[Use of interferon inducers and reaferon in the combined therapy of acute viral hepatitis B]. / Primenenie interferonogenov i reaferona v kompleksnoi terapii ostrogo virusnogo gepatita B.

The therapeutic effectiveness of interferon inducers (prodigiozan and ibuprofen), the Soviet drug reaferon and their combined use in acute viral hepatitis type B was studied. Indications for their use resulted from lowered capacity of the body for interferonogenesis at the height of the disease. The above drugs stimulated cellular immunity, promoted more rapid disappearance of clinical symptoms of disease, and reduced the period of hospital treatment. A more marked therapeutic effect was noted in combined administration of reaferon and ibuprofen.

[Immediate hypersensitivity reaction in acute viral hepatitis A and B treated with interferon inducers]. / Reaktsii nemedlennoi allergii pri ostrykh virusnykh gepatitakh A i B pri lechenii induktorami interferonoobrazovaniia.

The therapeutic effects of prodigiozan and ibuprofen, endogenous interferon production inductors, were studied in the patients with acute viral hepatitides A and B with consideration for the body allergic reactivity at the peak of the disease. The results evidence a favourable effect of these drugs on the clinical course of the disease and on liver function; immuno- and interferon-stimulating and desensitizing effects manifested mainly in hepatitis A cases with immediate types II and III hypersensitivity and in hepatitis B cases with immediate types I and II hypersensitivity.