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1.
A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes.
J Biol Chem
; 296: 100345, 2021.
Article
in English
| MEDLINE | ID: mdl-33515548
2.
Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.
Proc Natl Acad Sci U S A
; 115(31): E7438-E7447, 2018 07 31.
Article
in English
| MEDLINE | ID: mdl-30012612
3.
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.
Proc Natl Acad Sci U S A
; 114(46): 12309-12314, 2017 11 14.
Article
in English
| MEDLINE | ID: mdl-29087309
4.
8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.
Chemistry
; 24(8): 1922-1930, 2018 Feb 06.
Article
in English
| MEDLINE | ID: mdl-29171692
5.
Chemical Tagging with tert-Butyl and Trimethylsilyl Groups for Measuring Intermolecular Nuclear Overhauser Effects in a Large Protein-Ligand Complex.
Chemistry
; 23(53): 13033-13036, 2017 Sep 21.
Article
in English
| MEDLINE | ID: mdl-28763128
6.
Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation.
Bioorg Med Chem Lett
; 27(2): 254-260, 2017 01 15.
Article
in English
| MEDLINE | ID: mdl-27923620
7.
Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist.
Proc Natl Acad Sci U S A
; 111(12): 4614-9, 2014 Mar 25.
Article
in English
| MEDLINE | ID: mdl-24619092
8.
Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.
Mol Pharmacol
; 90(6): 715-725, 2016 Dec.
Article
in English
| MEDLINE | ID: mdl-27683013
9.
Legumain is activated in macrophages during pancreatitis.
Am J Physiol Gastrointest Liver Physiol
; 311(3): G548-60, 2016 09 01.
Article
in English
| MEDLINE | ID: mdl-27514475
10.
Pulse EPR-enabled interpretation of scarce pseudocontact shifts induced by lanthanide binding tags.
J Biomol NMR
; 64(1): 39-51, 2016 Jan.
Article
in English
| MEDLINE | ID: mdl-26597990
11.
Mapping the Interactions of I2 , I(.) , I(-) , and I(+) with Alkynes and Their Roles in Iodocyclizations.
Chemistry
; 21(28): 10191-9, 2015 Jul 06.
Article
in English
| MEDLINE | ID: mdl-26043933
12.
Scaffold-divergent synthesis of ring-fused indoles, quinolines, and quinolones via iodonium-induced reaction cascades.
J Org Chem
; 78(10): 4708-18, 2013 May 17.
Article
in English
| MEDLINE | ID: mdl-23659428
13.
Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain.
Biomaterials
; 285: 121536, 2022 06.
Article
in English
| MEDLINE | ID: mdl-35533442
14.
The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor.
Bioorg Med Chem Lett
; 21(12): 3704-7, 2011 Jun 15.
Article
in English
| MEDLINE | ID: mdl-21612922
15.
New methodology for the N-alkylation of 2-amino-3-acylthiophenes.
Org Biomol Chem
; 9(13): 4886-902, 2011 Jul 07.
Article
in English
| MEDLINE | ID: mdl-21562651
16.
Delineating the mode of action of adenosine A1 receptor allosteric modulators.
Mol Pharmacol
; 78(3): 444-55, 2010 Sep.
Article
in English
| MEDLINE | ID: mdl-20547736
17.
A molecular sensor to quantify the localization of proteins, DNA and nanoparticles in cells.
Nat Commun
; 11(1): 4482, 2020 09 08.
Article
in English
| MEDLINE | ID: mdl-32901011
18.
Application of a Sulfoxonium Ylide Electrophile to Generate Cathepsin X-Selective Activity-Based Probes.
ACS Chem Biol
; 15(3): 718-727, 2020 03 20.
Article
in English
| MEDLINE | ID: mdl-32022538
19.
3- and 6-Substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists.
Bioorg Med Chem
; 17(20): 7353-61, 2009 Oct 15.
Article
in English
| MEDLINE | ID: mdl-19751980
20.
Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease.
Sci Rep
; 9(1): 13295, 2019 09 16.
Article
in English
| MEDLINE | ID: mdl-31527638