ABSTRACT
A 19-year-old woman had an extensive nevus comedonicus affecting the left arm, trunk, and leg. Her condition was complicated by episodes of recurrent cyst formation and secondary infection. These were reduced in extent and frequency during 14 months of treatment with a combined progesterone-estrogen contraceptive preparation, and the appearance of the lesions affecting the leg was improved. The clinical features, histogenesis, histology, and treatment of nevus comedonicus are discussed.
Subject(s)
Nevus/pathology , Skin Neoplasms/pathology , Adolescent , Adult , Contraceptives, Oral, Hormonal/therapeutic use , Cysts/etiology , Female , Hair Diseases/complications , Hair Diseases/pathology , Hair Diseases/therapy , Humans , Nevus/complications , Nevus/therapy , Skin Diseases/etiology , Skin Diseases, Infectious/etiology , Skin Neoplasms/complications , Skin Neoplasms/therapyABSTRACT
Several years after postmastectomy radiation therapy, lichen sclerosus et atrophicus (LSA) developed in two patients within the radiation fields. This sequence, to our knowledge, has not previously been described. The etiology of LSA is largely unknown, but trauma has been implicated as a provoking factor in some cases, and LSA might be an isomorphic response to the trauma of radiation therapy.
Subject(s)
Radiotherapy/adverse effects , Skin Diseases/etiology , Atrophy , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Chronic Disease , Female , Humans , Mastectomy , Middle Aged , Skin/ultrastructure , Skin Diseases/pathologySubject(s)
Angiokeratoma/complications , Fingers , Necrosis/complications , Skin Neoplasms/complications , Angiokeratoma/blood , Angiokeratoma/drug therapy , Angiokeratoma/pathology , Blood Proteins/analysis , Child , Female , Frostbite , Humans , Immunoglobulin A/analysis , Immunoglobulin G/analysis , Immunoglobulin M/analysis , Intellectual Disability , Mouth Diseases/complications , Muscle Spasticity/complications , Prednisolone/therapeutic use , Skin Neoplasms/blood , Skin Neoplasms/drug therapy , Skin Neoplasms/pathology , Syndrome , Triamcinolone Acetonide/therapeutic use , Ulcer/complicationsABSTRACT
Application of dithranol confined to the normal skin surrounding thirty-six psoriatic lesions produced improvement in twenty-four lesions, which was significantly more than the improvement noted in four of thirty-six control lesions left untreated. Such healing was temporary and slower than in lesions treated conventionally. It is suggested that the apparently normal skin around a psoriatic lesion under treatment influences the psoriasis.
Subject(s)
Anthracenes/therapeutic use , Anthralin/therapeutic use , Psoriasis/drug therapy , Administration, Topical , Adolescent , Adult , Aged , Anthralin/administration & dosage , Clinical Trials as Topic , Female , Humans , Male , Middle Aged , RecurrenceABSTRACT
Twelve women in the home help service in Nottingham developed dermatitis after using enzyme detergents. A survey based on a questionary showed an incidence of 5% among those using them. The enzyme appears to act as a primary irritant.
Subject(s)
Dermatitis, Contact/etiology , Detergents/adverse effects , Enzymes/adverse effects , Occupational Diseases , Adult , Female , Humans , Middle Aged , Skin TestsABSTRACT
A case of multicentric pigmented Bowen's disease in a 45 year old woman with a previous history of carcinoma of the cervix is described. The two conditions may have a common pathogenesis, and a preceding viral infection with herpes simplex or human papillomavirus could be of aetiological relevance. Patients with multicentric pigmented Bowen's disease may be at risk of developing other tumours of the genital tract. Treatment with carbon dioxide laser proved effective.
