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1.
Rep Pract Oncol Radiother ; 25(6): 902-905, 2020.
Article in English | MEDLINE | ID: mdl-32982598

ABSTRACT

This paper describes the role of the Polish Secondary Standard Dosimetry Laboratory (SSDL) in quality assurance in radiotherapy by means of providing calibration of ionisation chambers, TLD postal dosimetry audits and end-to-end audits for radiation therapy. A historical review of the methods and results are presented. The influence of the SSDL in Warsaw on radiation protection of patients in Poland is discussed. The International Atomic Energy Agency together with World Health Organisation (IAEA/WHO), through its network of SSDLs around the world, propagates newly developed methods for calibration and auditing. Suitable high quality equipment was provided by the IAEA, as well as special materials and technical support to the SSDL in Warsaw. The activity of the SSDL and the services provided for Polish radiotherapy centres have resulted in a reduction of discrepancies between planned doses and doses delivered to patients. The newly tested IAEA methods of end-to-end on-site dosimetry audits allow for monitoring and improving the quality of IMRT in Poland. The traceability of standards used for the calibration of therapy level dosimeters from Polish radiotherapy centres is assured by the IAEA dosimetry laboratory. The consistency of methods performed in the Polish SSDL with the ISO:17025 norm is supervised by the Polish Centre for Accreditation - a member of International Laboratory Accreditation Cooperation (ILAC), for calibration and testing. Due to the rapid technological development of radiotherapy, special attention has to be paid to newly developed methods for dosimetry auditing and institutions which provide services for assuring radiation safety of patients.

2.
Acta Oncol ; 58(12): 1731-1739, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31423867

ABSTRACT

Introduction: Within an International Atomic Energy Agency (IAEA) co-ordinated research project (CRP), a remote end-to-end dosimetric quality audit for intensity modulated radiation therapy (IMRT)/ volumetric arc therapy (VMAT) was developed to verify the radiotherapy chain including imaging, treatment planning and dose delivery. The methodology as well as the results obtained in a multicentre pilot study and national trial runs conducted in close cooperation with dosimetry audit networks (DANs) of IAEA Member States are presented.Material and methods: A solid polystyrene phantom containing a dosimetry insert with an irregular solid water planning target volume (PTV) and organ at risk (OAR) was designed for this audit. The insert can be preloaded with radiochromic film and four thermoluminescent dosimeters (TLDs). For the audit, radiotherapy centres were asked to scan the phantom, contour the structures, create an IMRT/VMAT treatment plan and irradiate the phantom. The dose prescription was to deliver 4 Gy to the PTV in two fractions and to limit the OAR dose to a maximum of 2.8 Gy. The TLD measured doses and film measured dose distributions were compared with the TPS calculations.Results: Sixteen hospitals from 13 countries and 64 hospitals from 6 countries participated in the multicenter pilot study and in the national runs, respectively. The TLD results for the PTV were all within ±5% acceptance limit for the multicentre pilot study, whereas for national runs, 17 participants failed to meet this criterion. All measured doses in the OAR were below the treatment planning constraint. The film analysis identified seven plans in national runs below the 90% passing rate gamma criteria.Conclusion: The results proved that the methodology of the IMRT/VMAT dosimetric end-to-end audit was feasible for its intended purpose, i.e., the phantom design and materials were suitable; the phantom was easy to use and it was robust enough for shipment. Most importantly the audit methodology was capable of identifying suboptimal IMRT/VMAT delivery.


Subject(s)
Medical Audit/methods , Organs at Risk , Phantoms, Imaging , Radiometry/methods , Radiotherapy Planning, Computer-Assisted/methods , Radiotherapy, Intensity-Modulated/methods , Feasibility Studies , Humans , International Agencies , Medical Audit/standards , Nuclear Energy , Pilot Projects , Quality Assurance, Health Care , Radiometry/standards , Radiotherapy Dosage , Radiotherapy, Intensity-Modulated/standards , Tomography, X-Ray Computed
3.
Pol J Radiol ; 82: 773-782, 2017.
Article in English | MEDLINE | ID: mdl-29657644

