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1.

Mycobacterial toxin induces analgesia in buruli ulcer by targeting the angiotensin pathways.

Marion, Estelle; Song, Ok-Ryul; Christophe, Thierry; Babonneau, Jérémie; Fenistein, Denis; Eyer, Joël; Letournel, Frank; Henrion, Daniel; Clere, Nicolas; Paille, Vincent; Guérineau, Nathalie C; Saint André, Jean-Paul; Gersbach, Philipp; Altmann, Karl-Heinz; Stinear, Timothy Paul; Comoglio, Yannick; Sandoz, Guillaume; Preisser, Laurence; Delneste, Yves; Yeramian, Edouard; Marsollier, Laurent; Brodin, Priscille.

Cell ; 157(7): 1565-76, 2014 Jun 19.

Article in English | MEDLINE | ID: mdl-24949969

2.

Experimental and Theoretical Studies on the Reactions of Aliphatic Imines with Isocyanates.

Cotter, Etienne; Pultar, Felix; Riniker, Sereina; Altmann, Karl-Heinz.

Chemistry ; 30(14): e202304272, 2024 Mar 07.

Article in English | MEDLINE | ID: mdl-38226702

3.

Total Synthesis of Isoxeniolide A.

Betschart, Leo; Altmann, Karl-Heinz.

Angew Chem Int Ed Engl ; 63(9): e202315423, 2024 Feb 26.

Article in English | MEDLINE | ID: mdl-38118052

4.

Synthesis and Structure-Activity Relationship Studies of C(13)-Desmethylene-(-)-Zampanolide Analogs.

Brütsch, Tobias M; Cotter, Etienne; Lucena-Agell, Daniel; Redondo-Horcajo, Mariano; Davies, Carolina; Pfeiffer, Bernhard; Pagani, Sandro; Berardozzi, Simone; Fernando Díaz, J; Miller, John H; Altmann, Karl-Heinz.

Chemistry ; 29(36): e202300703, 2023 Jun 27.

Article in English | MEDLINE | ID: mdl-37057902

5.

An Antigen Capture Assay for the Detection of Mycolactone, the Polyketide Toxin of Mycobacterium ulcerans.

Warryn, Louisa; Dangy, Jean-Pierre; Gersbach, Philipp; Gehringer, Matthias; Altmann, Karl-Heinz; Pluschke, Gerd.

J Immunol ; 206(11): 2753-2762, 2021 06 01.

Article in English | MEDLINE | ID: mdl-34031146

6.

Synthesis and Biological Evaluation of C(13)/C(13')-Bis(desmethyl)disorazoleâZ.

Bold, Christian Paul; Lucena-Agell, Daniel; Oliva, María Ángela; Díaz, José Fernando; Altmann, Karl-Heinz.

Angew Chem Int Ed Engl ; 62(5): e202212190, 2023 01 26.

Article in English | MEDLINE | ID: mdl-36281761

7.

Maytansinol Derivatives: Side Reactions as a Chance for New Tubulin Binders.

Marzullo, Paola; Boiarska, Zlata; Pérez-Peña, Helena; Abel, Anne-Catherine; Álvarez-Bernad, Beatriz; Lucena-Agell, Daniel; Vasile, Francesca; Sironi, Maurizio; Altmann, Karl-Heinz; Prota, Andrea E; Díaz, J Fernando; Pieraccini, Stefano; Passarella, Daniele.

Chemistry ; 28(2): e202103520, 2022 Jan 10.

Article in English | MEDLINE | ID: mdl-34788896

8.

Generating Bioactive Natural Product-inspired Molecules with Machine Intelligence.

Schneider, Petra; Altmann, Karl-Heinz; Schneider, Gisbert.

Chimia (Aarau) ; 76(5): 396-401, 2022 May 25.

Article in English | MEDLINE | ID: mdl-38069710

9.

Structure, Function and Pharmacology of SLC7 Family Members and Homologues.

Jeckelmann, Jean-Marc; Zaugg, Jonas; Morozova, Veronika; Müller, Jennifer; Kantipudi, Satish; Schroeder, Mariana; Graff, Julien; Albrecht, Christiane; Altmann, Karl-Heinz; Gertsch, Jürg; Fotiadis, Dimitrios.

Chimia (Aarau) ; 76(12): 1011-1018, 2022 Dec 21.

Article in English | MEDLINE | ID: mdl-38069796

10.

Taxanes convert regions of perturbed microtubule growth into rescue sites.

Rai, Ankit; Liu, Tianyang; Glauser, Simon; Katrukha, Eugene A; Estévez-Gallego, Juan; Rodríguez-García, Ruddi; Fang, Wei-Shuo; Díaz, J Fernando; Steinmetz, Michel O; Altmann, Karl-Heinz; Kapitein, Lukas C; Moores, Carolyn A; Akhmanova, Anna.

Nat Mater ; 19(3): 355-365, 2020 03.

