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1.
Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6.
J Am Chem Soc
; 145(18): 10015-10021, 2023 05 10.
Article
in English
| MEDLINE | ID: mdl-37104712
2.
K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Nature
; 547(7663): 364-368, 2017 07 20.
Article
in English
| MEDLINE | ID: mdl-28693035
3.
Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains.
J Pharmacol Exp Ther
; 355(1): 2-12, 2015 Oct.
Article
in English
| MEDLINE | ID: mdl-26224882
4.
Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease.
Bioorg Med Chem Lett
; 25(21): 4834-4837, 2015 Nov 01.
Article
in English
| MEDLINE | ID: mdl-26144347
5.
Hsp90 inhibitors as new leads to target parasitic diarrheal diseases.
Antimicrob Agents Chemother
; 58(7): 4138-44, 2014 Jul.
Article
in English
| MEDLINE | ID: mdl-24820073
6.
Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice.
J Pharmacol Exp Ther
; 347(2): 325-38, 2013 Nov.
Article
in English
| MEDLINE | ID: mdl-23965382
7.
Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.
Beilstein J Org Chem
; 9: 15-25, 2013.
Article
in English
| MEDLINE | ID: mdl-23400640
8.
Development of covalent chemogenetic K2P channel activators.
bioRxiv
; 2023 Oct 18.
Article
in English
| MEDLINE | ID: mdl-37905049
9.
Predicting binding to p-glycoprotein by flexible receptor docking.
PLoS Comput Biol
; 7(6): e1002083, 2011 Jun.
Article
in English
| MEDLINE | ID: mdl-21731480
10.
Pyrvinium Pamoate and Structural Analogs Are Early Macrofilaricide Leads.
Pharmaceuticals (Basel)
; 15(2)2022 Feb 02.
Article
in English
| MEDLINE | ID: mdl-35215301
11.
SAR studies on dihydropyrimidinone antibiotics.
Bioorg Med Chem Lett
; 21(6): 1670-4, 2011 Mar 15.
Article
in English
| MEDLINE | ID: mdl-21324685
12.
Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases.
Bioorg Med Chem Lett
; 19(21): 6218-21, 2009 Nov 01.
Article
in English
| MEDLINE | ID: mdl-19773167
13.
Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels.
ACS Chem Neurosci
; 9(12): 3153-3165, 2018 12 19.
Article
in English
| MEDLINE | ID: mdl-30089357
14.
Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.
J Med Chem
; 48(24): 7520-34, 2005 Dec 01.
Article
in English
| MEDLINE | ID: mdl-16302794
15.
Lead identification to clinical candidate selection: drugs for Chagas disease.
J Biomol Screen
; 20(1): 101-11, 2015 Jan.
Article
in English
| MEDLINE | ID: mdl-25281737
16.
2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease.
ChemMedChem
; 8(5): 847-57, 2013 May.
Article
in English
| MEDLINE | ID: mdl-23509039
17.
Divergent modes of enzyme inhibition in a homologous structure-activity series.
J Med Chem
; 52(16): 5005-8, 2009 Aug 27.
Article
in English
| MEDLINE | ID: mdl-19637873
18.
Cartilage thickness measurements from optical coherence tomography.
J Opt Soc Am A Opt Image Sci Vis
; 20(2): 357-67, 2003 Feb.
Article
in English
| MEDLINE | ID: mdl-12570303
19.
Peptidic 1-cyanopyrrolidines: synthesis and SAR of a series of potent, selective cathepsin inhibitors.
Bioorg Med Chem
; 10(10): 3277-84, 2002 Oct.
Article
in English
| MEDLINE | ID: mdl-12150873
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