Search | Virtual Health Library

1.

Clostridioides difficile-Associated Antibiotics Alter Human Mucosal Barrier Functions by Microbiome-Independent Mechanisms.

Kester, Jemila C; Brubaker, Douglas K; Velazquez, Jason; Wright, Charles; Lauffenburger, Douglas A; Griffith, Linda G.

Antimicrob Agents Chemother ; 64(4)2020 03 24.

Article in English | MEDLINE | ID: mdl-31988098

2.

Computational translation of genomic responses from experimental model systems to humans.

Brubaker, Douglas K; Proctor, Elizabeth A; Haigis, Kevin M; Lauffenburger, Douglas A.

PLoS Comput Biol ; 15(1): e1006286, 2019 01.

Article in English | MEDLINE | ID: mdl-30629591

3.

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites.

Ball, Brendan K; Kuhn, Madison K; Fleeman Bechtel, Rebecca M; Proctor, Elizabeth A; Brubaker, Douglas K.

Sci Rep ; 14(1): 12743, 2024 06 03.

Article in English | MEDLINE | ID: mdl-38830911

4.

Detailed survey of an in vitro intestinal epithelium model by single-cell transcriptomics.

Ran, Ran; Muñoz Briones, Javier; Jena, Smrutiti; Anderson, Nicole L; Olson, Matthew R; Green, Leopold N; Brubaker, Douglas K.

iScience ; 27(4): 109383, 2024 Apr 19.

Article in English | MEDLINE | ID: mdl-38523788

5.

Enhanced annotation of CD45RA to distinguish T cell subsets in single-cell RNA-seq via machine learning.

Ran, Ran; Brubaker, Douglas K.

Bioinform Adv ; 3(1): vbad159, 2023.

Article in English | MEDLINE | ID: mdl-38023329

6.

TRANS-OMIC KNOWLEDGE TRANSFER MODELING INFERS GUT MICROBIOME BIOMARKERS OF ANTI-TNF RESISTANCE IN ULCERATIVE COLITIS.

Trinh, Alan; Ran, Ran; Brubaker, Douglas K.

Pac Symp Biocomput ; 28: 287-298, 2023.

Article in English | MEDLINE | ID: mdl-36540985

7.

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites.

Ball, Brendan K; Kuhn, Madison K; Fleeman, Rebecca M; Proctor, Elizabeth A; Brubaker, Douglas K.

bioRxiv ; 2023 Nov 17.

Article in English | MEDLINE | ID: mdl-38014333

8.

Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling.

Berard, Alicia R; Brubaker, Douglas K; Birse, Kenzie; Lamont, Alana; Mackelprang, Romel D; Noël-Romas, Laura; Perner, Michelle; Hou, Xuanlin; Irungu, Elizabeth; Mugo, Nelly; Knodel, Samantha; Muwonge, Timothy R; Katabira, Elly; Hughes, Sean M; Levy, Claire; Calienes, Fernanda L; Lauffenburger, Douglas A; Baeten, Jared M; Celum, Connie; Hladik, Florian; Lingappa, Jairam; Burgener, Adam D.

Cell Rep ; 42(5): 112474, 2023 05 30.

Article in English | MEDLINE | ID: mdl-37149863

9.

Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes.

Pendyala, Meghana; Woods, Paige S; Brubaker, Douglas K; Blaber, Elizabeth A; Schmidt, Tannin A; Chan, Deva D.

PLoS One ; 17(12): e0267921, 2022.

Article in English | MEDLINE | ID: mdl-36576921

10.

Computational Interspecies Translation Between Alzheimer's Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging.

Lee, Meelim J; Wang, Chuangqi; Carroll, Molly J; Brubaker, Douglas K; Hyman, Bradley T; Lauffenburger, Douglas A.

Front Neurosci ; 15: 727784, 2021.

Article in English | MEDLINE | ID: mdl-34658769

11.

Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation.

Suarez-Lopez, Lucia; Shui, Bing; Brubaker, Douglas K; Hill, Marza; Bergendorf, Alexander; Changelian, Paul S; Laguna, Aisha; Starchenko, Alina; Lauffenburger, Douglas A; Haigis, Kevin M.

iScience ; 24(12): 103406, 2021 Dec 17.

Article in English | MEDLINE | ID: mdl-34849469

12.

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model.

Proctor, Elizabeth A; Dineen, Shauna M; Van Nostrand, Stephen C; Kuhn, Madison K; Barrett, Christopher D; Brubaker, Douglas K; Yaffe, Michael B; Lauffenburger, Douglas A; Leon, Lisa R.

J Thromb Haemost ; 18(8): 1900-1910, 2020 08.

Article in English | MEDLINE | ID: mdl-32367690

13.

An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease.

