Search | Virtual Health Library

1.

Lysophosphatidylcholines modulate immunoregulatory checkpoints in peripheral monocytes and are associated with mortality in people with acute liver failure.

Trovato, Francesca M; Zia, Rabiya; Artru, Florent; Mujib, Salma; Jerome, Ellen; Cavazza, Anna; Coen, Muireann; Wilson, Ian; Holmes, Elaine; Morgan, Phillip; Singanayagam, Arjuna; Bernsmeier, Christine; Napoli, Salvatore; Bernal, William; Wendon, Julia; Miquel, Rosa; Menon, Krishna; Patel, Vishal C; Smith, John; Atkinson, Stephen R; Triantafyllou, Evangelos; McPhail, Mark J W.

J Hepatol ; 78(3): 558-573, 2023 03.

Article in English | MEDLINE | ID: mdl-36370949

2.

Integrated Transcriptomic and Proteomic Analysis Identifies Plasma Biomarkers of Hepatocellular Failure in Alcohol-Associated Hepatitis.

Argemi, Josepmaria; Kedia, Komal; Gritsenko, Marina A; Clemente-Sanchez, Ana; Asghar, Aliya; Herranz, Jose M; Liu, Zhang-Xu; Atkinson, Stephen R; Smith, Richard D; Norden-Krichmar, Trina M; Day, Le Z; Stolz, Andrew; Tayek, John A; Bataller, Ramon; Morgan, Timothy R; Jacobs, Jon M.

Am J Pathol ; 192(12): 1658-1669, 2022 12.

Article in English | MEDLINE | ID: mdl-36243044

3.

A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers.

Whitfield, John B; Schwantes-An, Tae-Hwi; Darlay, Rebecca; Aithal, Guruprasad P; Atkinson, Stephen R; Bataller, Ramon; Botwin, Greg; Chalasani, Naga P; Cordell, Heather J; Daly, Ann K; Day, Christopher P; Eyer, Florian; Foroud, Tatiana; Gleeson, Dermot; Goldman, David; Haber, Paul S; Jacquet, Jean-Marc; Liang, Tiebing; Liangpunsakul, Suthat; Masson, Steven; Mathurin, Philippe; Moirand, Romain; McQuillin, Andrew; Moreno, Christophe; Morgan, Marsha Y; Mueller, Sebastian; Müllhaupt, Beat; Nagy, Laura E; Nahon, Pierre; Nalpas, Bertrand; Naveau, Sylvie; Perney, Pascal; Pirmohamed, Munir; Seitz, Helmut K; Soyka, Michael; Stickel, Felix; Thompson, Andrew; Thursz, Mark R; Trépo, Eric; Morgan, Timothy R; Seth, Devanshi.

J Hepatol ; 76(2): 275-282, 2022 02.

Article in English | MEDLINE | ID: mdl-34656649

4.

Serum transferrin as a biomarker of hepatocyte nuclear factor 4 alpha activity and hepatocyte function in liver diseases.

Guldiken, Nurdan; Argemi, Josepmaria; Gurbuz, Berivan; Atkinson, Stephen R; Oliverius, Martin; Fila, Petr; Hamesch, Karim; Bruns, Tony; Cabezas, Joaquín; Lozano, Juan J; Mann, Jelena; Cao, Sheng; Mathurin, Philippe; Shah, Vijay H; Trautwein, Christian; Thursz, Mark R; Bataller, Ramon; Strnad, Pavel.

BMC Med ; 19(1): 39, 2021 02 17.

Article in English | MEDLINE | ID: mdl-33593348

5.

Assessment and Management of Infection in Alcoholic Hepatitis.

Vergis, Nikhil; Atkinson, Stephen R; Thursz, Mark R.

Semin Liver Dis ; 40(1): 11-19, 2020 02.

Article in English | MEDLINE | ID: mdl-31370067

6.

In Severe Alcoholic Hepatitis, Serum Keratin-18 Fragments Are Diagnostic, Prognostic, and Theragnostic Biomarkers.

