Search details
1.
Rational design and eco-friendly one-pot multicomponent synthesis of novel ethylidenehydrazineylthiazol-4(5H)-ones as potential apoptotic inducers targeting wild and mutant EGFR-TK in triple negative breast cancer.
Bioorg Chem
; 142: 106936, 2024 01.
Article
in English
| MEDLINE | ID: mdl-37890211
2.
Multi-target rational design and synthesis of novel diphenyl-tethered pyrazolopyrimidines targeting EGFR and topoisomerase II with potential DNA intercalation and apoptosis induction.
Bioorg Chem
; 145: 107223, 2024 Apr.
Article
in English
| MEDLINE | ID: mdl-38387399
3.
Rationale design of novel substituted 1,3,5-triazine candidates as dual IDH1(R132H)/ IDH2(R140Q) inhibitors with high selectivity against acute myeloid leukemia: In vitro and in vivo preclinical investigations.
Bioorg Chem
; 149: 107483, 2024 May 21.
Article
in English
| MEDLINE | ID: mdl-38805913
4.
Rational design, synthesis, biological evaluation, and molecular modeling of novel naphthamide derivatives possessing potent, reversible, and competitive inhibitory mode of action over human monoamine oxidase.
Mol Divers
; 2024 May 10.
Article
in English
| MEDLINE | ID: mdl-38727994
5.
Investigating the Promising Anticancer Activity of Cetuximab and Fenbendazole Combination as Dual CBS and VEGFR-2 Inhibitors and Endowed with Apoptotic Potential.
Chem Biodivers
; 21(4): e202302081, 2024 Apr.
Article
in English
| MEDLINE | ID: mdl-38318954
6.
Symbiotic Antidiabetic Effect of Lactobacillus casei and the Bioactive Extract of Cleome droserifolia (Forssk.) Del. on Mice with Type 2 Diabetes Induced by Alloxan.
Chem Biodivers
; 21(1): e202301397, 2024 Jan.
Article
in English
| MEDLINE | ID: mdl-38078801
7.
LC-HRMS Profiling and Cytotoxic Potential of Actinomycetes Associated with the Red Sea Soft Coral Sarcophyton glaucum: In vitro and In silico Studies.
Chem Biodivers
; 21(3): e202301617, 2024 Mar.
Article
in English
| MEDLINE | ID: mdl-38193652
8.
Design and synthesis of novel tetrabromophthalimide derivatives as potential tubulin inhibitors endowed with apoptotic induction for cancer treatment.
Drug Dev Res
; 85(4): e22197, 2024 Jun.
Article
in English
| MEDLINE | ID: mdl-38751223
9.
LC/MS-Based Metabolomics Reveals Chemical Variations of Two Broccoli Varieties in Relation to Their Anticholinesterase Activity: In vitro and In silico Studies.
Plant Foods Hum Nutr
; 2024 Apr 12.
Article
in English
| MEDLINE | ID: mdl-38607508
10.
Promising Cytotoxic butenolides from the Soybean endophytic fungus Aspergillus terreus: a combined molecular docking and in-vitro studies.
J Appl Microbiol
; 134(7)2023 Jul 04.
Article
in English
| MEDLINE | ID: mdl-37401132
11.
Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers.
J Enzyme Inhib Med Chem
; 38(1): 2242714, 2023 Aug 17.
Article
in English
| MEDLINE | ID: mdl-37592917
12.
Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors.
J Enzyme Inhib Med Chem
; 38(1): 176-191, 2023 Dec.
Article
in English
| MEDLINE | ID: mdl-36317648
13.
Design and synthesis of novel rigid dibenzo[b,f]azepines through ring closure technique as promising anticancer candidates against leukaemia and acting as selective topoisomerase II inhibitors and DNA intercalators.
J Enzyme Inhib Med Chem
; 38(1): 2157825, 2023 Dec.
Article
in English
| MEDLINE | ID: mdl-36629421
14.
Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2',3':4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity.
J Enzyme Inhib Med Chem
; 38(1): 2205043, 2023 Dec.
Article
in English
| MEDLINE | ID: mdl-37165800
15.
Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies.
J Enzyme Inhib Med Chem
; 38(1): 2171029, 2023 Dec.
Article
in English
| MEDLINE | ID: mdl-36701269
16.
Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines.
J Enzyme Inhib Med Chem
; 38(1): 2202358, 2023 Dec.
Article
in English
| MEDLINE | ID: mdl-37096560
17.
Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies.
J Enzyme Inhib Med Chem
; 38(1): 2202357, 2023 Dec.
Article
in English
| MEDLINE | ID: mdl-37092260
18.
A Comparative GC/MS Analysis of Citrus Essential Oils: Unveiling the Potential Benefits of Herb-Drug Interactions in Preventing Paracetamol-Induced Hepatotoxicity.
Chem Biodivers
; 20(9): e202300778, 2023 Sep.
Article
in English
| MEDLINE | ID: mdl-37599265
19.
Design, synthesis, and biological evaluation of thienopyrimidine derivatives as multifunctional agents against Alzheimer's disease.
Drug Dev Res
; 84(5): 937-961, 2023 08.
Article
in English
| MEDLINE | ID: mdl-37067008
20.
Fibrosis: Types, Effects, Markers, Mechanisms for Disease Progression, and Its Relation with Oxidative Stress, Immunity, and Inflammation.
Int J Mol Sci
; 24(4)2023 Feb 16.
Article
in English
| MEDLINE | ID: mdl-36835428