1.
Pediatr Nephrol
; 24(9): 1761-3, 2009 Sep.
Article
in English
| MEDLINE
| ID: mdl-19373493
ABSTRACT
Current therapy for congenital nephrogenic diabetes insipidus consists of appropriate water intake coupled with decreased urine output obtained by means of a low-sodium diet and a combination of thiazide diuretics with renal prostaglandins inhibitors or amiloride. We report a case of congenital nephrogenic diabetes insipidus that was complicated by paradoxical water intoxication secondary to liberal water intake and the initiation of hydrochlorothiazide and indomethacin combination therapy. This report emphasizes the importance of evaluating the water balance and of a quick response with strict protocols following the initiation of indomethacin and thiazide diuretics in nephrogenic diabetes insipidus.
Subject(s)
Amiloride/therapeutic use , Cyclooxygenase Inhibitors/therapeutic use , Diabetes Insipidus, Nephrogenic/therapy , Diet, Sodium-Restricted , Diuretics/therapeutic use , Hydrochlorothiazide/therapeutic use , Indomethacin/therapeutic use , Combined Modality Therapy , Diabetes Insipidus, Nephrogenic/congenital , Diabetes Insipidus, Nephrogenic/genetics , Drug Therapy, Combination , Genetic Diseases, X-Linked , Humans , Infant , Male , Mutation , Receptors, Vasopressin/genetics , Treatment Outcome , Urination/drug effects , Water Intoxication/drug therapy , Water Intoxication/etiology
2.
Pediatr Nephrol
; 26(7): 1175-6, 2011 Jul.
Article
in English
| MEDLINE
| ID: mdl-21359961