Search | Virtual Health Library

1.

Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.

Liu, Ce Feng; Brandt, Gabriel S; Hoang, Quyen Q; Naumova, Natalia; Lazarevic, Vanja; Hwang, Eun Sook; Dekker, Job; Glimcher, Laurie H; Ringe, Dagmar; Petsko, Gregory A.

Proc Natl Acad Sci U S A ; 113(43): E6572-E6581, 2016 10 25.

Article in English | MEDLINE | ID: mdl-27791029

2.

The anthraquinone emodin inhibits the non-exported FIKK kinase from Plasmodium falciparum.

Lin, Benjamin C; Harris, Darcy R; Kirkman, Lucy M D; Perez, Astrid M; Qian, Yiwen; Schermerhorn, Janse T; Hong, Min Y; Winston, Dennis S; Xu, Lingyin; Lieber, Alexander M; Hamilton, Matthew; Brandt, Gabriel S.

Bioorg Chem ; 75: 217-223, 2017 12.

Article in English | MEDLINE | ID: mdl-28987877

3.

Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.

Naffin-Olivos, Jacqueline L; Georgieva, Maria; Goldfarb, Nathan; Madan-Lala, Ranjna; Dong, Lauren; Bizzell, Erica; Valinetz, Ethan; Brandt, Gabriel S; Yu, Sarah; Shabashvili, Daniil E; Ringe, Dagmar; Dunn, Ben M; Petsko, Gregory A; Rengarajan, Jyothi.

PLoS Pathog ; 10(5): e1004132, 2014 May.

Article in English | MEDLINE | ID: mdl-24830429

4.

SARS-CoV-2 virtual biochemistry labs on bioinformatics and drug design.

Brandt, Gabriel S; Novak, Walter R P.

Biochem Mol Biol Educ ; 49(1): 26-28, 2021 01.

Article in English | MEDLINE | ID: mdl-33301634

5.

Thermal stability and structure of glyceraldehyde-3-phosphate dehydrogenase from the coral Acropora millepora.

Perez, Astrid M; Wolfe, Jacob A; Schermerhorn, Janse T; Qian, Yiwen; Cela, Bekim A; Kalinowski, Cody R; Largoza, Garrett E; Fields, Peter A; Brandt, Gabriel S.

RSC Adv ; 11(17): 10364-10374, 2021 Mar 05.

Article in English | MEDLINE | ID: mdl-35423531

6.

Active-site engineering of benzaldehyde lyase shows that a point mutation can confer both new reactivity and susceptibility to mechanism-based inhibition.

Brandt, Gabriel S; Kneen, Malea M; Petsko, Gregory A; Ringe, Dagmar; McLeish, Michael J.

J Am Chem Soc ; 132(2): 438-9, 2010 Jan 20.

Article in English | MEDLINE | ID: mdl-20030408

7.

Detection and time course of formation of major thiamin diphosphate-bound covalent intermediates derived from a chromophoric substrate analogue on benzoylformate decarboxylase.

Chakraborty, Sumit; Nemeria, Natalia S; Balakrishnan, Anand; Brandt, Gabriel S; Kneen, Malea M; Yep, Alejandra; McLeish, Michael J; Kenyon, George L; Petsko, Gregory A; Ringe, Dagmar; Jordan, Frank.

Biochemistry ; 48(5): 981-94, 2009 Feb 10.

Article in English | MEDLINE | ID: mdl-19140682

8.

Snapshot of a reaction intermediate: analysis of benzoylformate decarboxylase in complex with a benzoylphosphonate inhibitor.

Brandt, Gabriel S; Kneen, Malea M; Chakraborty, Sumit; Baykal, Ahmet T; Nemeria, Natalia; Yep, Alejandra; Ruby, David I; Petsko, Gregory A; Kenyon, George L; McLeish, Michael J; Jordan, Frank; Ringe, Dagmar.

Biochemistry ; 48(15): 3247-57, 2009 Apr 21.

Article in English | MEDLINE | ID: mdl-19320438

9.

