Search | Virtual Health Library

1.

Architecture of the outbred brown fat proteome defines regulators of metabolic physiology.

Xiao, Haopeng; Bozi, Luiz H M; Sun, Yizhi; Riley, Christopher L; Philip, Vivek M; Chen, Mandy; Li, Jiaming; Zhang, Tian; Mills, Evanna L; Emont, Margo P; Sun, Wenfei; Reddy, Anita; Garrity, Ryan; Long, Jiani; Becher, Tobias; Vitas, Laura Potano; Laznik-Bogoslavski, Dina; Ordonez, Martha; Liu, Xinyue; Chen, Xiong; Wang, Yun; Liu, Weihai; Tran, Nhien; Liu, Yitong; Zhang, Yang; Cypess, Aaron M; White, Andrew P; He, Yuchen; Deng, Rebecca; Schöder, Heiko; Paulo, Joao A; Jedrychowski, Mark P; Banks, Alexander S; Tseng, Yu-Hua; Cohen, Paul; Tsai, Linus T; Rosen, Evan D; Klein, Samuel; Chondronikola, Maria; McAllister, Fiona E; Van Bruggen, Nick; Huttlin, Edward L; Spiegelman, Bruce M; Churchill, Gary A; Gygi, Steven P; Chouchani, Edward T.

Cell ; 185(24): 4654-4673.e28, 2022 11 23.

Article in English | MEDLINE | ID: mdl-36334589

2.

IRF4 is a key thermogenic transcriptional partner of PGC-1α.

Kong, Xingxing; Banks, Alexander; Liu, Tiemin; Kazak, Lawrence; Rao, Rajesh R; Cohen, Paul; Wang, Xun; Yu, Songtao; Lo, James C; Tseng, Yu-Hua; Cypess, Aaron M; Xue, Ruidan; Kleiner, Sandra; Kang, Sona; Spiegelman, Bruce M; Rosen, Evan D.

Cell ; 158(1): 69-83, 2014 Jul 03.

Article in English | MEDLINE | ID: mdl-24995979

3.

The thermoneutral zone in women takes an "arctic" shift compared to men.

Brychta, Robert J; McGehee, Suzanne; Huang, Shan; Leitner, Brooks P; Duckworth, Courtney J; Fletcher, Laura A; Kim, Katherine; Cassimatis, Thomas M; Israni, Nikita S; Lea, Hannah J; Lentz, Taylor N; Pierce, Anne E; Jiang, Alex; LaMunion, Samuel R; Thomas, Reed J; Ishihara, Asuka; Courville, Amber B; Yang, Shanna B; Reitman, Marc L; Cypess, Aaron M; Chen, Kong Y.

Proc Natl Acad Sci U S A ; 121(19): e2311116121, 2024 May 07.

Article in English | MEDLINE | ID: mdl-38683977

4.

Characterization of transcript enrichment and detection bias in single-nucleus RNA-seq for mapping of distinct human adipocyte lineages.

Gupta, Anushka; Shamsi, Farnaz; Altemose, Nicolas; Dorlhiac, Gabriel F; Cypess, Aaron M; White, Andrew P; Yosef, Nir; Patti, Mary Elizabeth; Tseng, Yu-Hua; Streets, Aaron.

Genome Res ; 32(2): 242-257, 2022 02.

Article in English | MEDLINE | ID: mdl-35042723

5.

Opportunities and challenges in the therapeutic activation of human energy expenditure and thermogenesis to manage obesity.

Chen, Kong Y; Brychta, Robert J; Abdul Sater, Zahraa; Cassimatis, Thomas M; Cero, Cheryl; Fletcher, Laura A; Israni, Nikita S; Johnson, James W; Lea, Hannah J; Linderman, Joyce D; O'Mara, Alana E; Zhu, Kenneth Y; Cypess, Aaron M.

J Biol Chem ; 295(7): 1926-1942, 2020 02 14.

Article in English | MEDLINE | ID: mdl-31914415

6.

Proton MR Spectroscopy Measurements of White and Brown Adipose Tissue in Healthy Humans: Relaxation Parameters and Unsaturated Fatty Acids.

Ouwerkerk, Ronald; Hamimi, Ahmed; Matta, Jatin; Abd-Elmoniem, Khaled Z; Eary, Janet F; Abdul Sater, Zahraa; Chen, Kong Y; Cypess, Aaron M; Gharib, Ahmed M.

Radiology ; 299(2): 396-406, 2021 05.

Article in English | MEDLINE | ID: mdl-33724063

7.

Reassessing Human Adipose Tissue.

Cypess, Aaron M.

N Engl J Med ; 386(8): 768-779, 2022 02 24.

Article in English | MEDLINE | ID: mdl-35196429

8.

Reassessing Human Adipose Tissue. Reply.

Cypess, Aaron M.

N Engl J Med ; 386(22): e61, 2022 06 02.

Article in English | MEDLINE | ID: mdl-35648728

9.

Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis.

Chouinard, Virginie-Anne; Henderson, David C; Dalla Man, Chiara; Valeri, Linda; Gray, Brianna E; Ryan, Kyle P; Cypess, Aaron M; Cobelli, Claudio; Cohen, Bruce M; Öngür, Dost.

Mol Psychiatry ; 24(10): 1513-1522, 2019 10.