ABSTRACT

BACKGROUND: Regular quality control is required in Poland only for those methods of medical imaging which involve the use of ionizing radiation but not for ultrasonography. It is known that the quality of ultrasound images may be affected by the wearing down or malfunctioning of equipment. MATERIAL/METHODS: An evaluation of image quality was carried out for 22 ultrasound scanners equipped with 46 transducers. The CIRS Phantom model 040GSE was used. A set of tests was established which could be carried out with the phantom, including: depth of penetration, dead zone, distance measurement accuracy, resolution, uniformity, and visibility of structures. RESULTS: While the dead zone was 0 mm for 89% of transducers, it was 3 mm for the oldest transducer. The distances measured agreed with the actual distances by 1 mm or less in most cases, with the largest difference of 2.6 mm. The resolution in the axial direction for linear transducers did not exceed 1 mm, but it reached even 5 mm for some of the convex and sector transducers, especially at higher depths and in the lateral direction. For 29% of transducers, some distortions of anechoic structures were observed. Artifacts were detected for several transducers. CONCLUSIONS: The results will serve as a baseline for future testing. Several cases of suboptimal image quality were identified along with differences in performance between similar transducers. The results could be used to decide on the applicability of a given scanner or transducer for a particular kind of examination.

4.
Acta Oncol ; 55(7): 909-16, 2016 Jul.
Article in English | MEDLINE | ID: mdl-26934916

ABSTRACT

UNLABELLED: The International Atomic Energy Agency (IAEA) has a long tradition of supporting development of methodologies for national networks providing quality audits in radiotherapy. A series of co-ordinated research projects (CRPs) has been conducted by the IAEA since 1995 assisting national external audit groups developing national audit programs. The CRP 'Development of Quality Audits for Radiotherapy Dosimetry for Complex Treatment Techniques' was conducted in 2009-2012 as an extension of previously developed audit programs. MATERIAL AND METHODS: The CRP work described in this paper focused on developing and testing two steps of dosimetry audit: verification of heterogeneity corrections, and treatment planning system (TPS) modeling of small MLC fields, which are important for the initial stages of complex radiation treatments, such as IMRT. The project involved development of a new solid slab phantom with heterogeneities containing special measurement inserts for thermoluminescent dosimeters (TLD) and radiochromic films. The phantom and the audit methodology has been developed at the IAEA and tested in multi-center studies involving the CRP participants. RESULTS: The results of multi-center testing of methodology for two steps of dosimetry audit show that the design of audit procedures is adequate and the methodology is feasible for meeting the audit objectives. A total of 97% TLD results in heterogeneity situations obtained in the study were within 3% and all results within 5% agreement with the TPS predicted doses. In contrast, only 64% small beam profiles were within 3 mm agreement between the TPS calculated and film measured doses. Film dosimetry results have highlighted some limitations in TPS modeling of small beam profiles in the direction of MLC leave movements. DISCUSSION: Through multi-center testing, any challenges or difficulties in the proposed audit methodology were identified, and the methodology improved. Using the experience of these studies, the participants could incorporate the auditing procedures in their national programs.


Subject(s)
Radiometry/methods , Radiometry/standards , Radiotherapy Planning, Computer-Assisted/methods , Humans , International Agencies , Phantoms, Imaging , Quality Control , Radiation Dosimeters , Radiometry/instrumentation , Radiotherapy Planning, Computer-Assisted/standards , Thermoluminescent Dosimetry/instrumentation , Thermoluminescent Dosimetry/methods , Thermoluminescent Dosimetry/standards
5.
Phys Med Biol ; 69(3)2024 Jan 24.
Article in English | MEDLINE | ID: mdl-38091616

