ABSTRACT
This study was undertaken to investigate the possible genetic association of functional CTLA4 polymorphisms with susceptibility to non-anterior uveitis. Four hundred and seventeen patients with endogenous non-anterior uveitis and 1517 healthy controls of Spanish Caucasian origin were genotyped for the CTLA4 polymorphisms rs733618, rs5742909 and rs231775, using predesigned TaqMan(©) allele discrimination assays. PLINK software was used for the statistical analyses. No significant associations between the CTLA4 polymorphisms and susceptibility to global non-anterior uveitis were found. It was also the case when the potential association of these genetic variants with the anatomical localization of the disease, such as intermediate, posterior or panuveitis, was assessed. Our results do not support a relevant role of these CTLA4 polymorphisms in the non-anterior uveitis genetic predisposition.
Subject(s)
Genetic Predisposition to Disease , Polymorphism, Genetic , Uveitis/genetics , Adult , CTLA-4 Antigen , Female , Humans , Male , Spain , White PeopleABSTRACT
CASE REPORT: A 68 year-old male with idiopathic choroidal polypoidal vasculopathy received seven intravitreal injections of bevacizumab in the supero-nasal quadrant. He later developed a localized limbal stem cell deficiency which required limbal transplantation from the same eye. Two months after surgery, a slight improvement of visual acuity was noted, along with an intact ocular surface, clear cornea and decreased inflammation. DISCUSSION: Repeated surgical trauma on the limbus and surrounding areas may damage the limbal stem cells, giving rise to a corneal epitheliopathy due to iatrogenic limbal deficiency. Repeated intravitreal injections may be considered as one of the possible causes.
Subject(s)
Angiogenesis Inhibitors/administration & dosage , Antibodies, Monoclonal/administration & dosage , Choroidal Neovascularization/drug therapy , Corneal Diseases/etiology , Epithelium, Corneal/pathology , Intravitreal Injections/adverse effects , Limbus Corneae/injuries , Stem Cells/pathology , Aged , Angiogenesis Inhibitors/therapeutic use , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Humanized , Bevacizumab , Combined Modality Therapy , Corneal Diseases/pathology , Corneal Diseases/surgery , Corneal Transplantation , Epithelium, Corneal/diagnostic imaging , Humans , Limbus Corneae/pathology , Male , Microscopy, Acoustic , Phototherapy , Transplantation, AutologousABSTRACT
PURPOSE: To analyse and quantitatively compare the outcomes of microincisional cataract surgery (CCMIC) with those of conventional phacoemulsification, evaluating the induced astigmatism, endothelial cell count, corneal thickness and foveal thickness in the pre- and postoperative period. METHODS: Prospective and randomised study, including 74 eyes of 37 patients with a mean age of 72.97±7.55 years. All of them underwent conventional phacoemulsification in one eye and CCMIC in the other eye. The evaluated parameters were refractive and topographic astigmatism, endothelial cell count, corneal thickness and foveal thickness, which were measured preoperatively and at 1 day, 1 week, 1 month and 3 months after surgery. RESULTS: The variations between pre- and postoperative parameters showed no statistically significant differences between the two surgical procedures (p>0.05). CONCLUSIONS: CCMIC is an effective and safe technique that offers an excellent alternative for cataract surgery, with a smaller incision and postoperative outcomes comparable to the standard technique. Prospective studies with more patients and longer follow-ups are needed to establish if there really are statistically significant and clinically relevant differences between both techniques.