Combined autologous chondrocyte implantation and allogenic meniscus transplantation: a biological knee replacement.

Meniscus deficient knees develop early osteoarthritis in the knee. Autologous Chondrocyte Implantation has provided a new dimension to the treatment of chondral defects in the knee, with 85% good to excellent results and a long-term durable outcome of up-to 11 years. However, it is contraindicated in meniscus deficient knees. Allogenic Meniscus Transplantation gives good symptomatic relief in meniscus deficient knees, with a success rate of 89%. However, it is contraindicated in advanced cartilage degeneration. We hypothesized that combination of these two might be a solution for bone-on-bone arthritis in young individuals. We studied a consecutive series of eight patients, with mean age of 43 years, presenting with large kissing chondral defects, secondary to the previous meniscectomy. All the patients were treated with a combination of Autologous Chondrocyte Implantation and Allogenic Meniscus Transplantation. Mean pre-operative Lysholm score was 49, which rose to mean of 66 at 1 year, an average increase by 16.4 points. Six patients showed significant improvement at one year. MRI scans showed good integration of the menisci with the capsule, without any rejection. Histology confirmed the integration. All the patients could lead an active life-style. Five patients maintained the improvement at a mean follow-up of 3.2 years. We could not find any deleterious effects of the combination of these two techniques. So we conclude that the combination of these two techniques together may act a one step towards a true biological knee replacement.

Prevalence of respiratory symptoms, bronchial hyperreactivity, and asthma in a megacity. Results of the European community respiratory health survey in Mumbai (Bombay).

To estimate adult asthma prevalence in the world's most rapidly growing mega-city, we applied epidemiologic surveillance tools, as a cooperating center of the European Community Respiratory Health Survey, to a randomly selected sample of Mumbai (Bombay) residents in 1992 through 1995. From a metropolitan population of over 10 million, we took a one-in-ten random sample from electoral rolls in a socially diverse residential district, and examined asthma symptoms in adults age 20 to 44 yr. In Phase I, we interviewed 2,313 adults about symptoms, asthma diagnosis, and medications in the previous 12 mo. In Phase II, family and smoking history, socioeconomic data, housing characteristics, serum IgE, allergy skin tests, spirometry, and methacholine challenge tests were obtained in a subset of 20% of those who had completed Phase I. House dust mite was the most common positive skin test (18% prevalence) and the only one of the nine applied that was significantly associated with asthma symptoms and physician-diagnosed asthma. Asthma prevalence was 3.5% by physician diagnosis, and 17% using a very broad definition including those with asymptomatic bronchial hyperreactivity. Asthma prevalence was strongly associated with positive house dust mite skin test, family history of asthma, and total IgE.