ABSTRACT

Objective. In this multicentric collaborative study, we aimed to verify whether the selected radiation detectors satisfy the requirements of TRS-483 Code of Practice for relative small field dosimetry in megavoltage photon beams used in radiotherapy, by investigating four dosimetric characteristics. Furthermore, we intended to analyze and complement the recommendations given in TRS-483.Approach. Short-term stability, dose linearity, dose-rate dependence, and leakage were determined for 17 models of detectors considered suitable for small field dosimetry. Altogether, 47 detectors were used in this study across ten institutions. Photon beams with 6 and 10 MV, with and without flattening filters, generated by Elekta Versa HDTMor Varian TrueBeamTMlinear accelerators, were used.Main results. The tolerance level of 0.1% for stability was fulfilled by 70% of the data points. For the determination of dose linearity, two methods were considered. Results from the use of a stricter method show that the guideline of 0.1% for dose linearity is not attainable for most of the detectors used in the study. Following the second approach (squared Pearson's correlation coefficientr2), it was found that 100% of the data fulfill the criteriar2> 0.999 (0.1% guideline for tolerance). Less than 50% of all data points satisfied the published tolerance of 0.1% for dose-rate dependence. Almost all data points (98.2%) satisfied the 0.1% criterion for leakage.Significance. For short-term stability (repeatability), it was found that the 0.1% guideline could not be met. Therefore, a less rigorous criterion of 0.25% is proposed. For dose linearity, our recommendation is to adopt a simple and clear methodology and to define an achievable tolerance based on the experimental data. For dose-rate dependence, a realistic criterion of 1% is proposed instead of the present 0.1%. Agreement was found with published guidelines for background signal (leakage).


Subject(s)
Particle Accelerators , Radiometry , Radiometry/methods , Photons
6.
Phys Med ; 116: 103168, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37984129

ABSTRACT

The dosimetry audit services were established in Poland in 1991, since then new audits have been introduced. The recently developed IAEA audit methodology for IMRT H&N treatments was tested nationally. Anthropomorphic SHANE phantom (CIRS) was used to perform measurements in 8 hospitals which voluntarily participated in the study. Each participant had to complete successfully pre-visit activities to take part in an onsite visit. During the visit, auditors together with the local staff, did a CT scan using local protocol, recalculated the plan and verified all the relevant parameters and performed measurements with an ionization chamber and films in SHANE. The adoption of IAEA methodology to the national circumstances was done with no major issues. Participants plans were verified and the results of ionization chamber were all within the 5 % tolerance limit for PTV (max 4,5%) and 7 % for OAR (max 5,3%). Film global gamma results (3 %, 3 mm, 90 % acceptance limit) were within 91,5-99,7% range. The IAEA established acceptance criteria which were achievable for most tests except for CTtoRED conversion curve. The locally performed study allowed establishing new limits. The audit gave interesting results and showed that the procedure is very thorough and capable to identify issues related with suboptimal treatment preparation and delivery. The new limits for CTtoRED conversion curve were adopted for national study. Such an audit gives an opportunity to verify the quality of locally implemented procedures and should be available for Polish hospitals on a daily basis.


Subject(s)
Radiotherapy Planning, Computer-Assisted , Radiotherapy, Intensity-Modulated , Humans , Radiotherapy Planning, Computer-Assisted/methods , Radiotherapy, Intensity-Modulated/methods , Poland , Radiometry/methods , Phantoms, Imaging , Radiotherapy Dosage
7.
Brachytherapy ; 21(4): 543-550, 2022.
Article in English | MEDLINE | ID: mdl-35514003

ABSTRACT

There are several accepted methods to verify External Beam Radiation Therapy (EBRT) treatment plans, but there is no standard way to check the quality of a brachytherapy treatment plan. PURPOSE: This feasibility study assesses whether the ArcCHECK EBRT radiation detector can also be used to verify Treatment Planning System software quality check procedures for brachytherapy. METHODS AND MATERIALS: ArcCHECK is a three-dimensional matrix of 1386 semiconductor diodes, arranged spirally around an internal cylindrical space that is 32 cm long and 15 cm in diameter. The detector makes it possible to reproduce the distribution of sources in a planned EBRT procedure (energy range 6-22 MeV) using an appropriate phantom. Detector responses are displayed as a two-dimensional dose distribution map on the diode surface. In this pilot brachytherapy study, we determined values that characterized the output of the detectors to a simulated Ir-192 radiation source with an energy range of approximately 9-1378 keV, and compared this to the actual signal recorded by an ArcCHECK detector. Experimental treatment plan measurement was performed using a standard Elekta micro-Selectron-v2 unit equipped with an iridium-192 source. To avoid unit inconsistencies, the signal from each of the diodes and the simulation results were normalized to the maximum value, with similar statistical parameters. RESULTS: The difference between diode indications in the simulation and the actual measurement was analyzed statistically to show the degree of general inconsistency between them. The average difference for diode pairs here is equal 1,07%, with standard deviation 3, 95%. CONCLUSION: The results obtained represent the first quantitative evidence of potential usefulness of the ArcCHECK detector in brachytherapy Treatment Planning System software QC verification.