Article in English | MEDLINE | ID: mdl-31819210

11.

Synthesis of Morpholine-Based Analogues of (-)-Zampanolide and Their Biological Activity.

Bold, Christian Paul; Gut, Melanie; Schürmann, Jasmine; Lucena-Agell, Daniel; Gertsch, Jürg; Díaz, José Fernando; Altmann, Karl-Heinz.

Chemistry ; 27(19): 5936-5943, 2021 Apr 01.

Article in English | MEDLINE | ID: mdl-33078440

12.

Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides.

Müller, Alex T; Posselt, Gernot; Gabernet, Gisela; Neuhaus, Claudia; Bachler, Simon; Blatter, Markus; Pfeiffer, Bernhard; Hiss, Jan A; Dittrich, Petra S; Altmann, Karl-Heinz; Wessler, Silja; Schneider, Gisbert.

Biochemistry ; 59(39): 3772-3781, 2020 10 06.

Article in English | MEDLINE | ID: mdl-32936629

13.

Small molecule inhibitors provide insights into the relevance of LAT1 and LAT2 in materno-foetal amino acid transport.

Zaugg, Jonas; Huang, Xiao; Ziegler, Fabian; Rubin, Matthias; Graff, Julien; Müller, Jennifer; Moser-Hässig, Ruedi; Powell, Theresa; Gertsch, Jürg; Altmann, Karl-Heinz; Albrecht, Christiane.

J Cell Mol Med ; 24(21): 12681-12693, 2020 11.

Article in English | MEDLINE | ID: mdl-33001560

14.

Ammonia uptake by transmembrane pH gradient poly(isoprene)-block-poly(ethylene glycol) polymersomes.

Schmidt, Aaron C; Hebels, Erik R; Weitzel, Charlotte; Stoessel, Barbara; Bao, Yinyin; Altmann, Karl-Heinz; Leroux, Jean-Christophe.

Soft Matter ; 16(11): 2725-2735, 2020 Mar 18.

Article in English | MEDLINE | ID: mdl-32115597

15.

Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake.

Chicca, Andrea; Nicolussi, Simon; Bartholomäus, Ruben; Blunder, Martina; Aparisi Rey, Alejandro; Petrucci, Vanessa; Reynoso-Moreno, Ines Del Carmen; Viveros-Paredes, Juan Manuel; Dalghi Gens, Marianela; Lutz, Beat; Schiöth, Helgi B; Soeberdt, Michael; Abels, Christoph; Charles, Roch-Philippe; Altmann, Karl-Heinz; Gertsch, Jürg.

Proc Natl Acad Sci U S A ; 114(25): E5006-E5015, 2017 06 20.

Article in English | MEDLINE | ID: mdl-28584105

16.

Ring-Closing Metathesis Approaches towards the Total Synthesis of Rhizoxins.

Liniger, Marc; Neuhaus, Christian M; Altmann, Karl-Heinz.

Molecules ; 25(19)2020 Oct 02.

Article in English | MEDLINE | ID: mdl-33023218

17.

An RCM-Based Total Synthesis of the Antibiotic DisciformycinâB.

Waser, Philipp; Altmann, Karl-Heinz.

Angew Chem Int Ed Engl ; 59(40): 17393-17397, 2020 09 28.

Article in English | MEDLINE | ID: mdl-32558021

18.

Synthesis, Microtubule-Binding Affinity, and Antiproliferative Activity of New Epothilone Analogs and of an EGFR-Targeted Epothilone-Peptide Conjugate.

Gaugaz, Fabienne Zdenka; Chicca, Andrea; Redondo-Horcajo, Mariano; Barasoain, Isabel; Díaz, J Fernando; Altmann, Karl-Heinz.

Int J Mol Sci ; 20(5)2019 Mar 05.

Article in English | MEDLINE | ID: mdl-30841526

19.

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands.

Balaguer, Francisco de Asís; Mühlethaler, Tobias; Estévez-Gallego, Juan; Calvo, Enrique; Giménez-Abián, Juan Francisco; Risinger, April L; Sorensen, Erik J; Vanderwal, Christopher D; Altmann, Karl-Heinz; Mooberry, Susan L; Steinmetz, Michel O; Oliva, María Ángela; Prota, Andrea E; Díaz, J Fernando.

Int J Mol Sci ; 20(6)2019 Mar 20.

Article in English | MEDLINE | ID: mdl-30897704

20.

Total Synthesis of Ripostatin B and Structure-Activity Relationship Studies on Ripostatin Analogs.

Glaus, Florian; Dedic, Darija; Tare, Priyanka; Nagaraja, Valakunja; Rodrigues, Liliana; Aínsa, José Antonio; Kunze, Jens; Schneider, Gisbert; Hartkoorn, Ruben C; Cole, Stewart T; Altmann, Karl-Heinz.

J Org Chem ; 83(13): 7150-7172, 2018 07 06.

Article in English | MEDLINE | ID: mdl-29542926

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