ABSTRACT
Anaerobic clostridial infection is the most severe form of paraproctitis. The incubation period is very short, from 3 to 6 hours, sometimes lasting for 1-2 days. Clostridial infection spreads rapidly and induces gas gangrene, causes destruction of cells and other intermediate substances, and impedes blood circulation. This paper presents a case study of an extremely severe form of anaerobic infection with spontaneous gas gangrene, cellulitis, fasciomyositic necrosis, severe intoxication and septic shock on the abdominal front and lateral surfaces. This patient presented as infected with Clostridium septicum, a rare and highly toxic Gram-positive, spore-forming, obligate anaerobic bacillus that progresses and migrates rapidly, affecting all soft tissues (muscle, fascia), and produces four toxins which cause gas gangrene, intravascular hemolysis, tissue necrosis, and septic shock. The mortality rate is typically 80%. In this case study, a positive clinical outcome was achieved by aggressive identification of the microbe, appropriate and immediate therapy, and vigorous surgical intervention. Specifically, immediate surgery was conducted to ensure a wide excision of damaged tissues, necrectomy, curettage, wide drainage, readjustment, oxygenation through drainages, further additional surgical corrections through CT control with wide bandages in the operating area. Further, the diagnostic workup was thorough, identifying the microbe through a properly constructed diagnostic algorithm, ultrasound and CT studies, infectious agent assessments, and bacteriological monitoring carried out on the 1st-2nd-5th-7th-12th-15th-21st-25th days. Rational antibiotic therapy with permanent susceptibility testing informed the selection of an appropriate agent. Finally, markers for the evaluation of severity (Apache scale) were assessed, as they were for stage of infection (prokalcitonin), inflammation (CRP) and other indicators.
Subject(s)
Clostridium Infections/diagnosis , Fasciitis, Necrotizing/diagnosis , Gas Gangrene/diagnosis , Myositis/diagnosis , Proctitis/diagnosis , Abdominal Wall , Adult , Clostridium Infections/complications , Clostridium Infections/microbiology , Clostridium septicum/isolation & purification , Fasciitis, Necrotizing/complications , Gas Gangrene/etiology , Humans , Male , Myositis/complications , Proctitis/complications , Proctitis/microbiologyABSTRACT
UNLABELLED: Primary hypophosphatemic rickets is a rare disorder caused by inborn defect of renal tubular reabsorbtion and usually manifested in childhood and infancy with stunted growth and deformities of lower limbs. Patient 12 years old, female, was born to healthy parents, at 41 weeks of gestation by normal delivery and had a normal birth weight and length. She had one healthy sibling (male). Psychomotor development until the age of 2 years was normal. Since the age of 2 years deformation of legs and difficulties with walking have been observed. The Patient was consulted by Pediatric Orthopedist, Nephrologists and Endocrinologist. The blood biochemical findings revealed normal pH, normal calcium (CA), potassium (K), sodium (Na) concentrations, very low phosphate (P) with markedly elevated alkaline phosphatase (AP) and slightly elevated parathyroid hormone (PTH) concentration; urine test indicated impaired tubular function: mild glucosuria, proteinuria, and markedly increased phosphaturia. Phosphate tubular reabsorbtion (PTR) was 52%, phosphate/creatinine clearance 0,52, renal threshold phosphate concentration (TmP/GFR) 0,25 mmol/l. Genetic tests results not available yet. RESULTS: the diagnosis of phosphate diabetes made on the basis of clinical-laboratory data. The therapy with Inorganic phosphate (50-100mg/kg/d) and 1,25(OH)D3 40-50 ng/kg/d had been started. Childs walking abilities improved with treatment, the deformation of legs decreased, but O-legs and other skeletal deformations are still remarkable. Auxological parameters are not satisfactory. Physical growth is below the normal range (height SDS -3,78); the patient's predicted height less than target height. Biochemical monitoring performed regularly under the treatment, serum phosphate remains below normal, serum ALP is still elevated. CONCLUSION: This case is in line with other publications and indicates the difficulty to achieve normal phosphate levels and normal growth without an additional treatment with growth hormone. At this stage of the disease, the question of referring to the growth hormone therapy is being considered aimed to improve the growth tendencies. It is possible that orthopedic surgery is also needed in the future.
Subject(s)
Familial Hypophosphatemic Rickets/diagnosis , Alkaline Phosphatase/blood , Calcium/blood , Child , Familial Hypophosphatemic Rickets/diagnostic imaging , Familial Hypophosphatemic Rickets/drug therapy , Female , Humans , Parathyroid Hormone/blood , Phosphates/blood , Phosphates/therapeutic use , Phosphates/urine , RadiographyABSTRACT
Experiments were conducted on 48 dogs to study the terms and degree of resolution of various plastic materials--areas of fascia lata of the animal's thigh, as well as explants (medical glue compositions, biological absorbable lavsan-armored Soviet medical films) in the pararectal tissues and in artificial formation of rectal fistulas. It is shown that auto- and explantation may be performed in the treatment of rectal fistulas in patients. The suggested method was applied in the clinic in 136 operations for complex trans- and extrasphincteric pararectal fistulas. The results were followed-up for 12 months to 5 years and proved to be good in 126 patients.
Subject(s)
Rectal Fistula/surgery , Animals , Disease Models, Animal , Dogs , Fascia Lata/transplantation , Female , Follow-Up Studies , Humans , Male , Polyethylene Terephthalates , Postoperative Complications/epidemiology , Rectal Fistula/epidemiology , Rectal Fistula/pathology , Rectum/pathology , Rectum/surgery , Recurrence , Surgical Mesh , Transplantation, AutologousABSTRACT
New methods of operations for high extrasphincter fistulas of the rectum have been developed consisting in dissection of the sphincter passage from the side of perineum to its inner opening and closure of the opening from the side of the intestinal lumen with a flap of wide femoral fascia or bioelastic material with the help of medical glue MK-7.