Subject(s)
Brachytherapy , Brachytherapy/methods , Computer Simulation , Humans , Monte Carlo Method , Phantoms, Imaging , Radiometry/methods , Radiotherapy Dosage
8.
Appl Radiat Isot ; 184: 110198, 2022 Jun.
Article in English | MEDLINE | ID: mdl-35313266

ABSTRACT

Periodic intermediate checks on the equipment used for calibration activity accredited for the conformity with the international norm ISO/IEC 17025 are an essential issue for monitoring the validity of calibration laboratory's results. These checks should be carried out according to a procedure defined by each accredited laboratory. The results of these checks should not exceed the acceptance criteria established in the laboratory and statistical techniques shall be applied to the reviewing of the results. In this work, a simple method of carrying out intermediate checks on working standards used for calibrations of ionizing radiation dosimeters in a 60Co gamma ray beam was presented. Moreover, the statistical analysis of obtained results was presented. This analysis allowed for a reliable inference regarding the operation of the working standards used to calibrate the customer's devices. The presented methods can be used as a guidance in order to conform to the ISO/IEC 17025 requirements for carrying out and reviewing of periodic intermediate checks results in the area of calibrations of ionizing radiation dosimeters for external beam radiotherapy.


Subject(s)
Laboratories , Radiation Dosimeters , Calibration , Gamma Rays
9.
Strahlenther Onkol ; 186(6): 327-33, 2010 Jun.
Article in English | MEDLINE | ID: mdl-20458451

ABSTRACT

PURPOSE: To evaluate the performance of computed tomography (CT) systems of various designs as a source of electron density (rho(el)) data for treatment planning of radiation therapy. MATERIAL AND METHODS: Dependence of CT numbers on relative electron density of tissue-equivalent materials (HU-rho(el) relationship) was measured for several general-purpose CT systems (single-slice, multislice, wide-bore multislice), for radiotherapy simulators with a single-slice CT and kV CBCT (cone-beam CT) options, as well as for linear accelerators with kV and MV CBCT systems. Electron density phantoms of four sizes were used. Measurement data were compared with the standard HU-rhoel relationships predefined in two commercial treatment-planning systems (TPS). RESULTS: The HU-rho(el) relationships obtained with all of the general-purpose CT scanners operating at voltages close to 120 kV were very similar to each other and close to those predefined in TPS. Some dependency of HU values on tube voltage was observed for bone- equivalent materials. For a given tube voltage, differences in results obtained for different phantoms were larger than those obtained for different CT scanners. For radiotherapy simulators and for kV CBCT systems, the information on rhoel was much less precise because of poor uniformity of images. For MV CBCT, the results were significantly different than for kV systems due to the differing energy spectrum of the beam. CONCLUSION: The HU-rho(el) relationships predefined in TPS can be used for general-purpose CT systems operating at voltages close to 120 kV. For nontypical imaging systems (e.g., CBCT), the relationship can be significantly different and, therefore, it should always be measured and carefully analyzed before using CT data for treatment planning.