Atkinson, Stephen R; Grove, Jane I; Liebig, Stephanie; Astbury, Stuart; Vergis, Nikhil; Goldin, Robert; Quaglia, Alberto; Bantel, Heike; Guha, Indra Neil; Thursz, Mark R; Newcombe, Paul; Strnad, Pavel; Aithal, Guruprasad P.

Am J Gastroenterol ; 115(11): 1857-1868, 2020 11.

Article in English | MEDLINE | ID: mdl-33156105

7.

Serum Transferrin Is an Independent Predictor of Mortality in Severe Alcoholic Hepatitis.

Atkinson, Stephen R; Hamesch, Karim; Spivak, Igor; Guldiken, Nurdan; Cabezas, Joaquín; Argemi, Josepmaria; Theurl, Igor; Zoller, Heinz; Cao, Sheng; Mathurin, Philippe; Shah, Vijay H; Trautwein, Christian; Bataller, Ramon; Thursz, Mark R; Strnad, Pavel.

Am J Gastroenterol ; 115(3): 398-405, 2020 03.

Article in English | MEDLINE | ID: mdl-31985531

8.

Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo-a Meta-analysis of Individual Data From Controlled Trials.

Louvet, Alexandre; Thursz, Mark R; Kim, Dong Joon; Labreuche, Julien; Atkinson, Stephen R; Sidhu, Sandeep Singh; O'Grady, John G; Akriviadis, Evangelos; Sinakos, Emmanouil; Carithers, Robert L; Ramond, Marie-José; Maddrey, Willis C; Morgan, Timothy R; Duhamel, Alain; Mathurin, Philippe.

Gastroenterology ; 155(2): 458-468.e8, 2018 08.

Article in English | MEDLINE | ID: mdl-29738698

9.

Application of prognostic scores in the STOPAH trial: Discriminant function is no longer the optimal scoring system in alcoholic hepatitis.

Forrest, Ewan H; Atkinson, Stephen R; Richardson, Paul; Masson, Steven; Ryder, Stephen; Thursz, Mark R; Allison, Michael.

J Hepatol ; 68(3): 511-518, 2018 03.

Article in English | MEDLINE | ID: mdl-29175535

10.

In Patients With Severe Alcoholic Hepatitis, Prednisolone Increases Susceptibility to Infection and Infection-Related Mortality, and Is Associated With High Circulating Levels of Bacterial DNA.

Vergis, Nikhil; Atkinson, Stephen R; Knapp, Suzanne; Maurice, James; Allison, Michael; Austin, Andrew; Forrest, Ewan H; Masson, Steven; McCune, Anne; Patch, David; Richardson, Paul; Gleeson, Dermot; Ryder, Stephen D; Wright, Mark; Thursz, Mark R.

Gastroenterology ; 152(5): 1068-1077.e4, 2017 04.

Article in English | MEDLINE | ID: mdl-28043903

11.

Defective monocyte oxidative burst predicts infection in alcoholic hepatitis and is associated with reduced expression of NADPH oxidase.

Vergis, Nikhil; Khamri, Wafa; Beale, Kylie; Sadiq, Fouzia; Aletrari, Mina O; Moore, Celia; Atkinson, Stephen R; Bernsmeier, Christine; Possamai, Lucia A; Petts, Gemma; Ryan, Jennifer M; Abeles, Robin D; James, Sarah; Foxton, Matthew; Hogan, Brian; Foster, Graham R; O'Brien, Alastair J; Ma, Yun; Shawcross, Debbie L; Wendon, Julia A; Antoniades, Charalambos G; Thursz, Mark R.

Gut ; 66(3): 519-529, 2017 03.

Article in English | MEDLINE | ID: mdl-26860769

12.

Homozygosity for rs738409:G in PNPLA3 is associated with increased mortality following an episode of severe alcoholic hepatitis.

Atkinson, Stephen R; Way, Michael J; McQuillin, Andrew; Morgan, Marsha Y; Thursz, Mark R.

J Hepatol ; 67(1): 120-127, 2017 07.

Article in English | MEDLINE | ID: mdl-28161471

13.

