Search details
1.
The Trypanosoma cruzi protease cruzain mediates immune evasion.
PLoS Pathog
; 7(9): e1002139, 2011 Sep.
Article
in English
| MEDLINE | ID: mdl-21909255
2.
Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.
Beilstein J Org Chem
; 9: 15-25, 2013.
Article
in English
| MEDLINE | ID: mdl-23400640
3.
Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.
Antimicrob Agents Chemother
; 54(8): 3326-34, 2010 Aug.
Article
in English
| MEDLINE | ID: mdl-20547819
4.
A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.
Antimicrob Agents Chemother
; 54(6): 2480-8, 2010 Jun.
Article
in English
| MEDLINE | ID: mdl-20385875
5.
Identification of a new class of nonpeptidic inhibitors of cruzain.
J Am Chem Soc
; 130(20): 6404-10, 2008 May 21.
Article
in English
| MEDLINE | ID: mdl-18435536
6.
Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes.
Bioorg Med Chem Lett
; 18(2): 624-8, 2008 Jan 15.
Article
in English
| MEDLINE | ID: mdl-18055204
7.
Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.
J Med Chem
; 45(13): 2695-707, 2002 Jun 20.
Article
in English
| MEDLINE | ID: mdl-12061873
8.
In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi.
PLoS Negl Trop Dis
; 4(9)2010 Sep 14.
Article
in English
| MEDLINE | ID: mdl-20856868
9.
Nonpeptidic tetrafluorophenoxymethyl ketone cruzain inhibitors as promising new leads for Chagas disease chemotherapy.
J Med Chem
; 53(4): 1763-73, 2010 Feb 25.
Article
in English
| MEDLINE | ID: mdl-20088534
10.
Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
J Med Chem
; 53(1): 52-60, 2010 Jan 14.
Article
in English
| MEDLINE | ID: mdl-19908842
11.
Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.
PLoS Negl Trop Dis
; 3(2): e372, 2009.
Article
in English
| MEDLINE | ID: mdl-19190730
12.
Drugs targeting parasite lysosomes.
Curr Pharm Des
; 14(9): 889-900, 2008.
Article
in English
| MEDLINE | ID: mdl-18473838
13.
Metal compounds for the treatment of parasitic diseases.
J Inorg Biochem
; 102(10): 1839-45, 2008 Oct.
Article
in English
| MEDLINE | ID: mdl-18684510
14.
A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection.
Antimicrob Agents Chemother
; 51(11): 3932-9, 2007 Nov.
Article
in English
| MEDLINE | ID: mdl-17698625
15.
Bis-acridines as lead antiparasitic agents: structure-activity analysis of a discrete compound library in vitro.
Antimicrob Agents Chemother
; 51(6): 2164-72, 2007 Jun.
Article
in English
| MEDLINE | ID: mdl-17371810
16.
Efecto antiparasitario de inhibidores de cistein proteasas in vitro e in vivo en la enfermedad de Chagas experimental / Trypanocidal effect of cysteine protease inhibitors in vitro and in vivo in experimental Chagas disease
Medicina (B.Aires)
; 59(supl.2): 171-5, 1999. ilus, tab
Article
in Spanish
| LILACS | ID: lil-242252
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