Subject(s)
Cone-Beam Computed Tomography/methods , Electrons , Image Processing, Computer-Assisted/instrumentation , Image Processing, Computer-Assisted/methods , Radiotherapy Planning, Computer-Assisted/methods , Tomography, X-Ray Computed/methods , Cone-Beam Computed Tomography/instrumentation , Humans , Particle Accelerators , Phantoms, Imaging , Radiotherapy Planning, Computer-Assisted/instrumentation , Tomography, X-Ray Computed/instrumentation
10.
Rep Pract Oncol Radiother ; 15(6): 155-60, 2010.
Article in English | MEDLINE | ID: mdl-24376942

ABSTRACT

AIM: The purpose of this study was to examine the usefulness of using Simultaneous Integrated Boost (SIB) radiotherapy for thyroid cancer treatment. BACKGROUND: At our hospital a 3D Conformal RadioTherapy (3D-CRT) technique involving photon and electron beams for the treatment of thyroid cancer was often used.(1) High dose to the spinal canal was limiting the total dose of such a treatment. After investigation of Intensity Modulated Radiotherapy (IMRT) technique involving seven photon beams for first course of treatment(3) we decided to examine possibility of reducing treatment fractions by using SIB radiotherapy. MATERIAL AND METHODS: Plans for 10 patients were studied. For each patient, IMRT plan for the first course of treatment (50 Gy for PTV), two plans for the second course of treatment (10 Gy for BOOST) and a SIB plan (50 Gy for PTV, 56 Gy for BOOST) were prepared. For all plans, comparisons of dose statistics for the PTV, BOOST, PTV without BOOST (defined as PTV without BOOST with 1 cm margin), spinal canal and Patient Outline (Body) was done. RESULTS: Minimum dose for BOOST is higher in the SIB technique than in the two course treatment. PTV without BOOST receives the same average dose in SIB and the 1st course IMRT - 50.10 Gy and 49.84 Gy, respectively. In the SIB technique, higher reduction of dose delivered to the spinal canal is possible (27 Gy compared with 30 Gy). CONCLUSION: SIB therapy for thyroid cancer with relation to typical two course treatment is a good proposal of reducing the number of fractions with the same dose for BOOST and PTV without BOOST. Additionally, better sparing of the spinal canal is achieved.

11.
Rep Pract Oncol Radiother ; 15(2): 40-6, 2010.
Article in English | MEDLINE | ID: mdl-24376922

ABSTRACT

AIM: The purpose of the study was to examine the energy dependence of Gafchromic EBT radiochromic dosimetry films, in order to assess their potential use in intensity-modulated radiotherapy (IMRT) verifications. MATERIALS AND METHODS: The film samples were irradiated with doses from 0.1 to 12 Gy using photon beams from the energy range 1.25 MeV to 25 MV and the film response was measured using a flat-bed scanner. The samples were scanned and the film responses for different beam energies were compared. RESULTS: A high uncertainty in readout of the film response was observed for samples irradiated with doses lower than 1 Gy. The relative difference exceeds 20% for doses lower than 1 Gy while for doses over 1 Gy the measured film response differs by less than 5% for the whole examined energy range. The achieved uncertainty of the experimental procedure does not reveal any energy dependence of Gafchromic EBT film response in the investigated energy range. CONCLUSIONS: Gafchromic EBT film does not show any energy dependence in the conditions typical for IMRT but the doses measured for pre-treatment plan verifications should exceed 1 Gy.

12.
Cardiovasc Revasc Med ; 9(3): 149-55, 2008.
Article in English | MEDLINE | ID: mdl-18606378

ABSTRACT

BACKGROUND: Restenosis is the complete occlusion of the blood vessel leading to such complications as ischemia/angina, myocardial infarction, and death. It can be managed by endovascular brachytherapy with both gamma and beta sources. Endovascular brachytherapy is performed worldwide on several thousands of cases per year. The gamma-emitter 192Ir as well as the beta-emitters 32P and 90Sr are mainly used. The dose to the occluded endothelial wall is 20 Gy. Interestingly, no information with respect to the dose absorbed by the blood during the course of the treatment exists. The aim of the present investigation was to verify if the micronucleus test is suitable to detect the dose absorbed by lymphocytes in the course of endovascular brachytherapy with 32P. MATERIALS AND METHODS: Blood was drawn from 16 patients immediately before and 1 day after the treatment. Frequencies of micronuclei were assessed. In order to ensure that the micronuclei did not arise due to fluoroscopy or reperfusion, we analyzed lymphocytes of 16 control patients who underwent interventional cardiology with balloon angioplasty only. RESULTS AND CONCLUSIONS: Enhanced frequencies of micronuclei were observed in lymphocytes of some donors following brachytherapy. No correlation could be detected between the level of induced micronuclei and the absorbed dose. Also, no effect of fluoroscopy or reperfusion was seen. Thus, although brachytherapy of restenosis with 32P leads to weak enhancement of the micronucleus frequency in lymphocytes, the effect was not seen in all patients; the reason for this heterogeneous response remains to be elucidated.