Article in English | MEDLINE | ID: mdl-29523870

10.

Mapping of human brown adipose tissue in lean and obese young men.

Leitner, Brooks P; Huang, Shan; Brychta, Robert J; Duckworth, Courtney J; Baskin, Alison S; McGehee, Suzanne; Tal, Ilan; Dieckmann, William; Gupta, Garima; Kolodny, Gerald M; Pacak, Karel; Herscovitch, Peter; Cypess, Aaron M; Chen, Kong Y.

Proc Natl Acad Sci U S A ; 114(32): 8649-8654, 2017 08 08.

Article in English | MEDLINE | ID: mdl-28739898

11.

Kinetics of human brown adipose tissue activation and deactivation.

Leitner, Brooks P; Weiner, Lauren S; Desir, Matthew; Kahn, Peter A; Selen, Daryl J; Tsang, Cathy; Kolodny, Gerald M; Cypess, Aaron M.

Int J Obes (Lond) ; 43(3): 633-637, 2019 03.

Article in English | MEDLINE | ID: mdl-29795459

12.

Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat.

Schulz, Tim J; Huang, Ping; Huang, Tian Lian; Xue, Ruidan; McDougall, Lindsay E; Townsend, Kristy L; Cypess, Aaron M; Mishina, Yuji; Gussoni, Emanuela; Tseng, Yu-Hua.

Nature ; 495(7441): 379-83, 2013 Mar 21.

Article in English | MEDLINE | ID: mdl-23485971

13.

MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network.

Zhang, Hongbin; Guan, Meiping; Townsend, Kristy L; Huang, Tian Lian; An, Ding; Yan, Xu; Xue, Ruidan; Schulz, Tim J; Winnay, Jonathon; Mori, Marcelo; Hirshman, Michael F; Kristiansen, Karsten; Tsang, John S; White, Andrew P; Cypess, Aaron M; Goodyear, Laurie J; Tseng, Yu-Hua.

EMBO Rep ; 16(10): 1378-93, 2015 Oct.

Article in English | MEDLINE | ID: mdl-26303948

14.

Imaging of Brown Adipose Tissue: State of the Art.

Sampath, Srihari C; Sampath, Srinath C; Bredella, Miriam A; Cypess, Aaron M; Torriani, Martin.

Radiology ; 280(1): 4-19, 2016 07.

Article in English | MEDLINE | ID: mdl-27322970

15.

Effects of lifestyle modification and metformin on irisin and FGF21 among HIV-infected subjects with the metabolic syndrome.

Srinivasa, Suman; Wong, Kimberly; Fitch, Kathleen V; Wei, Jeffrey; Petrow, Eva; Cypess, Aaron M; Torriani, Martin; Grinspoon, Steven K.

Clin Endocrinol (Oxf) ; 82(5): 678-85, 2015 May.

Article in English | MEDLINE | ID: mdl-25130061

16.

Cold but not sympathomimetics activates human brown adipose tissue in vivo.

Cypess, Aaron M; Chen, Yih-Chieh; Sze, Cathy; Wang, Ke; English, Jeffrey; Chan, Onyee; Holman, Ashley R; Tal, Ilan; Palmer, Matthew R; Kolodny, Gerald M; Kahn, C Ronald.

Proc Natl Acad Sci U S A ; 109(25): 10001-5, 2012 Jun 19.

Article in English | MEDLINE | ID: mdl-22665804

17.

Reply to Letter to the Editor: "No insulating effect of obesity, neither in mice nor in humans".

Brychta, Robert J; Cypess, Aaron M; Reitman, Marc L; Chen, Kong Y.

Am J Physiol Endocrinol Metab ; 317(5): E954-E956, 2019 11 01.

Article in English | MEDLINE | ID: mdl-31697208

18.

Brown adipose tissue activation in humans increases plasma levels of lipid mediators.

Walker, Mary E; Kodani, Sean D; Mena, Hebe Agustina; Tseng, Yu-Hua; Cypess, Aaron M; Spite, Matthew.

J Clin Endocrinol Metab ; 2024 Jan 10.

Article in English | MEDLINE | ID: mdl-38198796

19.

Insulin enhances glucose-stimulated insulin secretion in healthy humans.

Bouche, Clara; Lopez, Ximena; Fleischman, Amy; Cypess, Aaron M; O'Shea, Sheila; Stefanovski, Darko; Bergman, Richard N; Rogatsky, Eduard; Stein, Daniel T; Kahn, C Ronald; Kulkarni, Rohit N; Goldfine, Allison B.

Proc Natl Acad Sci U S A ; 107(10): 4770-5, 2010 Mar 09.

Article in English | MEDLINE | ID: mdl-20176932

20.

Standardized In Vitro Models of Human Adipose Tissue Reveal Metabolic Flexibility in Brown Adipocyte Thermogenesis.

Cero, Cheryl; Shu, Weiguo; Reese, Amy L; Douglas, Diana; Maddox, Michael; Singh, Ajeet P; Ali, Sahara L; Zhu, Alexander R; Katz, Jacqueline M; Pierce, Anne E; Long, Kelly T; Nilubol, Naris; Cypess, Raymond H; Jacobs, Jonathan L; Tian, Fang; Cypess, Aaron M.

Endocrinology ; 164(12)2023 Nov 02.

Article in English | MEDLINE | ID: mdl-37944134

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