Brubaker, Douglas K; Kumar, Manu P; Chiswick, Evan L; Gregg, Cecil; Starchenko, Alina; Vega, Paige N; Southard-Smith, Austin N; Simmons, Alan J; Scoville, Elizabeth A; Coburn, Lori A; Wilson, Keith T; Lau, Ken S; Lauffenburger, Douglas A.

Sci Signal ; 13(643)2020 08 04.

Article in English | MEDLINE | ID: mdl-32753478

14.

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation.

Brubaker, Douglas K; Paulo, Joao A; Sheth, Shikha; Poulin, Emily J; Popow, Olesja; Joughin, Brian A; Strasser, Samantha Dale; Starchenko, Alina; Gygi, Steven P; Lauffenburger, Douglas A; Haigis, Kevin M.

Cell Syst ; 9(3): 258-270.e6, 2019 09 25.

Article in English | MEDLINE | ID: mdl-31521603

15.

Substrate-based kinase activity inference identifies MK2 as driver of colitis.

Strasser, Samantha Dale; Ghazi, Phaedra C; Starchenko, Alina; Boukhali, Myriam; Edwards, Amanda; Suarez-Lopez, Lucia; Lyons, Jesse; Changelian, Paul S; Monahan, Joseph B; Jacobsen, Jon; Brubaker, Douglas K; Joughin, Brian A; Yaffe, Michael B; Haas, Wilhelm; Lauffenburger, Douglas A; Haigis, Kevin M.

Integr Biol (Camb) ; 11(7): 301-314, 2019 11 26.

Article in English | MEDLINE | ID: mdl-31617572

16.

Tissue-Specific Oncogenic Activity of KRAS^A146T.

Poulin, Emily J; Bera, Asim K; Lu, Jia; Lin, Yi-Jang; Strasser, Samantha Dale; Paulo, Joao A; Huang, Tannie Q; Morales, Carolina; Yan, Wei; Cook, Joshua; Nowak, Jonathan A; Brubaker, Douglas K; Joughin, Brian A; Johnson, Christian W; DeStefanis, Rebecca A; Ghazi, Phaedra C; Gondi, Sudershan; Wales, Thomas E; Iacob, Roxana E; Bogdanova, Lana; Gierut, Jessica J; Li, Yina; Engen, John R; Perez-Mancera, Pedro A; Braun, Benjamin S; Gygi, Steven P; Lauffenburger, Douglas A; Westover, Kenneth D; Haigis, Kevin M.

Cancer Discov ; 9(6): 738-755, 2019 06.

Article in English | MEDLINE | ID: mdl-30952657

17.

Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis.

Lyons, Jesse; Brubaker, Douglas K; Ghazi, Phaedra C; Baldwin, Katherine R; Edwards, Amanda; Boukhali, Myriam; Strasser, Samantha Dale; Suarez-Lopez, Lucia; Lin, Yi-Jang; Yajnik, Vijay; Kissil, Joseph L; Haas, Wilhelm; Lauffenburger, Douglas A; Haigis, Kevin M.

Sci Signal ; 11(519)2018 02 27.

Article in English | MEDLINE | ID: mdl-29487189

18.

Translating preclinical models to humans.

Brubaker, Douglas K; Lauffenburger, Douglas A.

Science ; 367(6479): 742-743, 2020 Feb 14.

Article in English | MEDLINE | ID: mdl-32054749

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Clostridioides difficile-Associated Antibiotics Alter Human Mucosal Barrier Functions by Microbiome-Independent Mechanisms.

Computational translation of genomic responses from experimental model systems to humans.

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites.

Detailed survey of an in vitro intestinal epithelium model by single-cell transcriptomics.

Enhanced annotation of CD45RA to distinguish T cell subsets in single-cell RNA-seq via machine learning.

TRANS-OMIC KNOWLEDGE TRANSFER MODELING INFERS GUT MICROBIOME BIOMARKERS OF ANTI-TNF RESISTANCE IN ULCERATIVE COLITIS.

Differential responses of primary neuron-secreted MCP-1 and IL-9 to type 2 diabetes and Alzheimer's disease-associated metabolites.

Vaginal epithelial dysfunction is mediated by the microbiome, metabolome, and mTOR signaling.

Endogenous production of hyaluronan, PRG4, and cytokines is sensitive to cyclic loading in synoviocytes.

Computational Interspecies Translation Between Alzheimer's Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging.

Cross-species transcriptomic signatures predict response to MK2 inhibition in mouse models of chronic inflammation.

Coagulopathy signature precedes and predicts severity of end-organ heat stroke pathology in a mouse model.

An interspecies translation model implicates integrin signaling in infliximab-resistant inflammatory bowel disease.

Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation.

Substrate-based kinase activity inference identifies MK2 as driver of colitis.

Tissue-Specific Oncogenic Activity of KRAS^A146T.

Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis.

Translating preclinical models to humans.