Subject(s)
Angioplasty, Balloon, Coronary/methods , Brachytherapy/methods , Coronary Restenosis/radiotherapy , Lymphocytes/ultrastructure , Micronucleus, Germline/radiation effects , Cells, Cultured , Coronary Restenosis/blood , Follow-Up Studies , Humans , Lymphocytes/radiation effects , Micronucleus, Germline/ultrastructure , Treatment Outcome
13.
Phys Imaging Radiat Oncol ; 6: 1-4, 2018 Apr.
Article in English | MEDLINE | ID: mdl-33458380

ABSTRACT

An audit methodology was developed and applied for output factor (OF) calculations in radiotherapy. The auditees were asked to calculate OFs for field sizes from 10 × 10 cm2 to 2 × 2 cm2. Sixty five beams were audited; missing reference OFs were interpolated. The calculated OFs were in 73% of cases higher than the reference data. The smaller the field size, the higher the overestimations which were observed in the higher fraction of cases. Treatment planning systems generally overestimated OFs for small fields. The reference dataset helped radiotherapy centres to identify discrepancies which were higher than typical.

14.
Phys Imaging Radiat Oncol ; 5: 58-63, 2018 Jan.
Article in English | MEDLINE | ID: mdl-33458370

ABSTRACT

BACKGROUND AND PURPOSE: An audit methodology for verifying the implementation of output factors (OFs) of small fields in treatment planning systems (TPSs) used in radiotherapy was developed and tested through a multinational research group and performed on a national level in five different countries. MATERIALS AND METHODS: Centres participating in this study were asked to provide OFs calculated by their TPSs for 10 × 10 cm2, 6 × 6 cm2, 4 × 4 cm2, 3 × 3 cm2 and 2 × 2 cm2 field sizes using an SSD of 100 cm. The ratio of these calculated OFs to reference OFs was analysed. The action limit was ±3% for the 2 × 2 cm2 field and ±2% for all other fields. RESULTS: OFs for more than 200 different beams were collected in total. On average, the OFs for small fields calculated by TPSs were generally larger than measured reference data. These deviations increased with decreasing field size. On a national level, 30% and 31% of the calculated OFs of the 2 × 2 cm2 field exceeded the action limit of 3% for nominal beam energies of 6 MV and for nominal beam energies higher than 6 MV, respectively. CONCLUSION: Modern TPS beam models generally overestimate the OFs for small fields. The verification of calculated small field OFs is a vital step and should be included when commissioning a TPS. The methodology outlined in this study can be used to identify potential discrepancies in clinical beam models.