Immunomodulatory Effects of Flavonoids: Possible Induction of T CD4+ Regulatory Cells Through Suppression of mTOR Pathway Signaling Activity.

Hosseinzade, Aysooda; Sadeghi, Omid; Naghdipour Biregani, Akram; Soukhtehzari, Sepideh; Brandt, Gabriel S; Esmaillzadeh, Ahmad.

Front Immunol ; 10: 51, 2019.

Article in English | MEDLINE | ID: mdl-30766532

10.

Retraction.

Lee, Ann-Hwee; Brandt, Gabriel S; Iwakoshi, Neal N; Schinzel, Anna; Glimcher, Laurie H.

Science ; 384(6693): 280, 2024 Apr 19.

Article in English | MEDLINE | ID: mdl-38669582

11.

Probing the active center of benzaldehyde lyase with substitutions and the pseudosubstrate analogue benzoylphosphonic acid methyl ester.

Brandt, Gabriel S; Nemeria, Natalia; Chakraborty, Sumit; McLeish, Michael J; Yep, Alejandra; Kenyon, George L; Petsko, Gregory A; Jordan, Frank; Ringe, Dagmar.

Biochemistry ; 47(29): 7734-43, 2008 Jul 22.

Article in English | MEDLINE | ID: mdl-18570438

12.

Re-refinement of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase provides a clearer picture of an important malarial drug target.

Novak, Walter R P; West, Korbin H J; Kirkman, Lucy M D; Brandt, Gabriel S.

Acta Crystallogr F Struct Biol Commun ; 74(Pt 10): 664-668, 2018 Oct 01.

Article in English | MEDLINE | ID: mdl-30279319

13.

FIKK Kinase, a Ser/Thr Kinase Important to Malaria Parasites, Is Inhibited by Tyrosine Kinase Inhibitors.

Lin, Benjamin C; Harris, Darcy R; Kirkman, Lucy M D; Perez, Astrid M; Qian, Yiwen; Schermerhorn, Janse T; Hong, Min Y; Winston, Dennis S; Xu, Lingyin; Brandt, Gabriel S.

ACS Omega ; 2(10): 6605-6612, 2017 Oct 31.

Article in English | MEDLINE | ID: mdl-30023525

14.

Caging proteins through unnatural amino acid mutagenesis.

Petersson, E James; Brandt, Gabriel S; Zacharias, Niki M; Dougherty, Dennis A; Lester, Henry A.

Methods Enzymol ; 360: 258-73, 2003.

Article in English | MEDLINE | ID: mdl-12622154

15.

Dematin, a human erythrocyte cytoskeletal protein, is a substrate for a recombinant FIKK kinase from Plasmodium falciparum.

Brandt, Gabriel S; Bailey, Scott.

Mol Biochem Parasitol ; 191(1): 20-3, 2013 Sep.

Article in English | MEDLINE | ID: mdl-23973789

16.

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha.

Hetz, Claudio; Bernasconi, Paula; Fisher, Jill; Lee, Ann-Hwee; Bassik, Michael C; Antonsson, Bruno; Brandt, Gabriel S; Iwakoshi, Neal N; Schinzel, Anna; Glimcher, Laurie H; Korsmeyer, Stanley J.

Science ; 312(5773): 572-6, 2006 Apr 28.

Article in English | MEDLINE | ID: mdl-16645094

17.

Caged phosphoproteins.

Rothman, Deborah M; Petersson, E James; Vázquez, M Eugenio; Brandt, Gabriel S; Dougherty, Dennis A; Imperiali, Barbara.

J Am Chem Soc ; 127(3): 846-7, 2005 Jan 26.

Article in English | MEDLINE | ID: mdl-15656617

18.

Cation-pi interactions in ligand recognition by serotonergic (5-HT3A) and nicotinic acetylcholine receptors: the anomalous binding properties of nicotine.

Beene, Darren L; Brandt, Gabriel S; Zhong, Wenge; Zacharias, Niki M; Lester, Henry A; Dougherty, Dennis A.

Biochemistry ; 41(32): 10262-9, 2002 Aug 13.

Article in English | MEDLINE | ID: mdl-12162741

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