ABSTRACT
The article covers results of long-standing research on clinical peculiarities and course of toxic encephalopathy in distant period of occupational neurointoxications, on main concepts and pathogenetic steps of formation and progress of toxic encephalopathy. Through investigation covered firemen after exposure to complex of toxic chemicals and patients in post-contact period of chronic mercury intoxication. Modelling of chronic inhalation of metallic mercury vapors was performed.
Subject(s)
Air Pollutants, Occupational/adverse effects , Neurotoxicity Syndromes/etiology , Neurotoxins/adverse effects , Occupational Diseases/chemically induced , Occupational Exposure/adverse effects , Smoke/adverse effects , Animals , Cognition/drug effects , Disease Models, Animal , Electroencephalography , Fires , Follow-Up Studies , Humans , Male , Mercury/toxicity , Mercury Poisoning, Nervous System/etiology , Mercury Poisoning, Nervous System/physiopathology , Neurotoxicity Syndromes/physiopathology , Occupational Diseases/physiopathology , RatsABSTRACT
Classic symptoms of manganese intoxication are very rarely seen nowadays. Clinic in Angarsk Research Institute for Occupational medicine and Human ecology registered two cases of stage I and II chronic manganese intoxication over 10 years among electric welders. The cases were diagnosed with consideration of long length of exposure to manganese with the ambient air level exceeding the MAC 1.5 times, the disease manifestation at middle age, high manganese level in serum and urine, characteristic neurologic symptoms in association with organic psychopathologic defects and polyneuropathy of limbs.
Subject(s)
Manganese Poisoning/etiology , Manganese/adverse effects , Occupational Diseases/chemically induced , Occupational Exposure/adverse effects , Welding , Diagnosis, Differential , Disease Progression , Electroencephalography , Follow-Up Studies , Humans , Male , Manganese/blood , Manganese/urine , Manganese Poisoning/diagnosis , Manganese Poisoning/metabolism , Middle Aged , Occupational Diseases/diagnosis , Occupational Diseases/metabolism , Tomography, X-Ray Computed , Ultrasonography, Doppler, TranscranialABSTRACT
The authors carried out a complex immunomorphological study of the peripheral blood lymphocytes in 160 healthy persons of different age groups. The tests of spontaneous and complementary rosette formation of lymphocyte blasttransformation with PHA were used, assessing it by the H3-thymidine incorporation, lymphocyte straining by Coon's direct and indirect methods for detection of surface immunoglobulin receptors; G, A, and M immunoglobulins blood serum content was studied by Mancini's method. Mean indices characterizing the T- and B-populations of lymphocytes in persons of different age were calculated on the basis of these studies.
Subject(s)
B-Lymphocytes/immunology , T-Lymphocytes/immunology , Adolescent , Adult , Age Factors , Aged , Binding Sites, Antibody , Child , Child, Preschool , Fluorescent Antibody Technique , Humans , Immune Adherence Reaction , Immunoglobulins , Infant, Newborn , Lectins , Lymphocyte ActivationABSTRACT
Using the complex of methods for recognition of surface lymphocyte receptors the authors examined 42 patients with chronic lymphatic leukemia and 30 healthy individuals. The reduced density of receptors on lymphocyte surface or their total absence is characteristic of the whole group of patients with chronic lymphatic leukemia. This atypism of leukemia lymphocytes is augmented in greater rate of neoplastic cells growth. Total synthesis of serum immunoglobulins in chronic lymphatic leukemia is found to be lowered, the fall being more sharp in increased amount of lymphocytes in peripheral blood.