15.
Radiother Oncol ; 84(1): 67-74, 2007 Jul.
Article in English | MEDLINE | ID: mdl-17628209

ABSTRACT

BACKGROUND AND PURPOSE: A strategy for national TLD audit programmes has been developed by the International Atomic Energy Agency (IAEA). It involves progression through three sequential dosimetry audit steps. The first step audits are for the beam output in reference conditions for high-energy photon beams. The second step audits are for the dose in reference and non-reference conditions on the beam axis for photon and electron beams. The third step audits involve measurements of the dose in reference, and non-reference conditions off-axis for open and wedged symmetric and asymmetric fields for photon beams. Through a co-ordinated research project the IAEA developed the methodology to extend the scope of national TLD auditing activities to more complex audit measurements for regular fields. MATERIALS AND METHODS: Based on the IAEA standard TLD holder for high-energy photon beams, a TLD holder was developed with horizontal arm to enable measurements 5cm off the central axis. Basic correction factors were determined for the holder in the energy range between Co-60 and 25MV photon beams. RESULTS: New procedures were developed for the TLD irradiation in hospitals. The off-axis measurement methodology for photon beams was tested in a multi-national pilot study. The statistical distribution of dosimetric parameters (off-axis ratios for open and wedge beam profiles, output factors, wedge transmission factors) checked in 146 measurements was 0.999+/-0.012. CONCLUSIONS: The methodology of TLD audits in non-reference conditions with a modified IAEA TLD holder has been shown to be feasible.


Subject(s)
Radiotherapy, High-Energy/standards , Thermoluminescent Dosimetry/standards , Feasibility Studies , Humans , International Agencies , Medical Audit , Photons , Pilot Projects , Quality Control , Radiometry , Radiotherapy Dosage/standards , Reference Standards , Reproducibility of Results
17.
Int J Cardiol ; 107(2): 247-53, 2006 Feb 15.
Article in English | MEDLINE | ID: mdl-16412805

ABSTRACT

UNLABELLED: It is unknown whether model of renarrowing after beta-radiation for in-stent restenosis (ISR) is influenced by the type of geographic miss (GM). METHODS: In 166 ISR treated with Galileo, serial quantitative coronary angiographic analysis was done. Minimal lumen diameters and lengths were measured for (1) stent, (2) peri-stent subsegments subjected to angioplasty with/without irradiation, and (3) irradiation margins. GM was defined as: (Type 1) edge injury within the 32P source dose fall-off: 2.0 mm inside and outside the source end marker or (Type 2) overt, nonirradiated injury: beyond the outer 2.0-mm long dose fall-off zone. RESULTS: Restenosis rate was 28.3% at 8.9+/-4.5 months with 60% located exclusively outside the stent. Type 1 GM was present in 24.7% of proximal edges, whereas Type 2 in 18.1%. Respective percentages for distal edges were 23.5% and 15.7%. Regardless of presence and type of GM, significant late lumen loss occurred only outside the stent. However, the biggest late lumen loss at the proximal edge was induced by the Type 1 GM (0.65+/-0.79, p<0.001), while proximal Type 2 GM was not associated with edge renarrowing (-0.04+/-0.48, p=NS). Both reference lumen diameter and proximal Type 1 GM influenced restenosis independently (OR 0.47; 95%CI 0.24-0.90; p=0.023 and OR 2.46; 95%CI 1.12-5.40; p=0.025). CONCLUSIONS: Regardless of presence and type of geographic miss, late lumen loss after beta-radiation occurs only outside the stent. However, injury within the proximal 32P dose fall-off but not overt edge injury is associated with the biggest late lumen loss at the respective edge, triggering recurrent restenosis.


Subject(s)
Beta Particles/therapeutic use , Coronary Restenosis/pathology , Coronary Restenosis/radiotherapy , Stents , Aged , Blood Vessel Prosthesis Implantation , Coronary Angiography , Coronary Restenosis/diagnostic imaging , Coronary Restenosis/etiology , Dose-Response Relationship, Radiation , Female , Follow-Up Studies , Humans , Male , Middle Aged , Phosphorus Radioisotopes/therapeutic use , Predictive Value of Tests , Radiotherapy Dosage , Treatment Outcome
18.
Cardiovasc Revasc Med ; 7(4): 202-7, 2006.
Article in English | MEDLINE | ID: mdl-17174864

ABSTRACT

BACKGROUND: The aim of our study was to test the impact of acute lumen overdilation on neointimal hyperplasia and late lumen size after vascular brachytherapy for in-stent restenosis (ISR). METHODS: Forty-seven ISR lesions located in 47 coronary arteries in 44 consecutive patients underwent beta brachytherapy with serial intravascular ultrasound studies. Vessel, lumen, and stent cross-sectional area were measured at 1-mm steps. Based on an interpolated reference cross-sectional area, each cross section was assessed as overdilated (lumen cross-sectional area>interpolated reference cross-sectional area) or not overdilated (lumen cross-sectional area

