1.
J Pediatr Hematol Oncol
; 38(6): e191-2, 2016 08.
Article
in English
| MEDLINE
| ID: mdl-27322716
ABSTRACT
A male preterm infant was born with dysmorphic features consistent with Rubinstein-Taybi syndrome (RTS). An undescended right testicle was noted on examination. At 5 months of age he developed a palpable right-sided abdominal mass and an elevated alpha-fetoprotein. Histology revealed a malignant germ cell neoplasm arising within the undescended testis. This is the first reported case of a germ cell tumor occurring in a pediatric patient with RTS. Urologic abnormalities occur in approximately 52% of RTS patients, of which cryptorchidism is the commonest. Given the frequency of undescended testes in this population, closer screening may be warranted.
Subject(s)
Cryptorchidism/complications , Neoplasms, Germ Cell and Embryonal/pathology , Rubinstein-Taybi Syndrome/complications , Testicular Neoplasms/pathology , Humans , Infant , Male , Neoplasms, Germ Cell and Embryonal/surgery , Testicular Neoplasms/surgery
2.
Br J Haematol
; 178(1): 152-153, 2017 07.
Article
in English
| MEDLINE
| ID: mdl-27102370