ABSTRACT
An orally administered bilayer tablet with Tamsulosin (TAM) as the sustained release (SR) and Finasteride (FIN) as immediate release (IR) was manufactured. A response surface methodology was employed to formulate bilayer tablets with individual release layers, i.e., sustained and immediate release (SR and IR). Independent variables selected in both cases comprise hydroxypropyl methylcellulose (HPMC) as SR polymer, and avicel PH102 in the inner layer while Triacetin and talc in the outer layer, respectively. Tablets were prepared by direct compression, a total of 11 formulations were prepared for inner layer TAM, and 9 formulations for outer layer FIN were designed; these formulations were evaluated for hardness, friability, thickness, %drug content, and %drug release. A central composite design was employed in response surface methodology to design and optimize the formulation. The percentage of drug released was evaluated by in-vitro USP dissolution method of optimized formulation for 0.5, 2, and 6 hrs, and results were 24.63, 52.96, and 97.68 %, respectively. Drug release data was plotted in various kinetic models using a D.D solver, where drug release was first order that is concentration dependent and was best explained by Korsmeyer-Peppa kinetics, as the highest linearity was observed (R2 = 0.9693). However, a very close relationship was also noted with Higuchi kinetics (R2 = 0.9358). The mechanism of drug release was determined through the Korsmeyer model, and exponent "n" was found to be 0.4, indicative of an anomalous diffusion mechanism or diffusion coupled with erosion.
ABSTRACT
BACKGROUND: Emulgels are the emerging drug delivery system nowadays that has become popular for the delivery of hydrophobic drugs. This formulation is considered a novel type of drug delivery system and a mixture of emulsion and gel. OBJECTIVE: The objective of this review is to throw light on the preparation of emulgels and their evaluation which will conclude how important these dosage forms are. In the coming years, it will be most commonly used because it is easy to use and enhances patient compliance. CONCLUSION: Emulgels are easily removable, spreadable, thixotropic, greaseless, have a pleasing appearance, emollient, long shelf life, and transparent. In the present era, the emulgels are being used for the delivery of many drugs like analgesics, anti-inflammatory, anti-acne and anti-fungal. Hence, it is of great pharmacological importance and is relatively free of side effects.