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Bioorg Med Chem Lett
; 20(17): 5329-33, 2010 Sep 01.
Article
in English
| MEDLINE
| ID: mdl-20656487
ABSTRACT
A novel series of 2-aminobenzimidazole inhibitors of BACE1 has been discovered using fragment-based drug discovery (FBDD) techniques. The rapid optimization of these inhibitors using structure-guided medicinal chemistry is discussed.