Subject(s)
Brachytherapy/methods , Coronary Restenosis/radiotherapy , Stents , Tunica Intima/radiation effects , Angioplasty, Balloon , Coronary Angiography , Coronary Restenosis/diagnostic imaging , Coronary Restenosis/therapy , Dilatation, Pathologic , Female , Humans , Hyperplasia , Linear Models , Male , Middle Aged , Recurrence , Retrospective Studies , Treatment Outcome , Tunica Intima/diagnostic imaging , Tunica Intima/pathology , Ultrasonography, Interventional
19.
Cardiovasc Revasc Med ; 7(1): 34-40, 2006.
Article in English | MEDLINE | ID: mdl-16513521

ABSTRACT

AIM: The incidence of restenosis within stented segment after intravascular brachytherapy with recommended dose prescription protocols is up to 25%. Therefore, we designed a randomized trial comparing recommended dose prescription protocol with dosing adjusted for the source-to-target distance. METHODS: Fifty-one in-stent restenosis (ISR) lesions in 48 patients underwent centered source beta-irradiation with serial intravascular ultrasound. Patients randomly received 20 Gy at 1 mm either beyond lumen surface [n=25, standard group (S)] or external elastic membrane [n=26, dosing-adjusted (DA) group]. Minimum dose absorbed by 90% of adventitia (DV(90%Adv)) was calculated. RESULTS: DV(90%Adv) was higher for the DA group than for the S group (21.63+/-5.67 vs. 12.05+/-4.88 Gy, P<.001). After 8.9+/-4.5 months there was complete lumen preservation in DA vs. lumen decrease subsequent to neointimal hyperplasia (NIH) in S group (0.10+/-1.20 vs. -0.61+/-1.29 mm3/mm, P<.05). Vessel volume increased significantly in the DA group and was unchanged in S group (+1.73, P=.002 vs. 0.14 mm3/mm, P=NS). DV(90%Adv) correlated inversely with NIH volume and positively with vessel volume change (r=-.405, P=.007 and r=.363, P=.017, respectively). CONCLUSION: For beta-irradiation of ISR, dosing adjusted for the source-to-target distance leads to significant increase in target delivered doses, which is associated with complete NIH inhibition and induction of positive vessel remodeling.


Subject(s)
Brachytherapy/methods , Coronary Restenosis/radiotherapy , Chi-Square Distribution , Coronary Angiography , Coronary Restenosis/diagnostic imaging , Female , Humans , Linear Models , Male , Middle Aged , Prospective Studies , Radiotherapy Dosage , Statistics, Nonparametric , Stents , Ultrasonography, Interventional
20.
Phys Med ; 32(7): 914-7, 2016 Jul.
Article in English | MEDLINE | ID: mdl-27378393

ABSTRACT

This paper presents the situation of the profession of medical physicists in Poland. The official recognition of the profession of medical physicist in Polish legislation was in 2002. In recent years, more and more Universities which have Physics Faculties introduce a medical physics specialty. At present, there are about 15 Universities which offer such programmes. These Universities are able to graduate about 150 medical physicists per year. In 2002, the Ministry of Health introduced a programme of postgraduate specialization in medical physics along the same rules employed in the specialization of physicians in various branches of medicine. Five institutions, mostly large oncology centres, were selected as teaching institutions, based on their experience, the quality of the medical physics professionals, staffing levels, equipment availability, lecture halls, etc. The first cycle of the specialization programme started in 2006, and the first candidates completed their training at the end of 2008, and passed their official state exams in May 2009. As of January 2016, there are 196 specialized medical physicists in Poland. Another about 120 medical physicists are undergoing specialization. The system of training of medical physics professionals in Poland is well established. The principles of postgraduate training and specialization are well defined and the curriculum of the training is very demanding. The programme of specialization was revised in 2011 and is in accordance with EC and EFOMP recommendations.


Subject(s)
Health Physics/education , Specialization/statistics & numerical data , Poland
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