Search | Virtual Health Library

1.

RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention.

Dos Passos, Patricia M; Hemamali, Erandika H; Mamede, Lohany D; Hayes, Lindsey R; Ayala, Yuna M.

PLoS Biol ; 22(2): e3002527, 2024 Feb.

Article in English | MEDLINE | ID: mdl-38422113

2.

Specific RNA interactions promote TDP-43 multivalent phase separation and maintain liquid properties.

Grese, Zachary R; Bastos, Alliny Cs; Mamede, Lohany D; French, Rachel L; Miller, Timothy M; Ayala, Yuna M.

EMBO Rep ; 22(12): e53632, 2021 12 06.

Article in English | MEDLINE | ID: mdl-34787357

3.

TDP-43 α-helical structure tunes liquid-liquid phase separation and function.

Conicella, Alexander E; Dignon, Gregory L; Zerze, Gül H; Schmidt, Hermann Broder; D'Ordine, Alexandra M; Kim, Young C; Rohatgi, Rajat; Ayala, Yuna M; Mittal, Jeetain; Fawzi, Nicolas L.

Proc Natl Acad Sci U S A ; 117(11): 5883-5894, 2020 03 17.

Article in English | MEDLINE | ID: mdl-32132204

4.

Uncovering Critical Roles for RNA in Neurodegeneration.

Ayala, Yuna M.

Mo Med ; 120(5): 374-380, 2023.

Article in English | MEDLINE | ID: mdl-37841575

5.

A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.

Wang, Ailin; Conicella, Alexander E; Schmidt, Hermann Broder; Martin, Erik W; Rhoads, Shannon N; Reeb, Ashley N; Nourse, Amanda; Ramirez Montero, Daniel; Ryan, Veronica H; Rohatgi, Rajat; Shewmaker, Frank; Naik, Mandar T; Mittag, Tanja; Ayala, Yuna M; Fawzi, Nicolas L.

EMBO J ; 37(5)2018 03 01.

Article in English | MEDLINE | ID: mdl-29438978

6.

TDP-43 dysfunction results in R-loop accumulation and DNA replication defects.

Wood, Matthew; Quinet, Annabel; Lin, Yea-Lih; Davis, Albert A; Pasero, Philippe; Ayala, Yuna M; Vindigni, Alessandro.

J Cell Sci ; 133(20)2020 10 30.

Article in English | MEDLINE | ID: mdl-32989039

7.

RNA-Based Therapies for Neurodegenerative Diseases.

Ayala, Yuna M; Nguyen, Andrew D.

Mo Med ; 118(4): 340-345, 2021.

Article in English | MEDLINE | ID: mdl-34373669

8.

Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation.

French, Rachel L; Grese, Zachary R; Aligireddy, Himani; Dhavale, Dhruva D; Reeb, Ashley N; Kedia, Niraja; Kotzbauer, Paul T; Bieschke, Jan; Ayala, Yuna M.

J Biol Chem ; 294(17): 6696-6709, 2019 04 26.

Article in English | MEDLINE | ID: mdl-30824544

9.

Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function.

Li, Wen; Reeb, Ashley N; Lin, Binyan; Subramanian, Praveen; Fey, Erin E; Knoverek, Catherine R; French, Rachel L; Bigio, Eileen H; Ayala, Yuna M.

J Biol Chem ; 292(12): 5089-5100, 2017 03 24.

Article in English | MEDLINE | ID: mdl-28167528

10.

Seeding competent TDP-43 persists in human patient and mouse muscle.

Lynch, Eileen M; Pittman, Sara; Daw, Jil; Ikenaga, Chiseko; Chen, Sheng; Dhavale, Dhruva D; Jackrel, Meredith E; Ayala, Yuna M; Kotzbauer, Paul; Ly, Cindy V; Pestronk, Alan; Lloyd, Thomas E; Weihl, Conrad C.

bioRxiv ; 2024 Apr 04.

Article in English | MEDLINE | ID: mdl-38617354

11.

Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration.

Dermentzaki, Georgia; Furlan, Mattia; Tanaka, Iris; Leonardi, Tommaso; Rinchetti, Paola; Passos, Patricia M S; Bastos, Alliny; Ayala, Yuna M; Hanna, Jacob H; Przedborski, Serge; Bonanomi, Dario; Pelizzola, Mattia; Lotti, Francesco.

Cell Rep ; 43(4): 113999, 2024 Apr 23.

Article in English | MEDLINE | ID: mdl-38554281

12.

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates.

Yan, Xiao; Kuster, David; Mohanty, Priyesh; Nijssen, Jik; Pombo-García, Karina; Rizuan, Azamat; Franzmann, Titus M; Sergeeva, Aleksandra; Passos, Patricia M; George, Leah; Wang, Szu-Huan; Shenoy, Jayakrishna; Danielson, Helen L; Honigmann, Alf; Ayala, Yuna M; Fawzi, Nicolas L; Mittal, Jeetain; Alberti, Simon; Hyman, Anthony A.

bioRxiv ; 2024 May 24.

Article in English | MEDLINE | ID: mdl-38328053

13.

RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention.

Dos Passos, Patricia M; Hemamali, Erandika H; Mamede, Lohany D; Hayes, Lindsey R; Ayala, Yuna M.

bioRxiv ; 2023 Aug 07.

Article in English | MEDLINE | ID: mdl-37609278

14.

TDP-43 Oligomerization and Phase Separation Properties Are Necessary for Autoregulation.

Koehler, Lydia C; Grese, Zachary R; Bastos, Alliny C S; Mamede, Lohany D; Heyduk, Tomasz; Ayala, Yuna M.

Front Neurosci ; 16: 818655, 2022.

Article in English | MEDLINE | ID: mdl-35495061

15.

Finding a chaperone for TDP-43.

Ayala, Yuna M; Grese, Zachary R.

Nat Cell Biol ; 24(9): 1328-1330, 2022 09.

Article in English | MEDLINE | ID: mdl-36075973

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RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention.

Specific RNA interactions promote TDP-43 multivalent phase separation and maintain liquid properties.

TDP-43 α-helical structure tunes liquid-liquid phase separation and function.

Uncovering Critical Roles for RNA in Neurodegeneration.

A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing.

TDP-43 dysfunction results in R-loop accumulation and DNA replication defects.

RNA-Based Therapies for Neurodegenerative Diseases.

Detection of TAR DNA-binding protein 43 (TDP-43) oligomers as initial intermediate species during aggregate formation.

Heat Shock-induced Phosphorylation of TAR DNA-binding Protein 43 (TDP-43) by MAPK/ERK Kinase Regulates TDP-43 Function.

Seeding competent TDP-43 persists in human patient and mouse muscle.

Depletion of Mettl3 in cholinergic neurons causes adult-onset neuromuscular degeneration.

Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates.

RNA-mediated ribonucleoprotein assembly controls TDP-43 nuclear retention.

TDP-43 Oligomerization and Phase Separation Properties Are Necessary for Autoregulation.

Finding a chaperone for TDP-43.