Non-Invasive Ultrasound Diagnostic Techniques for Steatotic Liver Disease and Focal Liver Lesions: 2D, Colour Doppler, 3D, Two-Dimensional Shear Wave Elastography (2D-SWE), and Ultrasound-Guided Attenuation Parameter (UGAP).

We conducted a comprehensive literature review to evaluate the efficacy of combining two-dimensional shear wave elastography (2D-SWE) and ultrasound-guided attenuation parameter (UGAP) in assessing the risk of progressive metabolic dysfunction-associated steatohepatitis (MASH). This narrative review explores the applications of liver ultrasound in diagnosing metabolic liver diseases, focusing on recent advancements in diagnostic techniques for steatotic liver disease (SLD). Liver ultrasound can detect a spectrum of SLD manifestations, from metabolic dysfunction-associated liver disease (MASLD) to fibrosis and cirrhosis. It is also possible to identify inflammation, hepatitis, hepatocellular carcinoma (HCC), and various other liver lesions. Innovative ultrasound applications, including elastography and UGAP, can significantly enhance the diagnostic capabilities of ultrasound in accurately interpreting liver diseases. Understanding the pathogenesis of liver diseases requires a thorough analysis of their etiology and progression in order to develop sound diagnostic and therapeutic approaches. Chronic liver diseases (CLD) vary in origin, with MASLD affecting approximately 20-25% of the general population. The insidious progression of CLD from inflammation to fibrosis and cirrhosis underscores the need for effective early detection methods. This review aims to highlight the evolving role of non-invasive ultrasound-based diagnostic tests in the early detection and staging of liver diseases. By synthesizing current evidence, we aim to provide an updated perspective on the utility of advanced ultrasound techniques in redefining the diagnostic landscape for metabolic liver diseases.

Early Infirmaries in Methoni During the Venetian Occupation.

INTRODUCTION: In the High Middle Ages, Venetian sovereignty was recognized in Methoni and Koroni (in Greece). It helped lay the foundations for the prevalence of democracy in Venice in the Eastern Mediterranean. The development of these two decadent regions of Messinia, had to be supported by social welfare infrastructure. Today, the search for these social welfare infrastructures in Venetian Methoni at the beginning of the conquest turns mainly to the monasteries of the Latin monastic orders that settled there during that time. These spiritual institutions, which provided shelter, hospitality, and even medical care to those in need, have not been identified to date. OBJECTIVES AND METHODS: The goal of this paper is to propose two possible locations based on bibliographic and on-site research. With the help of bibliographies, Venetian files, and relevant wills from the time, an effort was made to identify these ruins. On-field research was carried out to consolidate the findings that arose from the analysis of bibliographic references, the evidence arising from them, as well as local tradition. RESULTS AND CONCLUSION: The monastery of the Cistercian nuns shows that, in the context of charity, medical care was provided to those in need. The monastery in Paliomothoni was one of the earliest infirmaries in Venetian Methoni. The location of the first infirmary of Venetian Methoni within the Cistercian monastery of Paliomothoni is highly probable. Additionally, it was found to be operating there by Dominican monks at a later time.

The Hospital of Medieval Venetian Methoni.

In medieval Venetian Methoni, the provision of medical care could be roughly divided into two phases. During the first phase, Venice provided medical care solely to the staff, the garrison, and the Venetian citizens residing in Methoni. Medical care to the rest of the population was offered by the solitary orders that had settled in the area after the conquest of Methoni, in the context of charity. In the second phase, when trade with the East and also the pilgrimages to the Holy Places increased, the Senate took over medical care, initially by subsidizing the local monasteries and later, according to a decision made by the Senate of Venice since 1423, by taking over the provision from its own hospital, which was located in the residential area of the castle, dedicated to Saint Johannes the Theologian (Evangelist).