3: 373-8, 1976.
Article
in English
| MEDLINE
| ID: mdl-1052675