Subject(s)
Bowen's Disease/complications , Carcinoma in Situ/complications , Carcinoma, Squamous Cell/complications , Genital Diseases, Female/complications , Skin Neoplasms/complications , Uterine Cervical Neoplasms/complications , Bowen's Disease/pathology , Bowen's Disease/radiotherapy , Female , Genital Diseases, Female/pathology , Genital Diseases, Female/radiotherapy , Humans , Laser Therapy , Middle Aged , Skin Neoplasms/pathology , Skin Neoplasms/radiotherapyABSTRACT
Sensitivity of 25 strains of Pityrosporum sp. to four commercial shampoos was tested using a gel diffusion method and determination of minimum inhibitory concentrations (MICs). All the shampoos when undiluted gave inhibition zones in the gel diffusion test with 13 of the 15 strains tested. Two strains were resistant to 'Polytar'. 'Polytar' was fungistatic, 'Selsun' 'Cetavlon P.C.' and 'Genisol' were fungicidal. MIC results showed the yeast to be most sensitive to 'Cetavlon' and 'Selsun'.
Subject(s)
Hair Preparations/pharmacology , Malassezia/drug effects , Immunodiffusion , Microbial Sensitivity TestsABSTRACT
A 15-year-old schoolgirl presented with a generalised progressive skin rash of six months' duration, which had been previously diagnosed as psoriasis. The facial skin lesions were particularly prominent and nodular in form. Serological tests confirmed the diagnosis of secondary syphilis, which responded to treatment.
Subject(s)
Facial Dermatoses/diagnosis , Psoriasis/diagnosis , Syphilis, Cutaneous/diagnosis , Adolescent , Diagnosis, Differential , Female , Humans , Syphilis SerodiagnosisABSTRACT
Relationships of North American damselflies of the genus Ischnura (Odonata: Zygoptera: Coenagrionidae) were investigated using a total of 1205 bp from portions of three mitochondrial genes: cytochrome b, cytochrome oxidase II, and 12S ribosomal DNA. Parsimony and neighbor joining analyses reveal a monophyletic group consisting of I. damula, I. demorsa, I. perparva, I. posita posita, I. posita atezca, I. verticalis, and probably I. denticollis, likely reflecting a recent radiation in North America. Ischnura kellicotti, I. barberi, I. prognata, I. hastata, I. ramburii, and I. capreola appear to represent much earlier divergences in the group. Many previous hypotheses of relationships among North American species of Ischnura are not supported by the molecular-based analyses. However, there is agreement in many respects between the results of the molecular phylogenetic analyses and the morphologically based conclusions of Kennedy (1919, "The Phylogeny of the Zygoptera," Ph.D. Dissertation, Cornell University, Ithaca). Although results of single-gene phylogenetic analyses often differ, there are very few cases in which there is strong support for conflicting relationships using different partitions of the data. Combined analysis of all three genes yields trees with stronger support overall than the single-gene analyses, and the combined data trees that result from diverse data treatments are congruent with one another in most respects.
Subject(s)
DNA, Mitochondrial/genetics , Insecta/genetics , Mitochondria/genetics , Phylogeny , Animals , Cytochrome b Group/genetics , DNA, Mitochondrial/chemistry , Electron Transport Complex IV/genetics , Genetic Variation , Insecta/classification , Molecular Sequence Data , RNA, Ribosomal/genetics , Species Specificity , Statistics as TopicABSTRACT
A study of 157 psoriatic patients showed that 48.4% were HL-A 17 positive (control 6.0%). The relative risk of psoriasis in HL-A 17 positive individuals (14.7) was significantly higher than that reported from other centes, whilst that for HL-A 13 was lower. HL-A 17 was commoner in femal patients and associated with an earlier age of onset of psoriasis than when HL-A 17 was absent. The earlier age of onset in females is largely due to the higher frequency of HL-A 17. Family studies show that often the ingeritance of HL-A 17 is a necessary condition for psoriasis to appear and this probably applies in some instances to HL-A 13. It is likely that there is interaction between HL-A 17 and HL-A 13 and other genes predisposing to psoriasis. In some families there appears to be no association between psoriasis and the HL-A system. The general significance of these findings is discussed.