Corrigendum to: 'A genetic risk score and diabetes predict development of alcohol-related cirrhosis in drinkers' [J Hepatol 2022 (76) 275-282].

Whitfield, John B; Schwantes-An, Tae-Hwi; Darlay, Rebecca; Aithal, Guruprasad P; Atkinson, Stephen R; Bataller, Ramon; Botwin, Greg; Chalasani, Naga P; Cordell, Heather J; Daly, Ann K; Day, Christopher P; Eyer, Florian; Foroud, Tatiana; Gleeson, Dermot; Goldman, David; Haber, Paul S; Jacquet, Jean-Marc; Liang, Tiebing; Liangpunsakul, Suthat; Masson, Steven; Mathurin, Philippe; Moirand, Romain; McQuillin, Andrew; Moreno, Christophe; Morgan, Marsha Y; Mueller, Sebastian; Müllhaupt, Beat; Nagy, Laura E; Nahon, Pierre; Nalpas, Bertrand; Naveau, Sylvie; Perney, Pascal; Pirmohamed, Munir; Seitz, Helmut K; Soyka, Michael; Stickel, Felix; Thompson, Andrew; Thursz, Mark R; Trépo, Eric; Morgan, Timothy R; Seth, Devanshi.

J Hepatol ; 76(5): 1244-1245, 2022 May.

Article in English | MEDLINE | ID: mdl-35287983

14.

Comparative Effectiveness of Pharmacological Interventions for Severe Alcoholic Hepatitis: A Systematic Review and Network Meta-analysis.

Singh, Siddharth; Murad, Mohammad Hassan; Chandar, Apoorva K; Bongiorno, Connie M; Singal, Ashwani K; Atkinson, Stephen R; Thursz, Mark R; Loomba, Rohit; Shah, Vijay H.

Gastroenterology ; 149(4): 958-70.e12, 2015 Oct.

Article in English | MEDLINE | ID: mdl-26091937

15.

Response to Diao et al.

Atkinson, Stephen R; Thursz, Mark R; Strnad, Pavel.

Am J Gastroenterol ; 115(6): 958, 2020 06.

Article in English | MEDLINE | ID: mdl-32427678

16.

Response to Sainath et al.

Atkinson, Stephen R; Thursz, Mark R; Strnad, Pavel.

Am J Gastroenterol ; 115(7): 1136-1137, 2020 07.

Article in English | MEDLINE | ID: mdl-32618669

17.

The future of therapy for alcoholic hepatitis - Beyond corticosteroids.

Vergis, Nikhil; Atkinson, Stephen R; Thursz, Mark R.

J Hepatol ; 70(4): 785-787, 2019 04.

Article in English | MEDLINE | ID: mdl-30791978

18.

ACG Clinical Guideline for Alcoholic Liver Disease: The MELD Threshold for Corticosteroid Treatment has Yet to be Established.

Forrest, Ewan H; Atkinson, Stephen R; Richardson, Paul; Masson, Steven; Ryder, Stephen; Thursz, Mark R; Allison, Michael.

Am J Gastroenterol ; 114(1): 175-176, 2019 01.

Article in English | MEDLINE | ID: mdl-29887598

19.

People who survive an episode of severe alcoholic hepatitis should be advised to maintain total abstinence from alcohol.

Atkinson, Stephen R; McQuillin, Andrew; Morgan, Marsha Y; Thursz, Mark R.

Hepatology ; 67(6): 2479-2480, 2018 06.

Article in English | MEDLINE | ID: mdl-29394458

20.

Therapeutic inhibition of monocyte recruitment prevents checkpoint inhibitor-induced hepatitis.

Gudd, Cathrin L C; Mitchell, Eoin; Atkinson, Stephen R; Mawhin, Marie-Anne; Turajlic, Samra; Larkin, James; Thursz, Mark R; Goldin, Robert D; Powell, Nick; Antoniades, Charalambos G; Woollard, Kevin J; Possamai, Lucia A; Triantafyllou, Evangelos.

J Immunother Cancer ; 12(4)2024 Apr 04.

Article in English | MEDLINE | ID: mdl-38580334

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